ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.

Autor: Lee JJY; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Tao R; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., You Z; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Haldipur P; Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Erickson AW; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Farooq H; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Hendriske LD; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Abeysundara N; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Richman CM; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Wang EY; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Das Gupta N; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hadley J; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Batts M; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Mount CW; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Wu X; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Texas Children's Cancer and Hematology Center, Houston, TX, USA.; Department of Pediatrics-Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., Rasnitsyn A; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Bailey S; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Cavalli FMG; Inserm, Paris, France.; Institut Curie, PSL Research University, Paris, France.; MINES ParisTech, CBIO-Centre for Computational Biology, PSL Research University, Paris, France., Morrissy S; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada., Garzia L; Department of Surgery, McGill University and RI-MUHC Cancer Research Program, Montreal, Quebec, Canada., Michealraj KA; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Visvanathan A; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Fong V; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Palotta J; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Suarez R; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Livingston BG; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Liu M; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Luu B; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Daniels C; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Texas Children's Cancer and Hematology Center, Houston, TX, USA.; Department of Pediatrics-Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA., Loukides J; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Bendel A; Department of Pediatric Hematology-Oncology, Children's Hospital of Minnesota, Minneapolis, MN, USA., French PJ; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands., Kros JM; Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands., Korshunov A; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kool M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK), Heidelberg, Germany.; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.; Utrecht University Medical Center (UMCU), Utrecht, the Netherlands., Chico Ponce de León F; Department of Neurosurgery, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico., Perezpeña-Diazconti M; Department of Pathology, Instituto Nacional de Pediatria, Mexico City, Mexico., Lach B; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Singh SK; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Leary SES; Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA, USA., Cho BK; Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea., Kim SK; Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea., Wang KC; Neuro-Oncology Clinic, National Cancer Center, Goyang, Republic of Korea., Lee JY; Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea., Tominaga T; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan., Weiss WA; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Phillips JJ; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA., Dai S; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Zadeh G; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Saad AG; Department of Pediatric Pathology and Neuropathology, University of Miami Miller School of Medicine, Miami, FL, USA., Bognár L; Department of Neurosurgery, University of Debrecen, Debrecen, Hungary., Klekner A; Department of Neurosurgery, University of Debrecen, Debrecen, Hungary., Pollack IF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hamilton RL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ra YS; Department of Neurosurgery, University of Ulsan Asan Medical Center, Ulsan, Republic of Korea., Grajkowska WA; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland., Perek-Polnik M; Department of Oncology, The Children's Memorial Health Institute, Warsaw, Poland., Thompson RC; Department of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN, USA., Kenney AM; Department of Pediatrics, Emory University, Atlanta, GA, USA., Cooper MK; Department of Neurology, Vanderbilt Medical Center, Nashville, TN, USA., Mack SC; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Jabado N; Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Lupien M; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Gallo M; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Suva ML; Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Suzuki H; Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan., Millen KJ; Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Huang LF; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. huang.frank@mayo.edu.; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. huang.frank@mayo.edu., Northcott PA; Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org., Taylor MD; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. mdt.cns@gmail.com.; Texas Children's Cancer and Hematology Center, Houston, TX, USA. mdt.cns@gmail.com.; Department of Pediatrics-Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.; Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA. mdt.cns@gmail.com.

Publikováno v: Nature genetics [Nat Genet] 2025 Jan 03. Date of Electronic Publication: 2025 Jan 03.