Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vito R T, Zanotelli"'
Autor:
H. Raza Ali, Zsuzsanna Varga, Savas D. Soysal, Walter P. Weber, Simone Muenst, Bernd Bodenmiller, Robert Mechera, Jana R. Fischer, Vito R T Zanotelli, Hartland W. Jackson, Holger Moch
Publikováno v:
Nature. 578:615-620
Single-cell analyses have revealed extensive heterogeneity between and within human tumours1–4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is the foundation of m
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9 (1)
Scientific Reports
Scientific Reports, 9 (1)
Scientific Reports
Phagocytosis is a process in which target cells or particles are engulfed and taken up by other cells, typically professional phagocytes; this process is crucial in many physiological processes and disease states. The detection of targets for phagocy
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
Autor:
H Raza, Ali, Hartland W, Jackson, Vito R T, Zanotelli, Esther, Danenberg, Jana R, Fischer, Helen, Bardwell, Elena, Provenzano, Oscar M, Rueda, Suet-Feung, Chin, Samuel, Aparicio, Carlos, Caldas, X, Zhuang
Publikováno v:
Nature cancer. 1(2)
Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these relationships, we used imaging mass cytometry to quantify the expression of 37 proteins with subcellular spatial resolution i
Autor:
Bernd Bodenmiller, Denis Schapiro, Nadine Dobberstein, Vito R T Zanotelli, Marco Tognetti, James D Wade, Xiao-Kang Lun
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the proper
Autor:
Attila Gábor, Bernd Bodenmiller, Julio Saez-Rodriguez, Xiao-Kang Lun, Christian von Mering, Damian Szklarczyk, Vito R T Zanotelli, Nadine Dobberstein
Publikováno v:
Molecular Cell, 74 (5)
Molecular Cell
Molecular cell 74(5), 1086-1102.e5 (2019). doi:10.1016/j.molcel.2019.04.021
Molecular Cell
Molecular cell 74(5), 1086-1102.e5 (2019). doi:10.1016/j.molcel.2019.04.021
Summary Kinase and phosphatase overexpression drives tumorigenesis and drug resistance. We previously developed a mass-cytometry-based single-cell proteomics approach that enables quantitative assessment of overexpression effects on cell signaling. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9830df187cade67403042e215a49e2cd
https://hdl.handle.net/20.500.11850/346503
https://hdl.handle.net/20.500.11850/346503
Autor:
Fabrizio Thorel, Bernd Bodenmiller, Mark A. Atkinson, Harry S. Nick, Clive Wasserfall, Vito R T Zanotelli, Denis Schapiro, Nicolas Damond, Stefanie Engler, Irina Kusmartseva, Pedro Luis Herrera
Publikováno v:
Cell Metabolism, Vol. 29, No 3 (2019) pp. 755-768.e5
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β cells. A comprehensive picture of the changes during T1D development is lacking due to limited sample availability, inability to sample longitudinally, and the pauc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905b1fddf449897c954f1654148ed992
https://europepmc.org/articles/PMC6821395/
https://europepmc.org/articles/PMC6821395/
Autor:
Damian Szklarczyk, Bernd Bodenmiller, Vito R T Zanotelli, von Mering C, Attila Gábor, Julio Saez-Rodriguez, Xiao-Kang Lun, Nadine Dobberstein
Kinase and phosphatase overexpression drives tumorigenesis and drug resistance in many cancer types. Signaling networks reprogrammed by protein overexpression remain largely uncharacterized, hindering discovery of paths to therapeutic intervention. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a9eb2042507f16e0ee0e9e9cb0a0ea
https://doi.org/10.1101/314716
https://doi.org/10.1101/314716
Autor:
Denis Schapiro, Xiao-Kang Lun, Daniel Schulz, Bernd Bodenmiller, Stefanie Engler, Jana R. Fischer, Vito R T Zanotelli, Hartland W. Jackson
Publikováno v:
Cell Systems, 6 (1)
Cell Systems
Cell Systems
Summary To build comprehensive models of cellular states and interactions in normal and diseased tissue, genetic and proteomic information must be extracted with single-cell and spatial resolution. Here, we extended imaging mass cytometry to enable m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7874bab6859506b1677ba0c202e9bed7
https://hdl.handle.net/20.500.11850/239182
https://hdl.handle.net/20.500.11850/239182
Autor:
Tobias Ehrenberger, Saša M. Miladinović, Oliver M. Bernhardt, Olga Vitek, Lin-Yang Cheng, Tejas Gandhi, Roland Bruderer, Simon Messner, Vito R T Zanotelli, Lukas Reiter, Claudia Escher, Oliver Rinner, Yulia Butscheid
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics, 14 (5)
Molecular & Cellular Proteomics, 14 (5)
The data-independent acquisition (DIA) approach has recently been introduced as a novel mass spectrometric method that promises to combine the high content aspect of shotgun proteomics with the reproducibility and precision of selected reaction monit
Autor:
Helena L. Crowell, Bernd Bodenmiller, Mark D. Robinson, Stefanie Engler, Stéphane Chevrier, Vito R T Zanotelli
Mass cytometry enables simultaneous analysis of over 40 proteins and their modifications in single cells through use of metal-tagged antibodies. Compared to fluorescent dyes, the use of pure metal isotopes strongly reduces spectral overlap among meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73bcd9872305ef56647e6c22d9e3060
https://doi.org/10.1101/185744
https://doi.org/10.1101/185744