Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Viswanathan Chandrasekaran"'
Autor:
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Publikováno v:
eLife, Vol 10 (2021)
Ribosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of the conserved peptidyl transferase center (PTC) of the human mitochond
Externí odkaz:
https://doaj.org/article/106fc996871f4057b4c0bf076ebadc96
Autor:
Yen-Li Li, Viswanathan Chandrasekaran, Stephen D Carter, Cora L Woodward, Devin E Christensen, Kelly A Dryden, Owen Pornillos, Mark Yeager, Barbie K Ganser-Pornillos, Grant J Jensen, Wesley I Sundquist
Publikováno v:
eLife, Vol 5 (2016)
TRIM5 proteins are restriction factors that block retroviral infections by binding viral capsids and preventing reverse transcription. Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (cyclophilin A), which interact w
Externí odkaz:
https://doaj.org/article/a0f567d64d244ee9bfcd2b7434db5fbe
Akademický článek
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Autor:
Eva Absmeier, Viswanathan Chandrasekaran, Francis J O’Reilly, James AW Stowell, Juri Rappsilber, Lori A Passmore
Publikováno v:
bioRxiv
Eukaryotic messenger RNA (mRNA) decay is generally initiated by removal of the 3’ polyadenosine (poly(A)) tail by the CCR4-NOT complex. Yeast Ccr4-Not binds and ubiquitinates ribosomes stalled on mRNAs with sub-optimal codons to trigger deadenylati
Autor:
Jon Price, Eric A. Miska, Viswanathan Chandrasekaran, Venki Ramakrishnan, Nick Burton, Hanting Yang, Nirupa Desai
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Funder: Agouron Institute
Funder: Louis-Jeantet Foundation
Ribosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of t
Funder: Louis-Jeantet Foundation
Ribosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of t
Autor:
Hanting Yang, Razina Kazi, Michal Minczuk, Viswanathan Chandrasekaran, Nirupa Desai, Venki Ramakrishnan
Publikováno v:
Science
Quality control in mitochondria Human mitochondria have their own genome and ribosomes called mitoribosomes that respectively encode and synthesize essential subunits of complexes that use the energy from the oxidation of metabolites to drive the syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e21228399a271a17f1a19427e2f9afa
Autor:
Ivana Gasic, Viswanathan Chandrasekaran, Sichen Shao, Ramanujan S. Hegde, Zhewang Lin, Timothy J. Mitchison, Niklas Peters
Publikováno v:
Science
Cell Res
Cell Res
Mechanism of tubulin autoregulation Cells tightly control the abundance of key housekeeping factors, such as ribosomes and chaperones, to maintain them at optimal levels needed for homeostasis. Most abundance control mechanisms involve feedback regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a695974e6ab42103d76764e72e7fde43
https://europepmc.org/articles/PMC6942541/
https://europepmc.org/articles/PMC6942541/
Autor:
Venki Ramakrishnan, Sebastian Kraatz, Szymon Juszkiewicz, Viswanathan Chandrasekaran, Ramanujan S. Hegde, Zhewang Lin
Publikováno v:
Molecular Cell
Summary Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and ubiquitinates stalled ribosomes selectively is unclear. Here
Autor:
Jacint G. Sanchez, Viswanathan Chandrasekaran, Wesley I. Sundquist, Jordan M. Welker, Katarzyna Okreglicka, Owen Pornillos
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2494-2499
Tripartite motif (TRIM) proteins make up a large family of coiled-coil-containing RING E3 ligases that function in many cellular processes, particularly innate antiviral response pathways. Both dimerization and higher-order assembly are important ele