Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Vitaxin"'
Autor:
Siti Aqlima Ahmad, Wan Norhamidah Wan Ibrahim, Ferdaus Mohamat Yusuf, Ibrahim Bakari Hassan, Syahida Ahmad
Publikováno v:
Journal of Toxicology, Vol 2020 (2020)
Background. Pathophysiological changes leading to the death of nerve cells present in the brain and spinal cord are referred to as neurodegenerative diseases. Presently, treatment of these diseases is not effective and encounters many challenges due
Autor:
Félix A. Rey, Marija Backovic, David Veesler, Zachary M. James, Mark H. Ginsberg, Andrew J. Borst, Frank DiMaio, William N. Zagotta
Publikováno v:
Structure
Structure, Elsevier (Cell Press), 2017, 25 (11), pp.1732-1739.e5. ⟨10.1016/j.str.2017.09.007⟩
Structure, 2017, 25 (11), pp.1732-1739.e5. ⟨10.1016/j.str.2017.09.007⟩
Structure, Elsevier (Cell Press), 2017, 25 (11), pp.1732-1739.e5. ⟨10.1016/j.str.2017.09.007⟩
Structure, 2017, 25 (11), pp.1732-1739.e5. ⟨10.1016/j.str.2017.09.007⟩
International audience; The LM609 antibody specifically recognizes αVβ3 integrin and inhibits angiogenesis, bone resorption, and viral infections in an arginine-glycine-aspartate-independent manner. LM609 entered phase II clinical trials for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38090c90585f95553dd457680131dd28
https://hal-pasteur.archives-ouvertes.fr/pasteur-01632900
https://hal-pasteur.archives-ouvertes.fr/pasteur-01632900
Autor:
Borst, Andrew J, James, Zachary M, Zagotta, William N, Ginsberg, Mark, Rey, Felix A, DiMaio, Frank, Backovic, Marija, Veesler, David
Publikováno v:
Structure (London, England : 1993), vol 25, iss 11
The LM609 antibody specifically recognizes αVβ3 integrin and inhibits angiogenesis, bone resorption, and viral infections in an arginine-glycine-aspartate-independent manner. LM609 entered phase II clinical trials for the treatment of several cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::8ff1b1d64cf469aa6c3c5bb889240349
https://escholarship.org/uc/item/3r2256rz
https://escholarship.org/uc/item/3r2256rz
Autor:
Karina Vera, Sandrine Faivre, Karen Kaucic, Luz Hammershaimb, Michel Marty, Eric Raymond, Catherine Delbaldo, Stéphanie Lozahic
Publikováno v:
Investigational New Drugs. 26:35-43
This study assessed the safety, immunogenicity, and pharmacokinetics of etaracizumab, a monoclonal antibody directed against the alphavbeta3 integrin, in patients with advanced malignancies. Four cohorts of four patients received escalating dose of e
Autor:
Jill D. Bashutski, Morris F. Manolson, S. Jeffrey Dixon, Stephen M. Sims, Johan N. M. Heersche, Seema Shorey, Azza Gramoun
Publikováno v:
Physiology and Pharmacology Publications
The integrin alphavbeta3 mediates cell-matrix interactions. Vitaxin(R), a humanized monoclonal antibody that blocks human and rabbit alphavbeta3 integrins, is in clinical trials for metastatic melanoma and prostate cancer. alphavbeta3 is the predomin
Publikováno v:
Cancer Research. 66:9673-9681
AbegrinTM (MEDI-522 or VitaxinTM), a humanized monoclonal antibody against human integrin αvβ3, is in clinical trials for cancer therapy. In vivo imaging using AbegrinTM-based probes is needed for better treatment monitoring and dose optimization.
Autor:
R L Wilder
Publikováno v:
Annals of the Rheumatic Diseases. 61:96ii-99
A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, migration, and bone resorption, and inflammatory an
Akademický článek
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Publikováno v:
Circulation Research. 84:1268-1276
Abstract —The vitronectin receptor (α v β 3 ) mediates several biological processes that are critical to the formation of a neointima after coronary interventions. Blockade of α v β 3 could reduce neointima formation by inhibiting smooth muscle
Autor:
Charles Saadeh, Constantine Saadeh
Publikováno v:
Journal of Asthma. 44:281-283
Asthma is a chronic inflammatory condition. An integral part of the inflammation is angiogenesis (neovascularization). This report describes a patient with rheumatoid arthritis (RA) and moderately severe asthma despite maintenance on inhaled corticos