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pro vyhledávání: '"Vitali Margulis"'
Publikováno v:
Rare Tumors, Vol 8, Iss 4 (2016)
Rare Tumors
Rare Tumors
Because of the asymptomatic natural history of renal cell carcinoma (RCC), by the time a diagnosis is made, metastatic disease is present in about one third of the cases. Thus, the overall survival of patients with RCC remains poor. Ultimately up to
Autor:
James Brugarolas, Jeffrey A. Cadeddu, Allison Joyce, Vitali Margulis, Ananth J. Madhuranthakam, Qurratulain Yousuf, DK Dwivedi, Ivan Pedrosa, Payal Kapur, Michael Fulkerson, Asghar Hajibeigi, Aditya Bagrodia, Ze Zhang, Durga Udayakumar, Alberto Diaz de Leon, Yin Xi, Tao Wang, Matthew A. Lewis
Publikováno v:
Cancer Research. 79:1397-1397
Clear cell renal cell carcinoma (ccRCC) is primarily driven by mutation in von Hippel-Lindau (VHL) leading to constitutive hypoxia inducible factors (HIFs) upregulation promoting angiogenesis. ccRCC is the most aggressive and common histological subt