Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Vitali I. Tararov"'
Autor:
Cyril S. Alexeev, Irina V. Kulikova, Vitali I. Tararov, Sergei Gavryushov, Sergey N. Mikhailov
Publikováno v:
Advanced Synthesis & Catalysis. 360:3090-3096
Publikováno v:
Current protocols in nucleic acid chemistry. 72(1)
This unit describes preparation of N
Publikováno v:
Current Protocols in Nucleic Acid Chemistry. 72
This unit describes preparation of N6 -substituted adenosines (cytokinin nucleosides), a unique class of compounds with a wide spectrum of biological activities. Regioselective alkylation of N6 -acetyl-2',3',5'-tri-O-acetyladenosine with alkyl halide
Autor:
Vladimir E. Oslovsky, Sergey N. Mikhailov, Pieter Leyssen, Mikhail S. Drenichev, Johan Neyts, Vitali I. Tararov, Aloys Tijsma, Svetlana V. Kolyachkina
Publikováno v:
European Journal of Medicinal Chemistry. 90:406-413
In this study, we demonstrate that N(6)-isopentenyladenosine, which essentially is a plant cytokinin-like compound, exerts a potent and selective antiviral effect on the replication of human enterovirus 71 with an EC50 of 1.0 ± 0.2 μM and a selecti
Autor:
Sergey N. Mikhailov, Vladimir E. Oslovsky, Alexander O. Chizhov, Christophe Pannecouque, Vitali I. Tararov, Liang Sun, Pieter Leyssen, Mikhail S. Drenichev, Johan Neyts, Aloys Tijsma, Nikolay N. Kurochkin
Publikováno v:
European journal of medicinal chemistry. 111
Very recently, we demonstrated that N(6)-isopentenyladenosine, a cytokinin nucleoside, exerts a potent and selective antiviral effect on the replication of human enterovirus 71. The present study is devoted to the structure optimization of another na
Publikováno v:
Synthesis. 2011:2483-2489
A simple and efficient route to N 6 -acetyl-2′,3′,5′-tri- O-acetyladenosine ( 1)was developed based on selective N-deacetylation of pentaacetylatedadenosine 2 with methanol at room temperaturein the presence of imidazole. Preparative synthesis
Autor:
Eliso Solomko, Svetlana V. Kolyachkina, Georgy A. Romanov, Evgenia V. Stepanova, Sergey N. Mikhailov, Dmitry M. Krivosheev, Andrey N. Inshakov, Vitali I. Tararov, Cyril S. Alexeev
Publikováno v:
Collection of Czechoslovak Chemical Communications. 76:1361-1378
A series of N6-adenosine derivatives were synthesized by alkylation of N6-acetyl-2′,3′,5′-tri-O-acetyladenosine (1) with alkyl halides and alcohols. It was shown that propargyl derivative 2a is a good substrate for copper(I) catalyzed Huisgen [
Autor:
Sergey N. Mikhailov, Mikhail S. Drenichev, Vitali I. Tararov, Irina V. Kulikova, G. V. Bobkov
Publikováno v:
Synthesis. 2010:3827-3834
The stability of tetraisopropyldisiloxane-1,3-diyl (TIPDS) protectionin nucleosides in ammonia/amine solutions in methanol andethanol was studied. In ammonia-methanol at ambient temperaturesignificant partial cleavage of TIPDS was observed. When etha
Autor:
Vitali I. Tararov, Vasyl Andrushko, Gerd König, Armin Börner, Natalia Andrushko, Andrei Korostylev
Publikováno v:
Chirality. 22:534-541
Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long-term benefits. They are administered as d
Autor:
Natalia Andrushko, Vasyl Andrushko, Vitali I. Tararov, Andrei Korostylev, Gerd König, Armin Börner
Publikováno v:
European Journal of Organic Chemistry. 2008:840-846
The highly enantioselective hydrogenation of ethyl 5,5-dimethoxy-3-oxopentanoate (3) to ethyl 3-hydroxy-5,5-dimethoxypentanoate (4) – a key intermediate in the synthesis of pharmacologically important statin drugs – has been investigated. The ste