Výsledky vyhledávání - "Vithiyanjali Sothilingam"

Akademický článek

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects

Autor: Regine Mühlfriedel, Naoyuki Tanimoto, Christian Schön, Vithiyanjali Sothilingam, Marina Garcia Garrido, Susanne C. Beck, Gesine Huber, Martin Biel, Mathias W. Seeliger, Stylianos Michalakis

Publikováno v: Frontiers in Neuroscience, Vol 11 (2017)

Achromatopsia type 2 (ACHM2) is a severe, inherited eye disease caused by mutations in the CNGA3 gene encoding the α subunit of the cone photoreceptor cyclic nucleotide-gated (CNG) channel. Patients suffer from strongly impaired daylight vision, pho

Externí odkaz: https://doaj.org/article/d81172a81af2418db119c2b191a8f372

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Akademický článek

Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease.

Autor: Susanne C Beck, Yuxi Feng, Vithiyanjali Sothilingam, Marina Garcia Garrido, Naoyuki Tanimoto, Niyazi Acar, Shenliang Shan, Britta Seebauer, Wolfgang Berger, Hans-Peter Hammes, Mathias W Seeliger

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178753 (2017)

Loss of Norrin signalling due to mutations in the Norrie disease pseudoglioma gene causes severe vascular defects in the retina, leading to visual impairment and ultimately blindness. While the emphasis of experimental work so far was on the developm

Externí odkaz: https://doaj.org/article/120f311049c64ceca8394ad333f61a26

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Akademický článek

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

Autor: Vithiyanjali Sothilingam, Stylianos Michalakis, Marina Garcia Garrido, Martin Biel, Naoyuki Tanimoto, Mathias W Seeliger

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147728 (2016)

Vision originates in rods and cones at the outer retina. Already at these early stages, diverse processing schemes shape and enhance image information to permit perception over a wide range of lighting conditions. In this work, we address the role of

Externí odkaz: https://doaj.org/article/37dc61ff7c1e463c97f9cb7ed30532da

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Akademický článek

Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Autor: Christine Weinl, Christine Wasylyk, Marina Garcia Garrido, Vithiyanjali Sothilingam, Susanne C Beck, Heidemarie Riehle, Christine Stritt, Michel J Roux, Mathias W Seeliger, Bohdan Wasylyk, Alfred Nordheim

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107048 (2014)

Serum Response Factor (SRF) fulfills essential roles in post-natal retinal angiogenesis and adult neovascularization. These functions have been attributed to the recruitment by SRF of the cofactors Myocardin-Related Transcription Factors MRTF-A and -

Externí odkaz: https://doaj.org/article/21e962436efc48d5a51fe85db84544b6

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Akademický článek

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

Autor: Lucie P Pellissier, Celso Henrique Alves, Peter M Quinn, Rogier M Vos, Naoyuki Tanimoto, Ditte M S Lundvig, Jacobus J Dudok, Berend Hooibrink, Fabrice Richard, Susanne C Beck, Gesine Huber, Vithiyanjali Sothilingam, Marina Garcia Garrido, André Le Bivic, Mathias W Seeliger, Jan Wijnholds

Publikováno v: PLoS Genetics, Vol 9, Iss 12, p e1003976 (2013)

Development in the central nervous system is highly dependent on the regulation of the switch from progenitor cell proliferation to differentiation, but the molecular and cellular events controlling this process remain poorly understood. Here, we rep

Externí odkaz: https://doaj.org/article/a8b7e12b19c843c0a8d80c71c4476db7

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Akademický článek

PGC-1α determines light damage susceptibility of the murine retina.

Autor: Anna Egger, Marijana Samardzija, Vithiyanjali Sothilingam, Naoyuki Tanimoto, Christina Lange, Silvia Salatino, Lei Fang, Marina Garcia-Garrido, Susanne Beck, Michal J Okoniewski, Albert Neutzner, Mathias W Seeliger, Christian Grimm, Christoph Handschin

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31272 (2012)

The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand. For example, PGC-1α and PGC-1β control organ functi

Externí odkaz: https://doaj.org/article/580a7c26d1df46de89503cf0170744fd

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Akademický článek

Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina.

Autor: Gerrit Hilgen, Antje K Huebner, Naoyuki Tanimoto, Vithiyanjali Sothilingam, Christina Seide, Marina Garcia Garrido, Karl-Friedrich Schmidt, Mathias W Seeliger, Siegrid Löwel, Reto Weiler, Christian A Hübner, Karin Dedek

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46155 (2012)

Regulation of ion and pH homeostasis is essential for normal neuronal function. The sodium-driven chloride bicarbonate exchanger NCBE (Slc4a10), a member of the SLC4 family of bicarbonate transporters, uses the transmembrane gradient of sodium to dri

Externí odkaz: https://doaj.org/article/ad4f535473474f3c861e01bdc96b4f29

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