Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Vito G, Sasseville"'
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88cb7c9fc29a66acc799682b5292b913
https://doi.org/10.1126/scitranslmed.abb2181
https://doi.org/10.1126/scitranslmed.abb2181
Autor:
James E. Chastain, Upendra A. Argikar, Nagendra V. Chemuturi, Markus Walles, Gian Camenisch, Vito G. Sasseville, Jennifer L. Dumouchel, Mark Milton, Ganesh R. Iyer, Mithat Gunduz
Publikováno v:
Drug Metabolism and Disposition. 46:1670-1683
The eye is a complex organ with a series of anatomic barriers that provide protection from physical and chemical injury while maintaining homeostasis and function. The physiology of the eye is multifaceted, with dynamic flows and clearance mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f38ccecf4ce4c55b549ebeb317757f
https://doi.org/10.1124/dmd.118.082974
https://doi.org/10.1124/dmd.118.082974
Autor:
Ronald Newton, Steven Matsumoto, Mark Milton, Timothy K. MacLachlan, Christina L. Zuch de Zafra, Swati Gupta, Evan A Thackaberry, Iona Raymond, Elke-Astrid Atzpodien, Vito G. Sasseville, Cindy Farman, Christian Freichel
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57be7ffc5aec0060be9ba609240044cd
https://pubmed.ncbi.nlm.nih.gov/28322894
https://pubmed.ncbi.nlm.nih.gov/28322894
Publikováno v:
Veterinary Pathology. 51:281-291
The identification, application, and qualification of safety biomarkers are becoming increasingly critical to successful drug discovery and development as companies are striving to develop drugs for difficult targets and for novel disease indications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ada4235e9d19cd38eb6ac344996fe32
https://doi.org/10.1177/0300985813505117
https://doi.org/10.1177/0300985813505117
Autor:
D. L. Hutto, Prachi Sharma, Heather A. Simmons, Richard J. Montali, S. Cummings Macri, M. Owston, A. Bradley, Shiva Kumar Shanmukhappa, Saravanan Kaliyaperumal, Keith Mansfield, Lisa M. Kattenhorn, E. Gruber-Dujardin, Linda J. Lowenstine, D. Liu, Basel T. Assaf, Andrew D. Miller, Martha A. Delaney, Kerstin Mätz-Rensing, C. Tremblay, L. D. Schmidt, J. F. Reindel, Audrey Baldessari, Karen A. Terio, J. E. Markovits, Joseph L. Mankowski, J. M. Cline, Vito G. Sasseville, Cynthia L. Courtney, Carole Harbison
Publikováno v:
Veterinary Pathology. 49:1057-1069
The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b0b9f5f7f7da93f438f50f0a91b8a1
https://doi.org/10.1177/0300985812461655
https://doi.org/10.1177/0300985812461655
Autor:
Steven G. Nadler, Vito G. Sasseville, William R. Foster, Luisa Salter-Cid, David J. Shuster, Yunling Song
Publikováno v:
Veterinary Pathology. 48:885-895
Glucocorticoids (GCs), despite having many undesirable side effects, remain effective for the treatment of many inflammatory diseases and are commonly used as benchmark drugs in animal models of disease. However, the molecular mechanisms underling sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45aebf80dcf0189a5954e4b4f1b43bee
https://doi.org/10.1177/0300985810390018
https://doi.org/10.1177/0300985810390018
Autor:
Tokuma Yanai, Hiroki Sakai, Vito G. Sasseville, Daisuke Hibi, Hideto Fukushi, El-Shaymaa El-Nahass, Nagwan El-Habashi
Publikováno v:
Journal of Neurovirology. 16:242-248
Equine herpesvirus 9 (EHV-9), the newest member of the equine herpesvirus family, is a highly neurotropic herpesvirus that induces encephalitis in a variety of animals. To access transmission of EHV-9 in the nasal cavity and brain, a suckling hamster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e934260bf9e9e2298a07b399b92471a
https://doi.org/10.3109/13550284.2010.489596
https://doi.org/10.3109/13550284.2010.489596
Publikováno v:
Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24dd1311ea20dab85ffcec530b177897
https://doi.org/10.1002/9780470574898.ch9
https://doi.org/10.1002/9780470574898.ch9
Autor:
Vito G. Sasseville, Keith G. Mansfield
Publikováno v:
Journal of Immunotoxicology. 7:79-92
The increased demand for non-human primates (NHPs) in biomedical research has resulted in alternative sources of animals being used, which has allowed for importation of animals with varying background incidences of bacterial, viral, parasitic, and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7aa8fdce55fff970d4fb2a841eb0d32
https://doi.org/10.3109/15476910903213521
https://doi.org/10.3109/15476910903213521
Autor:
Vito G. Sasseville, Richard W Diters
Publikováno v:
ILAR Journal. 49:179-190
Preclinical safety studies that are required for the marketing approval of a pharmaceutical include single and repeat dose studies in rodent and nonrodent species. The use of nonhuman primates (NHPs), primarily macaques, as the nonrodent species has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba01a1f290e4296cfd22abdcdac3f19
https://doi.org/10.1093/ilar.49.2.179
https://doi.org/10.1093/ilar.49.2.179