Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vithya Manoharan"'
Autor:
Susmitha Vuddagiri, Doris Hui Ying Tee, Sandra Sim, Alvin W. Hung, Gang Wang, Thomas H. Keller, Li Hong Tan, Zhiyuan Ke, Anders Poulsen, Nithya Baburajendran, Boping Liu, Vishal Pendharkar, Pearly Shuyi Ng, Jeffrey Hill, Jothi Anantharajan, Joma Joy, May Ann Lee, Zekui Perlyn Kwek, Kanda Sangthongpitag, Sifang Wang, Vithya Manoharan, Klement Foo, Chuhui Huang, Nur Huda Binte Ahmad
Publikováno v:
Bioorganicmedicinal chemistry. 49
AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its overexpression is associated with poor disease prognosis and acquired drug resistance. Utilizing a fragment-based l
Autor:
Jacek Kwiatkowski, Boping Liu, Shermaine Pang, Nur Huda Binte Ahmad, Gang Wang, Anders Poulsen, Haiyan Yang, Yong Rui Poh, Doris Hui Ying Tee, Esther Ong, Priya Retna, Nurul Dinie, Perlyn Kwek, John Liang Kuan Wee, Vithya Manoharan, Choon Bing Low, Peck Gee Seah, Vishal Pendharkar, Kanda Sangthongpitag, Joma Joy, Nithya Baburajendran, Anna Elisabet Jansson, Kassoum Nacro, Jeffrey Hill, Thomas H. Keller, Alvin W. Hung
Publikováno v:
Journal of medicinal chemistry. 63(2)
Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various cancers. Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) play a fundamental role in activation of eIF4E. Structure-activity relat
Autor:
Thomas H. Keller, Zhiyuan Ke, Vithya Manoharan, May Ann Lee, Anders Poulsen, David M. Virshup, Yun Shan Chew, Kanda Sangthongpitag, Vishal Pendharkar, Soo Yei Ho, Eldwin Sum Wai Tan, Choon Bing Low, Jenefer Alam, Li Jun Ding, Weiling Wang, Babita Madan, Shi Hua Ang, Duraiswamy Athisayamani Jeyaraj, Jeffrey Hill, Grace Lin
Publikováno v:
Journal of Medicinal Chemistry. 60:6678-6692
Porcupine is an O-acyltransferase that regulates Wnt secretion. Inhibiting porcupine may block the Wnt pathway which is often dysregulated in various cancers. Consequently porcupine inhibitors are thought to be promising oncology therapeutics. A high
Autor:
Jeffrey Hill, Joma Joy, Grace Lin, Nurul Dinie, Justina Fulwood, Sin Yin Chew, Xiaoying Koh-Stenta, Sugunavathi Sepramaniam, Xin Hui Chew, Rong Li, Melgious Jin Yan Ang, May Ann Lee, Alex Matter, Weixuan Yu, Zhiyuan Ke, Anna Ngo, Hwa Hwa Chung, Susmitha Vuddagiri, Kanda Sangthongpitag, Klement Foo, Vithya Manoharan, C. S. Brian Chia, Sravanthy Manesh, Esther H. Q. Ong, Nithya Baburajendran, Chuhui Huang, Zekui Perlyn Kwek, John Liang Kuan Wee, Yun Shan Chew, Priya Retna, Thomas H. Keller, Anders Poulsen, Si Si Liew, Choon Bing Low, Vishal Pendharkar
Publikováno v:
ACS Med Chem Lett
[Image: see text] SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of tetrahydroacridine compounds which inhibit SMYD3 through a covalent mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a957218bb54c41c184fbdaf7cb115a0
https://europepmc.org/articles/PMC6580565/
https://europepmc.org/articles/PMC6580565/
Autor:
Vithya Manoharan, Yun Xuan Wong, Esther H. Q. Ong, Kassoum Nacro, John Liang Kuan Wee, Zekui Perlyn Kwek, Sharon Xiaodai Lim, Jeffrey Hill, Yun Shan Chew, Zhi Ying Poh, S. Tiong Ong, Thomas H. Keller, Li Jun Ding, Joma Joy, Vishal Pendharkar, Samantha Guo, Kanda Sangthongpitag, Anders Poulsen, Hai Yan Yang, May Ann Lee, Boping Liu, Meng Ling Choong, Duraiswamy Athisayamani Jeyaraj, Joseph Cherian, Melvyn Ho
Publikováno v:
Journal of Medicinal Chemistry. 59:3063-3078
Clinically used BCR-ABL1 inhibitors for the treatment of chronic myeloid leukemia do not eliminate leukemic stem cells (LSC). It has been shown that MNK1 and 2 inhibitors prevent phosphorylation of eIF4E and eliminate the self-renewal capacity of LSC
Autor:
Sugunavathi Sepramaniam, Thomas H. Keller, Alex Matter, Xiaoying Koh-Stenta, May Ann Lee, Nurul Dinie, Anders Poulsen, Justina Fulwood, Weixuan Yu, Anna Ngo, Grace Lin, Sin Yin Chew, Xin Hui Chew, Joma Joy, Melgious Jin Yan Ang, Priya Retna, Kanda Sangthongpitag, Nithya Baburajendran, John Liang Kuan Wee, Klement Foo, Jeffrey Hill, Vithya Manoharan, Zekui Perlyn Kwek, Esther H. Q. Ong, Zhiyuan Ke, Rong Li, Chuhui Huang, Hwa Hwa Chung, C. S. Brian Chia, Yun Shan Chew, Susmitha Vuddagiri, Sravanthy Manesh, Vishal Pendharkar, Si Si Liew, Choon Bing Low
Publikováno v:
ACS Medicinal Chemistry Letters. 10:1240-1240
Autor:
A O Frois, Kanda Sangthongpitag, Vishal Pendharkar, Esther Hq Ong, Enrico Petretto, David M. Virshup, Nathan Harmston, Babita Madan, Jenefer Alam, I H Virshup, Thomas H. Keller, Duraiswamy Athisayamani Jeyaraj, Kakaly Ghosh, Jeffrey Hill, Zhiyuan Ke, Alex Matter, May Ann Lee, Soo Yei Ho, Vithya Manoharan
Publikováno v:
Oncogene
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72602c084261426c44771fd994ae8f4e
Autor:
Yun Shan Chew, Vithya Manoharan, Babita Madan, Zhiyuan Ke, Li Jun Ding, Anders Poulsen, Jenefer Alam, Soo Yei Ho, Wei Wen Vivien Cheong, Thomas H. Keller, Kanda Sangthongpitag, May Ann Lee, David M. Virshup, Eldwin Sum Wai Tan, Shi Hua Ang, Vishal Pendharkar, Athisayamani Jeyaraj Duraiswamy
Publikováno v:
Journal of medicinal chemistry. 58(15)
Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmito
Autor:
Thomas H. Keller, David M. Virshup, Alex Matter, Yun Shan Chew, Vishal Pendharkar, Jeffrey Hill, Babita Madan, Choon Bing Low, Vithya Manoharan, Soo Yei Ho, Wei Ling Wang, Hongqian Esther Ong, May Ann Lee, Kanda Sangthongpitag, Jeyaraj Duraiswamy Athisayamani
Publikováno v:
Cancer Research. 77:1172-1172
Porcupine (PORCN), a muti-pass integral membrane-bound-O-Acyl acyltransferase (MBOAT), resides in the in the endoplasmic reticulum (ER) and is required for biogenesis of Wnt ligands. The secreted mature Wnt ligands bind to their cognate receptors (Fr
Autor:
May Ann Lee, Zhiyuan Ke, Sifang Wang, Sharon Xiaodai Lim, Sin Tiong Ong, Vithya Manoharan, Esther H. Q. Ong, Susmitha Vuddagiri, Nacro Kassoum, Kanda Sangthongpitag, Jeffrey Hill
Publikováno v:
Cancer Research. 77:3819-3819
Elevated levels of the phosphorylated m7G cap binding protein, eukaryotic initiation factor 4E (eIF4E) are associated with neoplasia. An observed oncogenic signaling effect upon activation of Erk1/2 or p38 MAPKs in cells is the phosphorylation of eIF