Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vita Ozola"'
Autor:
Vita Ozola, Linda Kinena
Publikováno v:
Chemistry of Heterocyclic Compounds. 56:60-66
A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa1c251f6b2950e186c8204ec82b795c
https://doi.org/10.1007/s10593-020-02623-6
https://doi.org/10.1007/s10593-020-02623-6
Autor:
Raitis Bobrovs, Michael J. Blackman, Aigars Jirgensons, Teodors Pantelejevs, Iveta Kanepe-Lapsa, Rimants Zogota, Kristaps Jaudzems, Chrislaine Withers-Martinez, Vita Ozola, Linda Kinena, Edgars Suna
Publikováno v:
European Journal of Medicinal Chemistry
Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6ad12bcd7c51a3acc912be3a3e7f90
Publikováno v:
Synthesis. 45:683-693
Chiral, nonracemic, N-unprotected amino acids were converted into the corresponding N-benzimidazol-2-yl derivatives by a sequential procedure involving initial formation of isothiocyanates, their reaction with arene-1,2-diamines, and cyclization–de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd0b0302fac790a7fa25707347984512
https://doi.org/10.1055/s-0032-1316849
https://doi.org/10.1055/s-0032-1316849
Autor:
Vita Ozola, Gundars Leitis, Linda Kinena, Aigars Jirgensons, Edgars Suna, Kristaps Jaudzems, Iveta Kanepe-Lapsa, Raitis Bobrovs
Publikováno v:
Archiv der Pharmazie. 351:1800151
The spread of drug-resistant malaria parasites urges the search for new antimalarial drugs. Malarial aspartic proteases - plasmepsins (Plms) - are differentially expressed in multiple stages of the Plasmodium parasite's lifecycle and are considered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f9eb3b638715ac1c292dccf42c8905
https://doi.org/10.1002/ardp.201800151
https://doi.org/10.1002/ardp.201800151
Autor:
Mark R. Player, Richard S. Pottorf, Vita Ozola, Naresh Chadha, Hadi Ghane, Martins Katkevics, Edgars Suna, Tor Regberg
Publikováno v:
Tetrahedron Letters. 44:175-178
A facile route to benzoxazoles has been developed using microwave-assisted dielectric heating. The ease of synthesis and workup allowed the parallel synthesis of a 48-membered library of benzoxazoles quickly and efficiently.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76aa4b01c27f2c1bba46263959d2c4df
https://doi.org/10.1016/s0040-4039(02)02495-4
https://doi.org/10.1016/s0040-4039(02)02495-4
Publikováno v:
Nucleosides and Nucleotides. 17:1983-1986
Methods of synthesis of 7–(2′,3′,5′-tri-O-acetyl-β-D-ribofuranosyl)-8-chloro-3-methylxanthine (5a) and l-methyl-3-isobutylxanthine (5b) were reported. Further nucleophilic displacement of chlorine has provided the corresponding 8-alkylamino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d94c474e0e78cb9fdd6a64511f729b1
https://doi.org/10.1080/07328319808004737
https://doi.org/10.1080/07328319808004737
Autor:
Vita Ozola, Andrejs Krasikovs
Publikováno v:
ChemInform. 44
Doxapram has long been used as intravenously–administered drug for treatment of acute respiratory insufficiency. As a part of our research program toward development of novel respiratory stimulants we were interested in synthesis of Doxapram analog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ab02d893519a803ee743d78afb0df2
https://doi.org/10.1002/chin.201347168
https://doi.org/10.1002/chin.201347168
Publikováno v:
ChemInform. 44
The title compound is found to be the most efficient reagent to promote the cyclization—desulfurization of thioureas, derived from amino acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93795a85b6d98fe04ab6745f3fced569
https://doi.org/10.1002/chin.201326113
https://doi.org/10.1002/chin.201326113
Publikováno v:
Tetrahedron Letters. 37:8621-8624
Ammonium 4-methylphenyl H -phosphonate 4c was used in the conversion of 5′- O -(dimethoxytrityl)-2′-deoxynucleoside derivatives 6 into the corresponding 3′- H -phosphonates 2 , which were isolated in a high state of purity and in high yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a71a2ac27c3b3c70f44f8c9b72e45df
https://doi.org/10.1016/0040-4039(96)01993-4
https://doi.org/10.1016/0040-4039(96)01993-4
Publikováno v:
Journal of Heterocyclic Chemistry. 32:863-866
Convenient methods for the preparation of 9-(β-D-ribofuranosyl) derivatives of 8-(2- and 3-thienyl)-2,6-diaminopurine and of 8-(2- and 3-furyl)-2,6-diaminopurine, which are potential antiviral agents has been worked out. The key step was a Pd(0)-cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc4bd14421d52cb8a7a88e24a994ebf
https://doi.org/10.1002/jhet.5570320331
https://doi.org/10.1002/jhet.5570320331