Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Vito Calderone"'
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
Autor:
Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling, Matthew R. Groves
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Romero et al. perform NMR-based screening of 1500 fragments to identify fragments that bind at the oligomeric interface of malate dehydrogenase (MDH). Their study indicates an allosteric mechanism impacting enzymatic activity, paving the way for deve
Externí odkaz:
https://doaj.org/article/f14c722416964fa8b99c79a63335b872
Autor:
Lara Massai, Deborah Grifagni, Alessia De Santis, Andrea Geri, Francesca Cantini, Vito Calderone, Lucia Banci, Luigi Messori
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1675 (2022)
Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound Auranofin and five related gold(I) complexes as possible inhibitors of SARS-CoV-2 Main Protease (SA
Externí odkaz:
https://doaj.org/article/a3ea0616ea5a4d1899af8596752ff674
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 1009 (2022)
The importance of mitochondria in mammalian cells is widely known. Several biochemical reactions and pathways take place within mitochondria: among them, there are those involving the biogenesis of the iron–sulfur (Fe-S) clusters. The latter are ev
Externí odkaz:
https://doaj.org/article/66275a09e5ad41f9a486720d00a80761
Autor:
Caterina Ciani, Anna Pérez-Ràfols, Isabelle Bonomo, Mariachiara Micaelli, Alfonso Esposito, Chiara Zucal, Romina Belli, Vito Giuseppe D’Agostino, Irene Bianconi, Vito Calderone, Linda Cerofolini, Orietta Massidda, Michael Bernard Whalen, Marco Fragai, Alessandro Provenzani
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 922 (2022)
Acinetobacter baumannii is a Gram-negative pathogen, known to acquire resistance to antibiotics used in the clinic. The RNA-binding proteome of this bacterium is poorly characterized, in particular for what concerns the proteins containing RNA Recogn
Externí odkaz:
https://doaj.org/article/16df0fafc038477997ee00f677fd0e46
Publikováno v:
Microorganisms, Vol 10, Iss 4, p 692 (2022)
Microorganisms possess the potential to adapt to fluctuations in environmental parameters, and their evolution is driven by the continuous generation of mutations. The reversion of auxotrophic mutations has been widely studied; however, little is kno
Externí odkaz:
https://doaj.org/article/9fbaf90989e44ce68b6ee636d18480e9
Autor:
Antonio Schirò, Azzurra Carlon, Giacomo Parigi, Garib Murshudov, Vito Calderone, Enrico Ravera, Claudio Luchinat
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100019- (2020)
X-ray crystallography and NMR contain complementary information for the structural characterization of biological macromolecules. X-ray diffraction is primarily sensitive to the overall shape of the molecule, whereas NMR is mostly sensitive to the at
Externí odkaz:
https://doaj.org/article/bef19f684f934dec9308fe895453fee3
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 43 (2020)
Nature has evolved several molecular machineries to promote the formation at physiological conditions of inorganic materials, which would otherwise be formed in extreme conditions. The molecular determinants of this process have been established over
Externí odkaz:
https://doaj.org/article/0e3ced1b6a4b4d63bed51e7e924b9713
Autor:
Linda Cerofolini, Marco Fragai, Enrico Ravera, Christoph A. Diebolder, Ludovic Renault, Vito Calderone
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 370 (2019)
With the recent technological and computational advancements, structural biology has begun to tackle more and more difficult questions, including complex biochemical pathways and transient interactions among macromolecules. This has demonstrated that
Externí odkaz:
https://doaj.org/article/1d82319adf884750ad9b32aec6839c02
Autor:
Lan B T, Pham, Azzurra, Costantino, Letizia, Barbieri, Vito, Calderone, Enrico, Luchinat, Lucia, Banci
Publikováno v:
Journal of the American Chemical Society.
In-cell NMR spectroscopy is a powerful approach to study protein structure and function in the native cellular environment. It provides precious insights into the folding, maturation, interactions, and ligand binding of important pharmacological targ
Autor:
Deborah, Grifagni, Vito, Calderone, Stefano, Giuntini, Francesca, Cantini, Marco, Fragai, Lucia, Banci
Publikováno v:
Chemical communications (Cambridge, England). 57(64)
Structural data on the SARS-CoV-2 main protease in complex with a zinc-containing organic inhibitor are already present in the literature and gave hints on the presence of a zinc binding site involving the catalytically relevant cysteine and histidin