Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Viswambharan, H"'
Autor:
Maqbool, A, Watt, N, Haywood, N, Viswambharan, H, Skromna, A, Makava, N, Visnagri, A, Shawer, HM, Bridge, K, Muminov, SK, Griffin, K, Beech, DJ, Wheatcroft, SB, Porter, KE, Simmons, KJ, Sukumar, P, Shah, AM, Cubbon, RM, Kearney, MT, Yuldasheva, NY
Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we examine the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::46075043e9cc4f8e95f89247d9a8e50b
Autor:
Sengupta, A, Patel, PA, Yuldasheva, NY, Mughal, RS, Galloway, S, Viswambharan, H, Walker, AMN, Aziz, A, Smith, J, Ali, N, Mercer, BN, Imrie, H, Sukumar, P, Wheatcroft, SB, Kearney, MT, Cubbon, RM
Publikováno v:
Endocrinology
Reduced systemic insulin signaling promotes endothelial dysfunction and diminished endogenous vascular repair. We investigated whether restoration of endothelial insulin receptor expression could rescue this phenotype. Insulin receptor knockout (IRKO
Akademický článek
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Autor:
Watt, N T, Gage, M C, Patel, P A, Viswambharan, H, Sukumar, P, Galloway, S, Yuldasheva, N Y, Imrie, H, Walker, A M N, Griffin, K J, Makava, N, Skromna, A, Bridge, K, Beech, D J, Schurmans, S, Wheatcroft, S B, Kearney, M T, Cubbon, R M
Publikováno v:
DIABETES
Shc homology 2–containing inositol 5′ phosphatase-2 (SHIP2) is a lipid phosphatase that inhibits insulin signaling downstream of phosphatidylinositol 3-kinase (PI3K); its role in vascular function is poorly understood. To examine its role in endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::b61f3e9cf3da9e725d42d3d3f70fa699
NOX2 NADPH-OXIDASE A NOVEL TARGET TO PREVENT INSULIN RESISTANCE RELATED ENDOTHELIAL CELL DYSFUNCTION
Autor:
Sukumar, P, Viswambharan, H, Imrie, H, Cubbon, RM, Yuldasheva, N, Gage, M, Galloway, S, Skromna, A, Smith, J, Gatenby, K, Beech, DJ, Wheatcroft, SB, Channon, KM, Shah, AM, Kearney, MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d620317bf8277259e25d7057ca679122
https://doi.org/10.1136/heartjnl-2012-301877b.105
https://doi.org/10.1136/heartjnl-2012-301877b.105
Autor:
Sukumar, P, Viswambharan, H, Imrie, H, Cubbon, R, Yuldasheva, N, Gage, M, Galloway, S, Skromna, A, Kandavelu, P, Santos, C, Gatenby, K, Smith, J, Beech, D, Wheatcroft, S, Channon, K, Shah, A, Kearney, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b126bd02c8774568159b8ec0296f7d5c
https://doi.org/10.1136/heartjnl-2013-304019.278
https://doi.org/10.1136/heartjnl-2013-304019.278
Akademický článek
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Akademický článek
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Autor:
Imrie, H, Viswambharan, H, Sukumar, P, Abbas, A, Cubbon, RM, Yuldasheva, N, Gage, M, Smith, J, Galloway, S, Skromna, A, Rashid, ST, Futers, TS, Xuan, S, Gatenby, VK, Grant, PJ, Channon, KM, Beech, DJ, Wheatcroft, SB, Kearney, MT
Publikováno v:
Diabetes. 61(9)
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R
Autor:
Abbas, A, Imrie, H, Viswambharan, H, Sukumar, P, Rajwani, A, Cubbon, RM, Gage, MC, Smith, J, Galloway, S, Yuldeshava, N, Kahn, M, Xuan, S, Grant, PJ, Channon, KM, Beech, DJ, Wheatcroft, SB, Kearney, MT
OBJECTIVE—In mice, haploinsufficiency of the IGF-1 receptor (IGF-1R+/2), at a whole-body level, increases resistance to inflammation and oxidative stress, but the underlying mechanisms are unclear. We hypothesized that by forming insulin-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e1f8fad3fd1270a0a0375717130caed6