Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Visvaldas Kairys"'
Autor:
Dovile Zebrauskiene, Egle Sadauskiene, Justas Dapkunas, Visvaldas Kairys, Joris Balciunas, Aleksandras Konovalovas, Ruta Masiuliene, Gunda Petraityte, Nomeda Valeviciene, Mindaugas Mataciunas, Jurate Barysiene, Violeta Mikstiene, Migle Tomkuviene, Egle Preiksaitiene
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Tatton-Brown–Rahman syndrome (TBRS) is a rare congenital genetic disorder caused by autosomal dominant pathogenic variants in the DNA methyltransferase DNMT3A gene. Typical TBRS clinical features are overgrowth, intellectual disability, an
Externí odkaz:
https://doaj.org/article/1c9dd59da3c14eceb348640c7603e7f9
Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
Autor:
Benas Balandis, Tomas Šimkūnas, Vaida Paketurytė-Latvė, Vilma Michailovienė, Aurelija Mickevičiūtė, Elena Manakova, Saulius Gražulis, Sergey Belyakov, Visvaldas Kairys, Vytautas Mickevičius, Asta Zubrienė, Daumantas Matulis
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 477 (2022)
A series of novel benzenesulfonamide derivatives were synthesized bearing para-N β,γ-amino acid or para-N β-amino acid and thiazole moieties and their binding to the human carbonic anhydrase (CA) isozymes determined. These enzymes are involved in
Externí odkaz:
https://doaj.org/article/f29f16b8eaf94ff5bab9d34b0a108e9f
Autor:
Ashok Aspatwar, Visvaldas Kairys, Sangeetha Rala, Mataleena Parikka, Murat Bozdag, Fabrizio Carta, Claudiu T. Supuran, Seppo Parkkila
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5153 (2019)
The genome of Mycobacterium tuberculosis (Mtb) encodes three β-carbonic anhydrases (CAs, EC 4.2.1.1) that are crucial for the life cycle of the bacterium. The Mtb β-CAs have been cloned and characterized, and the catalytic activities of the enzymes
Externí odkaz:
https://doaj.org/article/1b1e88fba5d64bbfbf6b8f42b60c33b0
Autor:
Vytautas Raškevičius, Valeryia Mikalayeva, Ieva Antanavičiūtė, Ieva Ceslevičienė, Vytenis Arvydas Skeberdis, Visvaldas Kairys, Sergio Bordel
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190636 (2018)
In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes) and the compounds contained in the DrugBank data
Externí odkaz:
https://doaj.org/article/5f6f2bc6f1eb4c07a8cb594ade95dc71
Autor:
Miglė Kišonaitė, Asta Zubrienė, Edita Capkauskaitė, Alexey Smirnov, Joana Smirnovienė, Visvaldas Kairys, Vilma Michailovienė, Elena Manakova, Saulius Gražulis, Daumantas Matulis
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114106 (2014)
The early stage of drug discovery is often based on selecting the highest affinity lead compound. To this end the structural and energetic characterization of the binding reaction is important. The binding energetics can be resolved into enthalpic an
Externí odkaz:
https://doaj.org/article/02bd957a8189462b92173944f1ed285f
Publikováno v:
Journal of Materials Chemistry B. 11:2409-2416
In this work, the effects of apolar, chlorinated, and polar organic solvents on the activity and structure of glucose oxidase were theoretically and experimentally investigated.
Autor:
Elena Manakova, Aivaras Vaškevičius, Vaida Paketurytė, Virginija Dudutienė, Asta Zubrienė, Alexey Smirnov, Saulius Gražulis, Visvaldas Kairys, Daumantas Matulis, Vaida Juozapaitienė, Denis Baronas
Publikováno v:
European Biophysics Journal. 50:993-1011
Zinc-containing metalloenzyme carbonic anhydrase (CA) binds primary sulfonamides with extremely high, up to picomolar, affinity by forming a coordination bond between the negatively charged amino group and the zinc ion and making hydrogen bonds and h
Autor:
Miglė Tomkuvienė, Markus Meier, Diana Ikasalaitė, Julia Wildenauer, Visvaldas Kairys, Saulius Klimašauskas, Laura Manelytė
Publikováno v:
Nucleic acids research, Oxford : Oxford University Press, 2022, vol. 50, iss. 11, p. 6549-6561
Nucleic Acids Research
Nucleic Acids Research
Methylation of cytosine to 5-methylcytosine (mC) at CpG sites is a prevalent reversible epigenetic mark in vertebrates established by DNA methyltransferases (MTases); the attached methyl groups can alter local structure of DNA and chromatin as well a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd0bd5a4fc713e4e00868419e035a4b
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 88:939-947
Structures of proteins complexed with other proteins, peptides, or ligands are essential for investigation of molecular mechanisms. However, the experimental structures of protein complexes of interest are often not available. Therefore, computationa
Autor:
Fabio Di Francesco, Denise Biagini, D. Santalucia, Arno Kirchhain, Visvaldas Kairys, Daumantas Matulis, Federico Vivaldi, Asta Zubrienė, Andrea Bonini
Publikováno v:
Bioorganic chemistry. 115
Matrix metalloproteinases (MMPs) are an important factor in cancer progression and metastasis, especially gelatinases MMP-2 and MMP-9. A simple methodology for their detection and monitoring is highly desirable. Molecular probes have been very widely