The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

Autor: Livia Misuri, Mario Cappiello, Francesco Balestri, Roberta Moschini, Vito Barracco, Umberto Mura, Antonella Del-Corso

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1152-1158 (2017)

Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. AR is subjected to intense inhibition st

Externí odkaz: https://doaj.org/article/b0c0e69a53104b82a6a2b256f9ebcb5b

Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

Autor: Francesco Balestri, Vito Barracco, Giovanni Renzone, Tiziano Tuccinardi, Christian Silvio Pomelli, Mario Cappiello, Marco Lessi, Rossella Rotondo, Fabio Bellina, Andrea Scaloni, Umberto Mura, Antonella Del Corso, Roberta Moschini

Publikováno v: Antioxidants, Vol 8, Iss 10, p 502 (2019)

The formation of the adduct between the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and glutathione, which leads to the generation of 3-glutathionyl-4-hydroxynonane (GSHNE), is one of the main routes of HNE detoxification. The aldo-keto redu

Externí odkaz: https://doaj.org/article/30180084614749bc95bed1ce6ad08b91

Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group

Autor: Francesco Balestri, Umberto Mura, Giovanni Renzone, Andrea Scaloni, Roberta Moschini, Mario Cappiello, Vito Barracco, Antonella Del-Corso

Publikováno v: Biochemical and biophysical research communications (Online) 522 (2020): 259–263. doi:10.1016/j.bbrc.2019.11.090
info:cnr-pdr/source/autori:Vito Barracco, Roberta Moschini, Giovanni Renzone, Mario Cappiello, Francesco Balestri, Andrea Scaloni, Umberto Mura, Antonella Del-Corso/titolo:Dehydrogenase%2Freductase Activity of Human Carbonyl Reductase 1 With NADP(H) Acting as a Prosthetic Group/doi:10.1016%2Fj.bbrc.2019.11.090/rivista:Biochemical and biophysical research communications (Online)/anno:2020/pagina_da:259/pagina_a:263/intervallo_pagine:259–263/volume:522

Carbonyl reductase 1 (CBR1) is an NADP-dependent enzyme that exerts a detoxifying role, which catalyses the transformation of carbonyl-containing compounds. The ability of CBR1 to act on adducts between glutathione and lipid peroxidation derived alde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f3c4446a5cc5051e5f441d4ea85410
http://hdl.handle.net/11568/1028241

Zolfino landrace (Phaseolus vulgaris L.) from Pratomagno: general and specific features of a functional food

Autor: Umberto Mura, Mario Cappiello, Livia Misuri, Rossella Rotondo, Mario Pellegrino, Andraea Andreucci, Francesco Balestri, Roberta Moschini, Antonella Del-Corso, Vito Barracco, Carlo Sorce

Publikováno v: Food & Nutrition Research, Vol 60, Iss 0, Pp 1-11 (2016)
Food & Nutrition Research; Vol 60 (2016)
Food & Nutrition Research

Background : The Zolfino bean is a variety of Phaseolus vulgaris , which is cultivated in a limited area of Tuscany, Italy, and is widely appreciated for its flavor and culinary uses. Objectives : A yellow Zolfino landrace cultivated in the Leccio-Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871a4a41b8e0c04b735d0ef5c72b122e
http://www.foodandnutritionresearch.net/index.php/fnr/article/view/31792/47792

A new role for Carbonyl Reductase 1 on 4-hydroxynonenal detoxification

Autor: Mario Cappiello, Andrea Scaloni, Umberto Mura, Vito Barracco, Giovanni Renzone, Antonella Del-Corso, Francesco Balestri, Roberta Moschini

Publikováno v: Free radical biology & medicine 124 (2018): 572–572. doi:10.1016/j.freeradbiomed.2018.05.047
info:cnr-pdr/source/autori:Moschini, Roberta; Renzone, Giovanni; Barracco, Vito; Cappiello, Mario; Scaloni, Andrea; Balestri, Francesco; Mura, Umberto; Del-Corso, Antonella/titolo:A new role for Carbonyl Reductase 1 on 4-hydroxynonenal detoxification/doi:10.1016%2Fj.freeradbiomed.2018.05.047/rivista:Free radical biology & medicine/anno:2018/pagina_da:572/pagina_a:572/intervallo_pagine:572–572/volume:124

4-Hydroxy-2-nonenal (HNE) is one of the main products of lipid autoxidation of unsaturated fatty acid (1). It is a highly reactive molecule and has received a particular attention for its biological activity and its role in different diseases (2). HN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015d2dcac95100f0177f6e24e96d1c0
https://doi.org/10.1016/j.freeradbiomed.2018.05.047