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Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression.

Autor: Zhang, Ling, Zou, Wenyu, Zhang, Shixuan, Wu, Honghua, Gao, Ying, Zhang, Junqing, Zheng, Jia

Publikováno v: Cellular & Molecular Biology Letters; 12/18/2024, Vol. 29 Issue 1, p1-20, 20p

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.

Autor: Driessen M; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address: marja.driessen@embl.de., Vitins AP; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands., Pennings JL; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Kienhuis AS; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Water Bv; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands., van der Ven LT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

Publikováno v: Toxicology letters [Toxicol Lett] 2015 Jan 22; Vol. 232 (2), pp. 403-12. Date of Electronic Publication: 2014 Nov 24.

Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

Autor: Driessen M; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands., Kienhuis AS; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Vitins AP; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands., Pennings JL; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands., Pronk TE; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Department of Toxicogenomics, Maastricht University, 6200 MD Maastricht, The Netherlands., van den Brandhof EJ; Centre for Environmental Quality, National Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720 BA Bilthoven, The Netherlands., Roodbergen M; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands., van de Water B; Division of Toxicology, Leiden/Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands., van der Ven LT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: leo.van.der.ven@rivm.nl.

Publikováno v: Toxicology letters [Toxicol Lett] 2014 Oct 01; Vol. 230 (1), pp. 48-56. Date of Electronic Publication: 2014 Jul 24.

Obesity at conception programs the opioid system in the offspring brain.

Autor: Grissom NM; 1] Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lyde R; Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Christ L; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sasson IE; Department of Obstetric and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Carlin J; 1] Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Vitins AP; Department of Obstetric and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Simmons RA; 1] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA [2] Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA [3] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Reyes TM; 1] Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA [2] Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2014 Mar; Vol. 39 (4), pp. 801-10. Date of Electronic Publication: 2013 Aug 08.