Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Viswanatham Katta"'
Autor:
Viswanatham Katta, Jennifer Zhang, Judy Yi-Huei Chang, Ed Hoff, Steven J. Shire, Stephen J. Russell, Nina J. Xiao, Min Zhu
Publikováno v:
Pharmaceutical Research. 27:2402-2413
To investigate the cause of the observed instability of dulanermin in 100 ml polyolefin (PO) infusion bags containing saline. Diluted dulanermin in IV bags was collected and frozen prior to analysis by size exclusion chromatography. The UV absorption
Autor:
Boyan Zhang, Hongbin Liu, Viswanatham Katta, Kathleen Francissen, Amy Shen, Charlene Li, Yi Yang, Alex Strahan, Jun Ouyang
Publikováno v:
mAbs. 2:285-298
A systematic analytical approach combining tryptic and chymotryptic peptide mapping with a Mascot Error Tolerant Search (ETS) has been developed to detect and identify low level protein sequence variants, i.e., amino acid substitutions, in recombinan
Autor:
Kevin McDorman, Michelle Simpson, Eileen T. Duenas, Carl Ng, Amy Kim, Siao Ping Tsai, Jihong Yang, Richard Vandlen, Helga Raab, Paul Polakis, William Mallet, Viswanatham Katta, Richard H. Scheller, Sunil Bhakta, Mark S. Dennis, Suzanna Clark, Henry B. Lowman, Yvonne Chen, Wai Lee Wong, Jeffrey Gorrell, Chien C Lee, Y Gloria Meng, Jagath Reddy Junutula, Yanmei Lu, Douglas D. Leipold, Sylvia Weir, Sarajane Ross, Kelly Flagella, Susan D. Spencer, Mark X. Sliwkowski, Rayna Venook
Publikováno v:
Nature Biotechnology. 26:925-932
Antibody-drug conjugates enhance the antitumor effects of antibodies and reduce adverse systemic effects of potent cytotoxic drugs. However, conventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeutic ind
Autor:
Viswanatham Katta, Boyan Zhang, Patrick McKay, Yi Yang, Mark S. Dennis, Charles Eigenbrot, Roger Pai, Inn H. Yuk, Kathleen Francissen
Publikováno v:
Analytical Chemistry. 80:2379-2390
Biotechnological companies and regulatory agencies are pursuing the complete characterization of protein therapeutics in every detail as a means to mitigate risks of product quality related safety issues. During the characterization of a recombinant
Autor:
Viswanatham Katta, Steven Kahn, Teresa L. Burgess, Robert Vassar, Paul Denis, Elizabeth A. Mendiaz, Martin Citron, Gary Rogers, Janis Fuller, Brian D. Bennett, Sandra Ross, Yunjen Young, Mitsuru Haniu, John O. Hui
Publikováno v:
Journal of Biological Chemistry. 275:21099-21106
The cerebral deposition of amyloid beta-peptide is an early and critical feature of Alzheimer's disease. Amyloid beta-peptide is released from the amyloid precursor protein by the sequential action of two proteases, beta-secretase and gamma-secretase
Publikováno v:
Journal of Chromatography A. 867:151-160
Immobilized proteolytic enzyme cartridges were used to rapidly digest neu differentiation factor EGF domain in order to obtain improved peptide maps useful for assignment of disulfide linkages. The procedure described here involves an on-line digesti
Publikováno v:
Analytical Chemistry. 70:4410-4416
In matrix-assisted laser desorption/ionization of proteins, there exists a certain amount of fast metastable decay immediately after laser irradiation. The fragment ions thus formed can be resolved and their m/z values measured accurately by employin
Publikováno v:
Annals of the New York Academy of Sciences. 841:104-107
Autor:
Yueh-Rong Hsu, Morris Charles F, Viswanatham Katta, Sylvia Hu, Julia Tseng, David W. Brankow, Hsu Eric W, Hsieng Sen Lu, William C. Kenney
Publikováno v:
Protein Expression and Purification. 12:189-200
Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that acts specifically on epithelial cells in a paracrine mode. We employed a mammalian expression system to synthesize recombinant human KGF and isolated two prepara
Autor:
Tamer Eris, Jennifer Liu, Viswanatham Katta, Keith R. Westcott, Linda O. Narhi, Kan V. Lu, Hsieng Sen Lu
Publikováno v:
Pharmaceutical Research. 15:632-640
Purpose. To investigate the role and importance of the four methionines in recombinant human leptin, and the effect of methionine oxidation in leptin structural stability and biological activity. Methods. Oxidized leptin derivatives were prepared in