Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.

Autor: Gabriel Silva, Mozart Marins, Nadda Chaichanasak, Yongdae Yoon, Ana Lúcia Fachin, Vitor Caressato Pinhanelli, Luis Octávio Regasini, Mariana Bastos Dos Santos, Gabriela Miranda Ayusso, Beatriz de Carvalho Marques, Wells W Wu, Je-Nie Phue, Rong-Fong Shen, Seung Joon Baek

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0202263 (2018)

Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, t

Externí odkaz: https://doaj.org/article/c4a2f866cc5149068acd7afa844eeab7

The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1

Autor: Felipe Teixeira Lima, Viviane Seba, Gabriel Silva, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Vitor Caressato Pinhanelli, Seung J. Baek, Ana Lúcia Fachin, Luis Octavio Regasini, Mozart Marins

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 1909 (2018)

Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent in human osteosarcoma cell

Externí odkaz: https://doaj.org/article/4d91d6f9246c468ca889ea0ea6025573

DNA methylation screening after roux-en Y gastric bypass reveals the epigenetic signature stems from genes related to the surgery per se

Autor: Angel Diaz-Lagares, Carolina Ferreira Nicoletti, F. F. Casanueva, M. A. S. Pinhel, Carla Barbosa Nonino, B. A. P. de Oliveira, Ana B. Crujeiras, A. Jácome, Vitor Caressato Pinhanelli

Publikováno v: BMC Medical Genomics
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)

Background/objectives Obesity has been associated with gene methylation regulation. Recent studies have shown that epigenetic signature plays a role in metabolic homeostasis after Roux-en Y gastric bypass (RYGB). To conduct a genome-wide epigenetic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5653b72ac70e48c7878f95c34c8bc8b0
http://europepmc.org/articles/PMC6537208

Green tea supplementation improves oxidative stress biomarkers and modulates IL-6 circulating levels in obese women

Autor: Fabiani Gai Frantz, Leticia Santana Wolf, Heitor Bernardes Pereira Delfino, Julio Sérgio Marchini, Cristiana Cortes-Oliveira, Marcela Augusta de Souza Pinhel, Carla Barbosa Nonino, Vitor Caressato Pinhanelli, Bruno Affonso Parenti de Oliveira, Carolina Ferreira Nicoletti, Driele Cristina Gomes Quinhoneiro, Natália Yumi Noronha

Publikováno v: Nutrición Hospitalaria v.36 n.3 2019
SciELO España. Revistas Científicas Españolas de Ciencias de la Salud
instname
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There is a lot of evidence that some polyphenols, such as green tea, have a positive impact on the OS state and consecutively, on inflammation. Objectives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be520f4c4f9eee85c3ee90ca5701847
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112019000300013

The curcumin analog CH-5 exerts anticancer effects in human osteosarcoma cells via modulation of transcription factors p53/Sp1

Autor: Mozart Marins, Ana Lúcia Fachin, Gabriel da Silva, Viviane Seba, Vitor Caressato Pinhanelli, Seung Joon Baek, Carlos Roberto Polaquini, Luis Octávio Regasini, Felipe Teixeira Lima, Guilherme Silva Torrezan

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
International Journal of Molecular Sciences
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1909 (2018)

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f285fc9f8634ffadc540936c84a01466