Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Vita M Golubovskaya"'
Autor:
Yapeng Gu, Jill Shea, Gloria Slattum, Matthew A Firpo, Margaret Alexander, Sean J Mulvihill, Vita M Golubovskaya, Jody Rosenblatt
Publikováno v:
eLife, Vol 4 (2015)
When epithelia become too crowded, some cells are extruded that later die. To extrude, a cell produces the lipid, Sphingosine 1-Phosphate (S1P), which activates S1P2 receptors in neighboring cells that seamlessly squeeze the cell out of the epitheliu
Externí odkaz:
https://doaj.org/article/6ecc487c72f740f38bdbf58b1f7720b4
Autor:
William G. Cance, Brian P. Eliceiri, Jisook Lee, Carl D. Morrison, Michael Yemma, Baotran Ho, Grace Huang, Vita M. Golubovskaya
PDF file - 41KB, The combination of Y15 and temozolomide decreases more significantly viability of U251 cells than each agent alone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a3e7076acdd6ec5210150da2698e47
https://doi.org/10.1158/1535-7163.22498914
https://doi.org/10.1158/1535-7163.22498914
Autor:
Shirley Xu, Hua Zhou, Feng Li, Yuehua Wei, Walter F. Bodmer, Vita M. Golubovskaya, Xianghong Liu, Xin Li, Djamila Ouaret, Lijun Wu, Robert Berahovich
Publikováno v:
Frontiers in Bioscience. 25:1765-1786
Placental alkaline phosphatase, PLAP encoded by ALPP gene in humans is mainly expressed in placenta and testis, and not expressed in any other normal tissues. PLAP is overexpressed in colorectal cancers which makes it an attractive target for CAR (ch
Autor:
Hizkia Harto, Robert Berahovich, Le Li, Michael Valentine, Lijun Wu, Vita M. Golubovskaya, Hua Zhou, Shirley Xu, Jinying Sun, Chengjing Liu
Publikováno v:
Frontiers in Bioscience. 25:270-282
Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated clinical success in treatment of B-cell hematologic cancers. In this study, we compared human Transferrin epitope tagged CAR-T cells with non-tagged CAR-T cells for cytotoxicity, I
Autor:
Hizkia Harto, Vita M. Golubovskaya, Robert Berahovich, Feng Li, Lijun Wu, Hua Zhou, Michael Valentine, John Sienkiewicz, Yanwei Huang, Shirley Xu, Jinying Sun
Publikováno v:
Biomedicines, Vol 9, Iss 1422, p 1422 (2021)
Biomedicines
Volume 9
Issue 10
Biomedicines
Volume 9
Issue 10
Multiple myeloma (MM) is a hematological cancer caused by abnormal proliferation of plasma cells in the bone marrow, and novel types of treatment are needed for this deadly disease. In this study, we aimed to develop novel CS1 CAR-T cells and bispeci
Autor:
Yanwei Huang, John Sienkiewicz, Jinying Sun, Liselle Guiang, Feng Li, Liming Yang, Lijun Wu, Vita M. Golubovskaya
Publikováno v:
Cancer Research. 82:2889-2889
BCMA antigen is overexpressed in multiple myeloma cells and has been shown to be a promising target for novel cellular and antibody therapeutics. The humanized BCMA (clone 4C8A) antibody that effectively targeted multiple myeloma in a CAR (chimeric a
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071601709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d82e06c4b71545858df68f5ecfe97d8
https://doi.org/10.1007/978-1-0716-0171-6_3
https://doi.org/10.1007/978-1-0716-0171-6_3
Autor:
Robert Berahovich, Kai Ding, Hua Zhou, Lijun Wu, Randal May, Dongfeng Qu, Vita M. Golubovskaya, Courtney W. Houchen, Sripathi M. Sureban, Edwin Bannerman-Menson, Shirley Xu
Publikováno v:
Cancers, Vol 12, Iss 1, p 54 (2019)
Cancers
Volume 12
Issue 1
Cancers
Volume 12
Issue 1
CAR-T (chimeric antigen receptor T cells) immunotherapy is effective in many hematological cancers
however, efficacy in solid tumors is disappointing. Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of c
however, efficacy in solid tumors is disappointing. Doublecortin-like kinase 1 (DCLK1) labels tumor stem cells (TSCs) in genetic mouse models of c
Autor:
Hizkia Harto, Yama A. Abassi, Brandon Lamarche, Vita M. Golubovskaya, Fabio Cerignoil, Lijun Wu, Biao Xi, Shirley Xu, Robert Berahovich, David Santa Ana, Hua Zhou, Jasper Guan, Yuehua Wei, Jian Guan
Publikováno v:
Journal of Visualized Experiments.
Chimeric antigen receptor (CAR) T-cell therapy for cancer has achieved significant clinical benefit for resistant and refractory hematological malignancies such as childhood acute lymphocytic leukemia. Efforts are currently underway to extend this pr
Autor:
Jasper Guan, Shirley Xu, Le Li, Lijun Wu, Robert Berahovich, Qumiao Xu, Hua Zhou, Vita M. Golubovskaya, Hizkia Harto
Publikováno v:
Frontiers in Bioscience. 23:2245-2254
T cells expressing Chimeric antigen receptors or CAR-T cells are used as a novel treatment against hematological and solid cancers. In this report, we designed CAR with glucocorticoid-induced TNFR-related protein (GITR) co-stimulatory domain to study