Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Vitalyi O. Rybin"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C770-C778
Protein kinase C-δ (PKCδ) exerts important cardiac actions as a lipid-regulated kinase. There is limited evidence that PKCδ also might exert an additional kinase-independent action as a regulator of the subcellular compartmentalization of binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c452cc50c2f4abfdbbeaa15d60871ce
https://doi.org/10.1152/ajpcell.00170.2010
https://doi.org/10.1152/ajpcell.00170.2010
Publikováno v:
Journal of Muscle Research and Cell Motility. 30:67-72
Phosphorylation of cardiac troponin is a key mechanism involved in regulation of contractile function. In vitro kinase assays revealed that lysates prepared from resting cardiomyocytes contain cardiac troponin I (cTnI) and cTnT kinase activity. cTnI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fc48b1c175c569a10031b282e164c3
https://doi.org/10.1007/s10974-009-9176-y
https://doi.org/10.1007/s10974-009-9176-y
Publikováno v:
Journal of Biological Chemistry. 283:17777-17788
Protein kinase Cdelta (PKCdelta) activation is generally attributed to lipid cofactor-dependent allosteric activation mechanisms at membranes. However, recent studies indicate that PKCdelta also is dynamically regulated through tyrosine phosphorylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4509a60d6e8b7850efd7d26d8abc47
https://doi.org/10.1074/jbc.m800333200
https://doi.org/10.1074/jbc.m800333200
Autor:
Vitalyi O. Rybin, Susan F. Steinberg
Publikováno v:
Biochemical and Biophysical Research Communications. 368:408-413
Heterotrimeric G proteins are comprised of a guanine nucleotide binding Galpha subunit and the Gbetagamma dimers that link G protein-coupled receptors (GPCRs) to effectors. This study focuses on the expression and localization patterns for certain Gb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a422d01cac367ce07ed3ea0f24383f0d
https://doi.org/10.1016/j.bbrc.2008.01.100
https://doi.org/10.1016/j.bbrc.2008.01.100
Publikováno v:
Journal of Biological Chemistry. 282:23631-23638
Protein kinase Cdelta (PKCdelta) is unusual among AGC kinases in that it does not require activation loop (Thr(505)) phosphorylation for catalytic competence. Nevertheless, Thr(505) phosphorylation has been implicated as a mechanism that influences P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974d957f7316355fcf0c7e2b605daedb
https://doi.org/10.1074/jbc.m701676200
https://doi.org/10.1074/jbc.m701676200
Publikováno v:
Circulation Research. 99:1367-1375
AKT is a potent antiapoptotic kinase, but its role in the cardioprotective actions of α 1 -adrenergic receptors (ARs) remains uncertain, because α 1 -ARs typically induce little-to-no AKT activation in most cardiomyocyte models. This study identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b1e77fd959f9f6cf1298d334ba4c92
https://doi.org/10.1161/01.res.0000252830.01581.fd
https://doi.org/10.1161/01.res.0000252830.01581.fd
Autor:
Susan F. Steinberg, Vitalyi O. Rybin
Publikováno v:
American Journal of Physiology-Cell Physiology. 290:C750-C756
Antibodies that specifically recognize signaling proteins (or individual phosphorylation events at specific residues in proteins of interest) have become important tools in the study of signaling pathways. However, the recognition properties of many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697fe593fcf68570afd7aecac676bd2a
https://doi.org/10.1152/ajpcell.00395.2005
https://doi.org/10.1152/ajpcell.00395.2005
Autor:
Ivona Kozieradzki, Junko Irie-Sasaki, Susan F. Steinberg, Urs Eriksson, Michael A. Crackower, Takehiko Sasaki, Dominica Gidrewicz, Teiji Wada, Josef M. Penninger, Renu Sarao, Gavin Y. Oudit, Peter H. Backx, Vitalyi O. Rybin
Publikováno v:
Circulation. 108:2147-2152
Background— We have recently shown that genetic inactivation of phosphoinositide 3-kinase γ (PI3Kγ), the isoform linked to G-protein–coupled receptors, results in increased cardiac contractility with no effect on basal cell size. Signaling via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0012e6e20b469b978f10929afada6994
https://doi.org/10.1161/01.cir.0000091403.62293.2b
https://doi.org/10.1161/01.cir.0000091403.62293.2b
Publikováno v:
Molecular Pharmacology. 63:1338-1348
Cardiomyocyte beta2-adrenergic receptors (beta-ARs) provide a source of inotropic support and influence the evolution of heart failure. Recent studies identify distinct mechanisms for beta2-AR actions in neonatal and adult rat cardiomyocytes. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799afa7cc14a2cd2942666d937d36804
https://doi.org/10.1124/mol.63.6.1338
https://doi.org/10.1124/mol.63.6.1338
Autor:
Susan F. Steinberg, Jeffery D. Molkentin, Julian C. Braz, Abdelkarim Sabri, Vitalyi O. Rybin, Jacob Short
Publikováno v:
Journal of Biological Chemistry. 278:14555-14564
Recent studies identify conventional protein kinase C (PKC) isoform phosphorylations at conserved residues in the activation loop and C terminus as maturational events that influence enzyme activity and targeting but are not dynamically regulated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19a79f243fab234f977d5882707a09a
https://doi.org/10.1074/jbc.m212644200
https://doi.org/10.1074/jbc.m212644200