Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vitaly V. Komnatnyy"'
Autor:
Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan A Pless
Publikováno v:
eLife, Vol 6 (2017)
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in
Externí odkaz:
https://doaj.org/article/1350a5c1730a41c381d865b7cfbe34e4
Autor:
Katrine Qvortrup, Vitaly V. Komnatnyy, Kim T. Mortensen, Jonas O. Petersen, Thomas E. Nielsen, Katrine E. Christensen, Mathias T. Nielsen
Publikováno v:
Petersen, J, Christensen, P K, Nielsen, M T, Mortensen, K T, Komnatnyy, V V, Nielsen, T E & Qvortrup, K 2018, ' Oxidative Modification of Tryptophan-Containing Peptides ', A C S Combinatorial Science, vol. 20, no. 6 . https://doi.org/10.1021/acscombsci.8b00014
We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925dfdd9ec4643ada17a379324dea00f
https://orbit.dtu.dk/en/publications/c40f7ccf-07ef-43a9-83b8-938a313acb2f
https://orbit.dtu.dk/en/publications/c40f7ccf-07ef-43a9-83b8-938a313acb2f
Autor:
Kennedy M. Taveras, Sebastian Thordal Le Quement, Thomas E. Nielsen, Michael Givskov, Nitin Subhash Nandurkar, Vitaly V. Komnatnyy
Publikováno v:
European Journal of Organic Chemistry. 2015:3524-3530
We report the results of our recent investigations into the reactivity of cyclic solid-supported N-acyliminium ions. An intermolecular Mannich-type transformation of these intermediates was used to generate libraries of substituted lactams. Masked al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc936d6ea06ef2f3fb484d2579a889e5
https://doi.org/10.1002/ejoc.201500054
https://doi.org/10.1002/ejoc.201500054
Autor:
Céline Boiteux, Emelie Flood, Toby W. Allen, Stephan A. Pless, Vitaly V. Komnatnyy, Timothy Lynagh, Matthias Wulf, Janne M. Colding
Publikováno v:
Lynagh, T, Flood, E, Boiteux, C, Wulf, M, Komnatnyy, V V, Colding, J M, Allen, T W & Pless, S A 2017, ' A selectivity filter at the intracellular end of the acid-sensing ion channel pore ', eLife, vol. 6, 24630 . https://doi.org/10.7554/eLife.24630
eLife
eLife, Vol 6 (2017)
eLife
eLife, Vol 6 (2017)
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e0f95155bd2f73295c63c74f1da8cf
https://curis.ku.dk/portal/da/publications/a-selectivity-filter-at-the-intracellular-end-of-the-acidsensing-ion-channel-pore(35627d9d-feb8-4f89-ace1-d195e9eb8904).html
https://curis.ku.dk/portal/da/publications/a-selectivity-filter-at-the-intracellular-end-of-the-acidsensing-ion-channel-pore(35627d9d-feb8-4f89-ace1-d195e9eb8904).html
Publikováno v:
Lynagh, T, Komnatnyy, V V & Pless, S A 2017, ' Unique contributions of an arginine side chain to ligand recognition in a glutamate-gated chloride channel ', The Journal of Biological Chemistry, vol. 292, pp. 3940-3946 . https://doi.org/10.1074/jbc.M116.772939
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Glutamate recognition by neurotransmitter receptors often relies on arginine (Arg) residues in the binding site, leading to the assumption that charge-charge interactions underlie ligand recognition. However, assessing the precise chemical contributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079652240000e7ccea54f34d0271b62d
https://curis.ku.dk/portal/da/publications/unique-contributions-of-an-arginine-side-chain-to-ligand-recognition-in-a-glutamategated-chloride-channel(83f5a4a7-159a-4be4-a919-62e8367ec0eb).html
https://curis.ku.dk/portal/da/publications/unique-contributions-of-an-arginine-side-chain-to-ligand-recognition-in-a-glutamategated-chloride-channel(83f5a4a7-159a-4be4-a919-62e8367ec0eb).html
Publikováno v:
Organic Letters. 16:4782-4785
A photolabile hydrazine linker for the solid-phase synthesis of peptide hydrazides and hydrazine-derived heterocycles is presented. The developed protocols enable the efficient synthesis of structurally diverse peptide hydrazides derived from the sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0bff0e253fcd4faadb0068a4b089c0
https://doi.org/10.1021/ol502219s
https://doi.org/10.1021/ol502219s
Publikováno v:
Topics in Heterocyclic Chemistry ISBN: 9783319491233
Peptidomimetics offers a solution to the poor pharmacokinetic properties displayed by natural peptides, by providing pharmaceutically useful chemical structures with the ability to mimic the endogenous polyamide structure. This chapter gives an overv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c196fcf2f07b49311b35d1e459631f
https://doi.org/10.1007/7081_2015_190
https://doi.org/10.1007/7081_2015_190
Autor:
Emelie Flood, Timothy Lynagh, Vitaly V. Komnatnyy, Céline Boiteux, Toby W. Allen, Stephan A. Pless, Matthias Wulf, Janne M. Colding
Publikováno v:
Biophysical Journal. 112:476a-477a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e7f95aff6e74526775df6086effe502
https://doi.org/10.1016/j.bpj.2016.11.2581
https://doi.org/10.1016/j.bpj.2016.11.2581
Autor:
Michael Givskov, Nitin Subhash Nandurkar, Vitaly V. Komnatnyy, Robin Frauenlob, Kennedy M. Taveras, Sebastian Thordal Le Quement, Rico Petersen, Katrine Qvortrup, Thomas E. Nielsen
Publikováno v:
Tetrahedron Letters. 52:7121-7124
An efficient method for the solid-phase synthesis of hydroxamic acids is described. The method comprises the nucleophilic displacement of esters immobilized on PEGA resins with hydroxylamine/sodium hydroxide in isopropanol. The hydroxyaminolysis prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012eed2a42e003ccaaa5dc69c58177fb
https://doi.org/10.1016/j.tetlet.2011.10.103
https://doi.org/10.1016/j.tetlet.2011.10.103