Periodontal ageing and its management via pharmacological glucose modulation

Autor: Vitor C. M. Neves, Viktor Savchenko, James Daly, Paul Sharpe

Publikováno v: Frontiers in Dental Medicine, Vol 5 (2024)

Periodontal disease (PD), a widespread non-communicable disease, affects over 90% of the global population with no known cure. Current management strategies focus on the stabilisation of disease progression, which is successfully achieved to a limite

Externí odkaz: https://doaj.org/article/72e991afab3043caa84fb15a66737068

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Autor: Jan Krivanek, Ruslan A. Soldatov, Maria Eleni Kastriti, Tatiana Chontorotzea, Anna Nele Herdina, Julian Petersen, Bara Szarowska, Marie Landova, Veronika Kovar Matejova, Lydie Izakovicova Holla, Ulrike Kuchler, Ivana Vidovic Zdrilic, Anushree Vijaykumar, Anamaria Balic, Pauline Marangoni, Ophir D. Klein, Vitor C. M. Neves, Val Yianni, Paul T. Sharpe, Tibor Harkany, Brian D. Metscher, Marc Bajénoff, Mina Mina, Kaj Fried, Peter V. Kharchenko, Igor Adameyko

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Unlike human teeth, mouse incisors grow throughout life, based on stem and progenitor cell activity. Here the authors generate single cell RNA-seq comparative maps of continuously-growing mouse incisor, non-growing mouse molar and human teeth, combin

Externí odkaz: https://doaj.org/article/6c8df9e45ced47ac834d40d04694da4c

Beyond oral hygiene, are capacity-altering, biologically based interventions within the moral domain of dentistry?

Autor: Julian Savulescu, Jonathan Pugh, Vitor C. M. Neves

Oral diseases such as dental caries (DC) and periodontitis are widely prevalent, and existing approaches to managing these conditions have only a limited effect. Accordingly, there is growing interest in the development of novel biological interventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e15815ec6db58f5ecf851a47c5c0ce
https://ora.ox.ac.uk/objects/uuid:34bc6111-ca10-42f5-a138-6636964f8e9e

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Autor: Anamaria Balic, Kaj Fried, Anna Nele Herdina, Ruslan A. Soldatov, Maria Eleni Kastriti, Lydie Izakovičová Hollá, Pauline Marangoni, Marc Bajénoff, Paul T. Sharpe, Brian D. Metscher, Ivana Vidovic Zdrilic, Vitor C. M. Neves, Veronika Kovar Matejova, Jan Krivanek, Julian Petersen, Tatiana Chontorotzea, Bara Szarowska, Tibor Harkany, Val Yianni, Marie Landova, Anushree Vijaykumar, Ophir D. Klein, Ulrike Kuchler, Peter V. Kharchenko, Igor Adameyko, Mina Mina

Publikováno v: Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-18512-7⟩
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-18512-7⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a6154d3e9ebe516aa8a1488084fc9f
https://escholarship.org/uc/item/1pg0d005

Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage

Autor: Dhivya Chandrasekaran, Vitor C. M. Neves, Paul T. Sharpe, Rebecca Babb

Publikováno v: Babb, R, Chandrasekaran, D, Carvalho Moreno Neves, V & Sharpe, P T 2017, ' Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage ', Scientific Reports, vol. 7, no. 1, 3102 . https://doi.org/10.1038/s41598-017-03145-6
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports

In non-growing teeth, such as mouse and human molars, primary odontoblasts are long-lived post-mitotic cells that secrete dentine throughout the life of the tooth. New odontoblast-like cells are only produced in response to a damage or trauma. Little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922569cf6c0b8f3ff4a0b70cdb21e299
https://kclpure.kcl.ac.uk/en/publications/a570048c-f257-4ddb-92aa-5a52e9fea7e9