Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Vitaly Kuryavyi"'
Autor:
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in inte
Externí odkaz:
https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
Autor:
Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S Taylor, Dinshaw J Patel, Peter M Burgers, Jennifer A Cobb, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://doaj.org/article/388c6d982e6748dbb8481de967c8f5ac
Autor:
Olga Rechkoblit, Lucy Malinina, Yuan Cheng, Vitaly Kuryavyi, Suse Broyde, Nicholas E Geacintov, Dinshaw J Patel
Publikováno v:
PLoS Biology, Vol 4, Iss 1, p e11 (2006)
7,8-dihydro-8-oxoguanine (oxoG), the predominant lesion formed following oxidative damage of DNA by reactive oxygen species, is processed differently by replicative and bypass polymerases. Our kinetic primer extension studies demonstrate that the byp
Externí odkaz:
https://doaj.org/article/0fb18b0ddf2741d4beb478a569725a93
Autor:
Pascal Maguin, Luciano A. Marraffini, Kevin Kao, Jakob T. Rostøl, Dinshaw J. Patel, Vitaly Kuryavyi, Ruby Froom, Wei Xie
Publikováno v:
Nature
In the type III CRISPR–Cas immune response of prokaryotes, infection triggers the production of cyclic oligoadenylates that bind and activate proteins that contain a CARF domain1,2. Many type III loci are associated with proteins in which the CRISP
Autor:
Haitao Miao, Changdong Liu, Yuning Hong, Dick Yan Tam, Pik Kwan Lo, Naining Xu, Yingying You, Xiao Shi, Bo Zhou, Yanyan Geng, Guang Zhu, Rui Feng, Vitaly Kuryavyi, Ben Zhong Tang
Publikováno v:
Chemical Science. 10:218-226
Guanine tracts of human telomeric DNA sequences are known to fold into eight different four-stranded structures that vary by the conformation of guanine nucleotides arranged in the stack of G-tetrads in their core and by different kinds and orders of
Autor:
Jennifer A. Cobb, Peter M. J. Burgers, John H.J. Petrini, Barry S. Taylor, Fiorella Ghisays, Marcel Hohl, Dinshaw J. Patel, Matthew T. Chang, Sarem Hailemariam, Vitaly Kuryavyi, Kyle Sorenson, Aditya Mojumdar
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb38763df458c0e79dd3ff038d72d01
Autor:
J. Fraser Glickman, Dinshaw J. Patel, Andrew John Jennings, Vitaly Kuryavyi, Aida Jumpei, Pu Gao, Mayako Michino, Wei Xie, Carolina Adura, Takanobu Kuroita, Lavoisier Ramos-Espiritu, Peter T. Meinke, Michael Miller, Toshihiro Imaeda, L. Lama, Kamei Taku, Thomas Tuschl, Tasos Gogakos, Hashizume Shogo, Rei Okamoto, Andrew Stamford, Asano Yasutomi, Joshua Steinberg, Daisuke Tomita
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the en
Publikováno v:
Structure. 20:2090-2102
Summary Neisseria gonorrhoeae is an obligate human pathogen that can escape immune surveillance through antigenic variation of surface structures such as pili. A G-quadruplex-forming (G4) sequence (5′-G 3 TG 3 TTG 3 TG 3 ) located upstream of the N
Autor:
Dinshaw J. Patel, Vitaly Kuryavyi, Alessandro Ruggiero, Prabodhika Mallikaratchy, William F. Maguire, David A. Scheinberg, Mark L. Heaney, Michael R. McDevitt, Jeffrey R. Gardner
Publikováno v:
Nucleic Acids Research
Long-term survival still eludes most patients with leukemia and non-Hodgkin’s lymphoma. No approved therapies target the hallmark of the B cell, its mIgM, also known as the B-cell receptor (BCR). Aptamers are small oligonucleotides that can specifi
Publikováno v:
Nucleic Acids Research
Previous studies have demonstrated that nuclease hypersensitivity regions of several proto-oncogenic DNA promoters, situated upstream of transcription start sites, contain guanine-rich tracts that form intramolecular G-quadruplexes stabilized by stac