Interplay Between EGFR and the Platelet-Activating Factor/PAF Receptor Signaling Axis Mediates Aggressive Behavior of Cervical Cancer

Autor: Juliana L. Souza, Karina Martins-Cardoso, Isabella S. Guimarães, Andréia C. de Melo, Angela H. Lopes, Robson Q. Monteiro, Vitor H. Almeida

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase widely expressed in cervical tumors, being correlated with adverse clinical outcomes. EGFR may be activated by a diversity of mechanisms, including transactivation by G-protein cou

Externí odkaz: https://doaj.org/article/9d1afa614c9e44bc82930f3dbfc63e8a

Targeted cancer therapy: The future of drug combinations

Autor: Débora D. Meira, Matheus C. Casotti, Raquel F.R. Braga, Luiz C.G.S. Filho, Alessandra P. Guimarães, Camilly V. Campanharo, Daniel A. Duque, Débora G. Barbosa, Lorena M. Lopes, Victor N.G. Kohls, Lyvia N.R. Alves, Fernanda M. Garcia, Fernando L.H. Vieira, Vitor H. Almeida, Eldamaria V.W. Santos, Raquel S. Reis, Iúri D. Louro

Publikováno v: Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies ISBN: 9780128215845

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::356c6a02407bd50617c5b68fe35c2c99
https://doi.org/10.1016/b978-0-12-821584-5.00032-8

Epidermal growth factor receptor regulates fibrinolytic pathway elements in cervical cancer: functional and prognostic implications

Autor: A.C. de Melo, Fausto G. Gomes, Vitor H. Almeida, Robson Q. Monteiro, Karina Martins-Cardoso, Araci M. R. Rondon, M.M.D.C. Martins-Dinis, Tatiana Martins Tilli

Publikováno v: Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Volume: 54, Issue: 6, Article number: e10754, Published: 19 APR 2021
Brazilian Journal of Medical and Biological Research v.54 n.6 2021
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

Epidermal growth factor receptor (EGFR) signaling and components of the fibrinolytic system, including urokinase-type plasminogen activator (uPA) and thrombomodulin (TM), have been implicated in tumor progression. In the present study, we employed cB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cce6c02dc6b237133bdf82d1fc16654
https://doi.org/10.1590/1414-431x202010754

Neutrophil Extracellular Traps (NETs) Promote Pro-Metastatic Phenotype in Human Breast Cancer Cells through Epithelial–Mesenchymal Transition

Autor: Sandra König, Vitor H. Almeida, Kayo Moreira Bagri, Claudia Mermelstein, Maria Isabel D. Rossi, Robson Q. Monteiro, Karina Martins-Cardoso

Publikováno v: Cancers
Volume 12
Issue 6
Cancers, Vol 12, Iss 1542, p 1542 (2020)

Neutrophil extracellular traps (NETs) have been associated with several steps of tumor progression, including primary growth and metastasis. One of the key features for the acquisition of the metastatic ability is the epithelial&ndash
mesenchyma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9eb95578469b22e5413c3a3f81fe44

Crosstalk between BCR-ABL and protease-activated receptor 1 (PAR1) suggests a novel target in chronic myeloid leukemia

Autor: Aline Fernanda Ferreira, Vitor H. Almeida, Robson Q. Monteiro, Fausto G. Gomes, Fabíola Attié de Castro, Camilla de S. Borges, Maira da Costa Cacemiro, Natalia de Souza Nunes, Lorena Lobo de Figueiredo-Pontes, Maria Gabriela Berzoti-Coelho, Belinda Pinto Simões

Publikováno v: Experimental Hematology. 66:50-62

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome, which generates the oncogene BCR-ABL1. Protease-activated receptor 1 (PAR1) is involved in tumor progression and angiogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf16d35499fd2b518c5bbcf1068d7a3
https://doi.org/10.1016/j.exphem.2018.07.008