Metabolic dysregulation accelerates injury-induced joint degeneration, driven by local inflammation; an in vivo rat study

Autor: de Visser, Huub M., Mastbergen, Simon C., Kozijn, Anne E., Coeleveld, Katja, Pouran, Behdad, van Rijen, Mattie H., Lafeber, Floris P.J.G., Weinans, Harrie

Publikováno v: Journal of Orthopaedic Research, 36(3), 881. John Wiley and Sons Inc.

Evidence is growing for the existence of an obesity-related phenotype of osteoarthritis in which low-grade inflammation and a disturbed metabolic profile play a role. The contribution of an obesity-induced metabolic dysbalance to the progression of t

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https://dspace.library.uu.nl/handle/1874/376957

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Metabolic dysregulation accelerates injury-induced joint degeneration, driven by local inflammation; an in vivo rat study.

Autor: de Visser HM; Department of Orthopaedics, University Medical Center Utrecht, F.02.127, 3508 GA, Utrecht, 85500, The Netherlands.; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Mastbergen SC; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Kozijn AE; Department of Orthopaedics, University Medical Center Utrecht, F.02.127, 3508 GA, Utrecht, 85500, The Netherlands.; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Metabolic Health Research, TNO, Leiden, The Netherlands., Coeleveld K; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Pouran B; Department of Orthopaedics, University Medical Center Utrecht, F.02.127, 3508 GA, Utrecht, 85500, The Netherlands.; Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands., van Rijen MH; Department of Orthopaedics, University Medical Center Utrecht, F.02.127, 3508 GA, Utrecht, 85500, The Netherlands., Lafeber FPJG; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Weinans H; Department of Orthopaedics, University Medical Center Utrecht, F.02.127, 3508 GA, Utrecht, 85500, The Netherlands.; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2018 Mar; Vol. 36 (3), pp. 881-890. Date of Electronic Publication: 2017 Sep 20.