TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.

Autor: Mattos BR; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil., Bonacio GF; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil., Vitorino TR; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil., Garcia VT; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil., Amaral JH; Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, USP, Brazil., Dellalibera-Joviliano R; Faculty of Medicine, University of Ribeirao Preto, UNAERP and State University of Minas Gerais, UEMG, Brazil., Franca SC; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil., Tanus-Santos JE; Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, USP, Brazil., Rizzi E; Unit of Biotechnology, University of Ribeirao Preto, UNAERP, Brazil. Electronic address: ersanchez@unaerp.br.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114121. Date of Electronic Publication: 2020 Jun 25.