Výsledky vyhledávání - "Vitor H. Sousa"

The Requirement of Nkx2-1 in the Temporal Specification of Cortical Interneuron Subtypes

Autor: Gordon Fishell, Vitor H. Sousa, Marc V. Fuccillo, Simon J. B. Butt, Shioko Kimura, Jens Hjerling-Leffler, Goichi Miyoshi

Publikováno v: Neuron. 59(5):722-732

SummaryPrevious work has demonstrated that the character of mouse cortical interneuron subtypes can be directly related to their embryonic temporal and spatial origins. The relationship between embryonic origin and the character of mature interneuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecba2e610c85adf6ec1a429557b3fdcb

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Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

Autor: Albert E. Chudley, Gudrun Nürnberg, Juliana Helou, Friedhelm Hildebrandt, Massimo Attanasio, Anna Corina Treier, Peter Nürnberg, N. Henriette Uhlenhaut, John F. O'Toole, John A. Sayer, Katrin Anlag, Christian Becker, Mathias Treier, Vitor H. Sousa, Dominik Seelow, Edgar A. Otto, Claudia Klugmann

Publikováno v: Nature Genetics. 39:1018-1024

Nephronophthisis (NPHP), an autosomal recessive kidney disease, is the most frequent genetic cause of end-stage renal failure in the first three decades of life. Positional cloning of the six known NPHP genes has linked its pathogenesis to primary ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad1776542a8357543f82c9c30161562
https://doi.org/10.1038/ng2072

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A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations

Autor: Vitor H. Sousa, Pavel Osten, Jack Waters, Naoki Takada, Adam Kepecs, Hyun Jae Pi, Gord Fishell

Publikováno v: Nature Communications

The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes—parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fb8a2780e32a01b40be30199f62b1e
https://doi.org/10.1038/ncomms6333

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Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala

Autor: Sohyun Ahn, Vitor H. Sousa, Gord Fishell, Jean-Marie Mangin, Kevin Mansfield, Robert Machold, Joshua G. Corbin, Rosalind S. E. Carney, Lindsay N. Hayes, Vittorio Gallo

Publikováno v: Neural Development, Vol 5, Iss 1, p 14 (2010)
Neural Development

Background The mammalian amygdala is composed of two primary functional subdivisions, classified according to whether the major output projection of each nucleus is excitatory or inhibitory. The posterior dorsal and ventral subdivisions of the medial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6a58d4df05f2e172774da50a36f91d
http://www.neuraldevelopment.com/content/5/1/14

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Sonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain

Autor: Gord Fishell, Vitor H. Sousa

Publikováno v: Current opinion in geneticsdevelopment. 20(4)

Morphogens act during development to provide graded spatial information that controls patterning and cell lineage specification in the nervous system. The role of morphogen signaling in instructing the expression of downstream effector transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62db86bef9b61541c39f09d83d49f2f8
https://pubmed.ncbi.nlm.nih.gov/20466536

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Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons

Autor: Jens Hjerling-Leffler, Vitor H. Sousa, Theofanis Karayannis, Simon J. B. Butt, James Battiste, Jane E. Johnson, Gord Fishell, Robert Machold, Goichi Miyoshi

By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE). Interestingl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79933dcd8a48e847b0a847d80c173296
https://europepmc.org/articles/PMC2826846/

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Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells

Autor: Chris J. McBain, Vitor H. Sousa, Ludovic Tricoire, Michael I. Daw, Gord Fishell, Kenneth A. Pelkey, Brian W Jeffries, Goichi Miyoshi, Bruno Cauli

Publikováno v: Tricoire, L, Pelkey, K A, Daw, M I, Sousa, V H, Miyoshi, G, Jeffries, B, Cauli, B, Fishell, G & McBain, C J 2010, ' Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells ', The Journal of Neuroscience, vol. 30, no. 6, pp. 2165-2176 . https://doi.org/10.1523/JNEUROSCI.5123-09.2010
Journal of Neuroscience
Journal of Neuroscience, 2010, 30 (6), pp.2165-76. ⟨10.1523/JNEUROSCI.5123-09.2010⟩
Journal of Neuroscience, Society for Neuroscience, 2010, 30 (6), pp.2165-76. ⟨10.1523/JNEUROSCI.5123-09.2010⟩

GABAergic interneurons critically regulate cortical computation through exquisite spatiotemporal control over excitatory networks. Precision of this inhibitory control requires a remarkable diversity within interneuron populations that is largely spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5b38691ce8775b40997f3929c18b32
https://hdl.handle.net/20.500.11820/5377427a-a44a-4ba4-a81c-975e4e8ba00e

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Emx1-Lineage Progenitors Differentially Contribute to Neural Diversity in the Striatum and Amygdala

Autor: Molly M. Huntsman, Joshua G. Corbin, Rosalind S. E. Carney, Goichi Miyoshi, Vitor H. Sousa, Tsutomu Hirata, Laura A. Cocas, Kevin R. Jones, Gord Fishell

In the developing mammalian basal telencephalon, neural progenitors from the subpallium generate the majority of inhibitory medium spiny neurons (MSNs) in the striatum, while both pallial- and subpallial-derived progenitors contribute to excitatory a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11685affafd6e3b7344368c3cfd29caa
https://europepmc.org/articles/PMC3679174/

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Characterization of Nkx6-2-derived neocortical interneuron lineages

Autor: Gord Fishell, Jens Hjerling-Leffler, Theofanis Karayannis, Goichi Miyoshi, Vitor H. Sousa

Publikováno v: Cerebral Cortex (New York, NY)

Ventral telencephalic progenitors expressing the homeodomain transcription factor Nkx6-2 have been shown to give rise to a multitude of cortical interneuron subtypes usually associated with origin in either the medial ganglionic eminence or the cauda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bb489168e165fd7f86e0a805fa13a8
https://pubmed.ncbi.nlm.nih.gov/19363146

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