Výsledky vyhledávání - "Vita Dauksaite"

Akademický článek

Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling.

Autor: Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198492 (2018)

Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. The giant protein titin could serve as a therapeutic target, as its elastic properties are a main determinant of cardiac filling in d

Externí odkaz: https://doaj.org/article/441cee579c294cd1b25a4e8286c8ed79

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Proteome-wide quantitative RNA interactome capture (qRIC) identifies phosphorylation sites with regulatory potential in RBM20

Autor: Michael Gotthardt, Carlos H. Vieira-Vieira, Matthias Selbach, Vita Dauksaite

SummaryRNA-binding proteins (RBPs) are major regulators of gene expression at the post-transcriptional level. While many posttranslational modification sites in RBPs have been identified, little is known about how these modifications regulate RBP fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88abccd38ec07dfca2acaa4b69f1a0c0
https://doi.org/10.1101/2021.07.12.452044

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Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20

Autor: Carlos Henrique Vieira-Vieira, Vita Dauksaite, Anje Sporbert, Michael Gotthardt, Matthias Selbach

Publikováno v: Molecular Cell. 82:2069-2083.e8

Cellular mRNA-binding proteins (mRBPs) are major posttranscriptional regulators of gene expression. Although many posttranslational modification sites in mRBPs have been identified, little is known about how these modifications regulate mRBP function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd790ff8e152efd2337226a648ac9bba
https://doi.org/10.1016/j.molcel.2022.03.024

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Proteome-Wide Quantitative RNA Interactome Capture (qRIC) Identifies Phosphorylation Sites with Regulatory Potential in RBM20

Autor: Matthias Selbach, Carlos Henrique Vieira e Vieira, Michael Gotthardt, Vita Dauksaite

Publikováno v: SSRN Electronic Journal.

RNA-binding proteins (RBPs) are major regulators of gene expression at the post-transcriptional level. While many posttranslational modification sites in RBPs have been identified, little is known about how these modifications regulate RBP function.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c4ec3e67c116c492e001d9c418c2e9c
https://doi.org/10.2139/ssrn.3887801

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Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4

Autor: Vita, Dauksaite, Michael, Gotthardt

Publikováno v: Nucleic Acids Research

RNA-binding motif protein 20 (RBM20) is a cardiac splice regulator that adapts cardiac filling via its diverse substrates—including the sarcomeric protein titin. The molecular basis and regulation of RBM20-dependent exon exclusion are largely unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::327a81cff3786104576447fcef24d8b1
https://pubmed.ncbi.nlm.nih.gov/29518215

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RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

Publikováno v: Nature Medicine; Vol 18
Nature Medicine

Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional cloning using a previously characterized rat strain with alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4962b7f958fcc9197d21333f75fb9886

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RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing

Autor: Marieluise Kirchner, Nikolaus Rajewsky, Michael H. Radke, Matthias Heinig, Norbert Hubner, Michael Gotthardt, Martin Liss, Henrike Maatz, Marvin Jens, Stuart A. Cook, Sebastian Schafer, Carola Rintisch, Matthias Selbach, Paul J.R. Barton, Vita Dauksaite, Markus Landthaler, Eleonora Adami

Publikováno v: Journal of Clinical Investigation, 124, 8, pp. 3419-30
Journal of Clinical Investigation
Journal of Clinical Investigation, 124, 3419-30
The Journal of Clinical Investigation

Contains fulltext : 139221.pdf (Publisher’s version ) (Open Access) Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through alteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5e0ac4eda5764859e4a85a44dd8050
https://hdl.handle.net/2066/139221

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DNA-directed coupling of organic modules by multiple parallel reductive aminations and subsequent cleavage of selected DNA sequences

Autor: Morten Nielsen, Vita Dauksaite, Jørgen Kjems, Kurt V. Gothelf

Publikováno v: Nielsen, M, Dauksaite, V, Kjems, J & Gothelf, K V 2005, ' DNA-Directed Coupling of Organic Modules by Multiple Parallel Reductive Aminations and Subsequent Cleavage of Selected DNA Sequences ', Bioconjugate Chem., vol. 16, no. 4, pp. 981-985 .
Aarhus University

A new method for DNA-directed assembly of organic modules by multiple parallel reductive aminations is presented. Linear oligonucleotide-functionalized modules (LOMs) consist of a rigid oligo(phenylene ethynylene) backbone with two salicylaldehyde te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc0e9e5ca99348657d34d6ff86f458b
https://pubmed.ncbi.nlm.nih.gov/16029040

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The second RNA-binding domain of the human splicing factor ASF/SF2 is the critical domain controlling adenovirus E1A alternative 5'-splice site selection

Autor: Göran Akusjärvi, Vita Dauksaite

Publikováno v: The Biochemical journal. 381(Pt 2)

The human splicing factor ASF/SF2 (alternative splicing factor/splicing factor 2) is modular in structure with two RNA-binding domains (RBD1 and RBD2) and a C-terminal domain rich in arginine–serine dipeptide repeats. ASF/SF2 is an essential splici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c02fbf74ad410dd5dbdfebad8b442f9
https://pubmed.ncbi.nlm.nih.gov/15068396

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Precursor of human adenovirus core polypeptide Mu targets the nucleolus and modulates the expression of E2 proteins

Autor: David A. Matthews, G. E. Blair, Fiona J. Lawrence, Göran Akusjärvi, Vita Dauksaite, Tim W.R. Lee

Publikováno v: The Journal of general virology. 85(Pt 1)

We have examined the subcellular localization properties of human adenovirus 2 (HAdV-2) preMu and mature Mu (pX) proteins as fusions with enhanced green fluorescence protein (EGFP). We determined that preMu is exclusively a nucleolar protein with a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865e2667880465122e4264c2504849d8
https://pubmed.ncbi.nlm.nih.gov/14718634

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