REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.

Autor: Fava M; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Stahl S; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Pani L; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., De Martin S; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Pappagallo M; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Guidetti C; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Alimonti A; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Bettini E; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Mangano RM; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Wessel T; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., de Somer M; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Caron J; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Vitolo OV; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., DiGuglielmo GR; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Gilbert A; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Mehta H; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Kearney M; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Mattarei A; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Gentilucci M; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Folli F; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Traversa S; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Inturrisi CE; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli)., Manfredi PL; Department of Psychiatry, Massachusetts General Hospital, Boston (Fava, Vitolo); Neuroscience Education Institute, University of California, San Diego (Stahl); Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami (Pani); Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy (Martin, Mattarei); Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, N.Y. (Pappagallo); University of Genoa, Genoa, Italy (Guidetti); Catholic University of the Sacred Heart, Rome (Guidetti); Department of Neuroscience, Child and Adolescent Psychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome (Guidetti); Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland (Alimonti); Institute of Oncology Research, Southern Switzerland, Bellinzona (Alimonti); Università della Svizzera Italiana, Bellinzona (Alimonti); Veneto Institute of Molecular Medicine, Padua, Italy (Alimonti); Department of Medicine, Zurich University, Zurich (Alimonti); University of Padua, Padua, Italy (Alimonti); In Vitro Pharmacology Department, Aptuit an Evotec Company, Verona, Italy (Bettini); Drexel University College of Medicine, Philadelphia (Mangano); Relmada Therapeutics, New York (Pappagallo, Wessel, de Somer, Caron, DiGuglielmo, Traversa, Inturrisi, Manfredi); Department of Cardiology, Syneos Health, Morrisville, N.C. (Gilbert, Mehta, Kearney); Department of Medicine, Albert Einstein College of Medicine, Bronx, N.Y. (Gentilucci); and Department of Health Science, University of Milan, Milan, Italy (Folli).

Publikováno v: The American journal of psychiatry [Am J Psychiatry] 2022 Feb; Vol. 179 (2), pp. 122-131. Date of Electronic Publication: 2021 Dec 22.

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects.

Autor: Fogaça MV; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA., Fukumoto K; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA., Franklin T; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA., Liu RJ; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA., Duman CH; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA., Vitolo OV; Relmada Therapeutics Inc., 880 Third Ave, 12th floor, New York, NY, 10022, USA., Duman RS; Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT, 06520, USA. ronald.duman@yale.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2019 Dec; Vol. 44 (13), pp. 2230-2238. Date of Electronic Publication: 2019 Aug 27.

Reply to "Letter to the Editor regarding 'Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone'".

Autor: Levinstein MR; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., De Oliveira PA; Integrative Neurobiology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Casajuana-Martin N; Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, 08193, Barcelona, Spain., Quiroz C; Integrative Neurobiology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Budinich RC; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Rais R; Johns Hopkins Drug Discovery, Neurology and Pharmacology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Rea W; Integrative Neurobiology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Ventriglia EN; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA., Llopart N; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institut de Biomedicina de la Universitat de Barcelona, 08028, Barcelona, Spain., Casadó-Anguera V; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institut de Biomedicina de la Universitat de Barcelona, 08028, Barcelona, Spain., Moreno E; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institut de Biomedicina de la Universitat de Barcelona, 08028, Barcelona, Spain., Walther D; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Glatfelter GC; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Weinshenker D; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Zarate CA Jr; Section on the Neurobiology and Treatment of Mood Disorders, National Institute of Mental Health Intramural Research Program, Bethesda, MD, 20892, USA., Casadó V; Laboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institut de Biomedicina de la Universitat de Barcelona, 08028, Barcelona, Spain., Baumann MH; Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA., Pardo L; Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Universitat Autònoma Barcelona, Bellaterra, 08193, Barcelona, Spain., Ferré S; Integrative Neurobiology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA. SFerre@intra.nida.nih.gov., Michaelides M; Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA. mike.michaelides@nih.gov.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. mike.michaelides@nih.gov.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.

Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF.

Autor: Lu MN; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China.; Science and Technology Achievement Incubation Center, Kunming Medical University, Kunming, 650500, Yunnan, China., Wang D; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Ye CJ; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Yan GJ; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Song JF; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, Yunnan, China., Shi XY; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Li SS; Experimental Teaching Center, Basic Medical College, Kunming Medical University, Kunming, 650500, Yunnan, China., Liu LN; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Zhang HX; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Dong XH; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China., Hu T; Department of Laboratory Medicine, The Third People's Hospital of Yunnan Province, Kunming, 650000, Yunnan, China., Wang XY; Department of Neurosurgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China., Xiyang YB; Institute of Neuroscience, Kunming Medical University, Kunming, 650500, Yunnan, China. xiyangyanbin@kmmu.edu.cn.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2024 Jul 05. Date of Electronic Publication: 2024 Jul 05.

Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage.

Autor: Zhang, Jie^1,2 (AUTHOR), Xue, Mingxing^3,4 (AUTHOR), Huang, Jiefang^3,4 (AUTHOR), He, Shan³ (AUTHOR), Zhu, Lingqiao³ (AUTHOR), Zhao, Xiaonan³ (AUTHOR), Wang, Bei⁴ (AUTHOR), Jiang, Tingwang¹ (AUTHOR), Zhang, Yanyun^1,4 (AUTHOR) yyzhang@sibs.ac.cn, Miao, Changhong² (AUTHOR) miaochangh@163.com, Zhou, Guoqiang^1,5 (AUTHOR) chowgq0568@163.com

Publikováno v: Journal of Translational Medicine. 5/20/2024, Vol. 22 Issue 1, p1-20. 20p.