Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vitaly P. Pozharov"'
Autor:
Vitaly P. Pozharov, Tamara Minko
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 194 (2023)
Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic.
Externí odkaz:
https://doaj.org/article/705e334b3c744b47893df2af48c86a41
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society
Cystic fibrosis (CF), a most deadly genetic disorder, is caused by mutations of CF transmembrane receptor (CFTR) - a chloride channel present at the surface of epithelial cells. In general, two steps have to be involved in treatment of the disease: c
Autor:
Olga B. Garbuzenko, Maha Saad, Vitaly P. Pozharov, Seema Betigeri, Tamara Minko, Viatcheslav A. Soldatenkov, Min Zhang, Alexandre A. Vetcher, David C. Reimer
Publikováno v:
Pharmaceutical Research. 26:382-394
To compare systemic intravenous and local intratracheal delivery of doxorubicin (DOX), antisense oligonucleotides (ASO) and small interfering RNA (siRNA). “Neutral” and cationic liposomes were used to deliver DOX, ASO, and siRNA. Liposomes were c
Autor:
Alexandre A. Vetcher, Refika I. Pakunlu, Jayant Khandare, Olga B. Garbuzenko, Tamara Minko, Vitaly P. Pozharov, Viatcheslav A. Soldatenkov, Maha Saad, Yang Wang
Publikováno v:
Clinical Cancer Research. 14:3607-3616
Purpose: To enhance the efficacy of cancer treatment, we propose a complex approach: simultaneous delivery to the tumor of a chemotherapeutic agent and a suppressor of hypoxia-inducible factor 1α (HIF1A). Experimental Design: The novel complex lipos
Autor:
Yang Wang, Clifford Qualls, Alfredo Gamboa, Otto Appenzeller, Vitaly P. Pozharov, Tamara Minko, Jorge L. Gamboa
Publikováno v:
Clinical Autonomic Research. 16:217-222
Autonomic function is altered by altitude in sojourners and natives. We hypothesized that these physiologic responses are modulated by changes in gene expression. We compared gene product levels in 20 natives of Cerro de Pasco (CP), (4338 m), 10 of w
Publikováno v:
Cancer Research. 64:6214-6224
The efficacy of chemotherapy of lung cancer is limited by the development of resistance in cancer cells during treatment. In most lung cancers, this resistance is associated with the overexpression of (a) multidrug resistance-associated protein (MRP)
Autor:
Luca Malcovati, Luciano Bernardi, Maurizio Bonfichi, Otto Appenzeller, Vitaly P. Pozharov, Jorge L. Gamboa, Tamara Minko
Publikováno v:
Journal of the Neurological Sciences. 207:37-41
Chronic mountain sickness (CMS), a maladaptation syndrome to chronic hypoxia, occurs in the Andes. Gene expression differences in Andeans could explain adaptation and maladaptation to hypoxia, both of which are relevant to neurology at sea level. Exp
Publikováno v:
Advanced drug delivery reviews. 65(13-14)
The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffect
Autor:
Vitaly P. Pozharov, Tamara Minko, David C. Reimer, Vera Ivanova, Kenneth R. Reuhl, Olga B. Garbuzenko
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal form of interstitial lung disease. We hypothesized that the local pulmonary delivery of prostaglandin E2 (PGE2) by liposomes can be used for the effective treatment of IPF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad8688631eaca5c0cbfaa785f4e8606
https://europepmc.org/articles/PMC3660419/
https://europepmc.org/articles/PMC3660419/
Autor:
Maha Saad, Gediminas Mainelis, Olga B. Garbuzenko, Vitaly P. Pozharov, Kenneth R. Reuhl, Tamara Minko
Development of cancer cell resistance, low accumulation of therapeutic drug in the lungs, and severe adverse treatment side effects represent main obstacles to efficient chemotherapy of lung cancer. To overcome these difficulties, we propose inhalati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b9a99432a81e85425a84069d38ad50
https://europepmc.org/articles/PMC2890783/
https://europepmc.org/articles/PMC2890783/