Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

Autor: Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc

Externí odkaz: https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75

F39 Design of an adaptive randomized controlled phase 1B/2A trial of WVE-003 in participants with huntington’s disease

Autor: Vissia Viglietta, Xiao Shelley Hu, Danlin Xu, Stephen Lake, Elena Dale, Michael Panzara, Kenechi Ejebe, Ramakrishna Boyanapalli

Publikováno v: F: Clinical studies: case reports, observational studies and trials.

Background Huntington’s disease is caused by the expansion of CAG-repeats (≥36 repeats) in at least one copy of HTT gene that leads to the expression of mutant HTT (mHTT) protein. The unaffected copy of HTT gene encodes wild-type HTT (wtHTT) prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21b17d0a05850b6273e924dc546f2be1
https://doi.org/10.1136/jnnp-2021-ehdn.82

The API Generation program: Biomarker phenotyping of cognitively unimpaired participants screened in Generation study 1 and Generation study 2

Autor: Vissia Viglietta, Fonda Liu, Marie-Laure Rouzade-Dominguez, Marie-Emmanuelle Riviere, Yihan Sui, Udo Eichenlaub, Eric M. Reiman, Yuchen Chien, Ulf Neumann, Beth Borowsky, Matt Quinn, Nicholas Seneca, Ana Graf, Pilar Cazorla, Angelika Caputo

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02208c30f5767572fdf686900de1e5f2
https://doi.org/10.1002/alz.041143

ASSESSMENT OF CLINICAL MEANINGFULNESS OF ENDPOINTS IN THE GENERATION PROGRAM BY THE INSIGHTS TO MODEL ALZHEIMER’S PROGRESSION IN REAL LIFE (IMAP) STUDY

Autor: Anders Gustavsson, Jessica B. Langbaum, Vissia Viglietta, Vladimir Bezlyak, Pierre N. Tariot, C. Lopez Lopez, Ana Graf, Angelika Caputo, V Risson

Publikováno v: The Journal Of Prevention of Alzheimer's Disease. :1-5

We are launching the Insights to Model Alzheimer’s Progression in Real Life study in parallel with the Alzheimer Prevention Initiative Generation Program. This is a 5-year, multinational, prospective, longitudinal, non-interventional cohort study t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c7a23446eead75f97853dcb96d72c6
https://doi.org/10.14283/jpad.2018.49

P1‐607: INSIGHTS TO MODEL ALZHEIMER'S PROGRESSION IN REAL LIFE (IMAP): RATIONALE, OBJECTIVE, AND METHODOLOGY

Autor: Vissia Viglietta, V Risson, Spiros Tzivelekis, Aoife Callan, Vladimir Bezlyak, Ana Graf, Cristina Lopez-Lopez, Anders Gustavsson

Publikováno v: Alzheimer's & Dementia. 14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::841dddba399af6bd0790f21dbd1c2efe
https://doi.org/10.1016/j.jalz.2018.06.620