Genetic architecture reconciles linkage and association studies of complex traits.

Autor: Sidorenko J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. j.sidorenko@imb.uq.edu.au., Couvy-Duchesne B; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Sorbonne University, Paris Brain Institute-ICM, CNRS, INRIA, INSERM, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France., Kemper KE; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Moen GH; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; The Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia., Bhatta L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St Olavs Hospital, Trondheim, Norway., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Wang R; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Nolte IM; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Gordon S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Hayward C; MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Benjamin DJ; Human Genetics Department, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Behavioral Decision Making Group, Anderson School of Management, University of California Los Angeles, Los Angeles, CA, USA.; National Bureau of Economic Research, Cambridge, MA, USA., Cesarini D; National Bureau of Economic Research, Cambridge, MA, USA.; Department of Economics, New York University, New York, NY, USA.; Center for Experimental Social Science, New York University, New York, NY, USA., Evans DM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; The Frazer Institute, University of Queensland, Woolloongabba, Queensland, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Goddard ME; Centre for AgriBioscience, Agriculture Victoria, Bundoora, Victoria, Australia.; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria, Australia., Haley CS; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.; Coupland Craft Cider, Coupland, Northumberland, UK., Porteous D; MRC Human Genetics Unit, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Brumpton B; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. peter.visscher@uq.edu.au.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK. peter.visscher@uq.edu.au., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. l.yengo@imb.uq.edu.au.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2352-2360. Date of Electronic Publication: 2024 Oct 07.

Genome-wide fine-mapping improves identification of causal variants.

Autor: Wu Y; Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu, China.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Zheng Z; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Thibaut L; Institute of Rare Diseases, West China Hospital of Sichuan University, Chengdu, China.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia.; Biosciences Research Division, Department of Economic Development, Jobs, Transport and Resources, Bundoora, Victoria, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Goddard ME; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia.; Biosciences Research Division, Department of Economic Development, Jobs, Transport and Resources, Bundoora, Victoria, Australia., Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Zeng J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Publikováno v: Research square [Res Sq] 2024 Aug 07. Date of Electronic Publication: 2024 Aug 07.

Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank.

Autor: Kemper KE; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. k.kemper@uq.edu.au., Sidorenko J; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Wang H; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Hayes BJ; Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, QLD, Australia., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Keller MC; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., Goddard M; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, VIC, Australia.; Biosciences Research Division, Agriculture Victoria, Bundoora, VIC, Australia., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. peter.visscher@uq.edu.au.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK. peter.visscher@uq.edu.au.

Publikováno v: Nature communications [Nat Commun] 2024 May 06; Vol. 15 (1), pp. 3776. Date of Electronic Publication: 2024 May 06.

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Autor: Keaton JM; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. a.vaez@umcg.nl.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran. a.vaez@umcg.nl., Williams A; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Goleva SB; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.; Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Ioannina, Greece., Hellwege JN; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Young WJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Traylor M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK., Giri A; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA., Zheng Z; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zeng J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Chasman DI; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hwang SJ; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University, Boston, MA, USA., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Attia JR; Faculty of Health and Medicine, University of Newcastle, New Lambton Heights, Newcastle, New South Wales, Australia., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kristiansson K; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Schmidt R; Department of Neurology/Medical University Graz, Graz, Austria., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; University of Lübeck, Lübeck, Germany., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Risch L; Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.; Department of Laboratory Medicine, Dr. Risch Anstalt, Vaduz, Liechtenstein., Gyllensten U; Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Melander O; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden., Riese H; Interdisciplinary Center Psychopathology and Emotional Regulation (ICPE), Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Lu Y; Vanderbilt Genetic Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Sundström J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK.; Leicester NIHR Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Tuomilehto J; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Kutalik Z; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Trompet S; Department Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., van der Harst P; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ridker PM; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Giulianini F; Division of Preventive Medicine Brigham and Women's Hospital, Boston, MA, USA., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harris SE; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK., Deary IJ; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, Edinburgh, UK., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Keavney BD; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Manchester Heart Institute, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Campbell A; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Scott LJ; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boutin T; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Mamasoula C; Population Health Sciences Institute, Newcastle University, Newcastle, UK., Järvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Lehrstuhl für Epidemiologie, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Lakatta EG; Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Cucca F; Institute of Genetic and Biomedical Research, National Research Council (CNR), Monserrato, Italy., Hui J; Busselton Population Medical Research Institute, Perth, Western Australia, Australia.; School of Population and Global Health, The University of Western Australia, Nedlands, Western Australia, Australia., Knekt P; Population Health Unit, Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Enroth S; Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala, Uppsala University, Uppsala, Sweden., De Borst MH; Department of Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Polašek O; University of Split School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Catamo E; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Cocca M; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Spedicati B; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Waldenberger M; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Strachan DP; Population Health Sciences Institute St George's, University of London, London, UK., Laan M; Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Dörr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Kopavogur, Iceland., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Ruggiero D; IRCCS Neuromed, Pozzilli, Italy.; Institute of Genetics and Biophysics - 'A. Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Kolcic I; Algebra University College, Zagreb, Croatia.; Department of Public Health, University of Split School of Medicine, Split, Croatia., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Traglia M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Johnson AD; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; The Framingham Heart Study, Framingham, MA, USA., Newton-Cheh C; Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Sever PJ; International Centre for Circulatory Health, Imperial College London, London, UK., Poulter N; School of Public Health, Imperial College London, London, UK., Chambers JC; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Elosua R; Hospital del Mar Research Institute (IMIM), Barcelona, Spain.; CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain.; Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain., Siscovick D; New York Academy of Medicine, New York, NY, USA., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Institute of Genomics, University of Tartu, Tartu, Estonia., Strawbridge RJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Health Data Research UK, Glasgow, UK.; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio University Hospital, Kuopio, Finland., Hamsten A; Division of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Hottenga JJ; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands., de Geus E; Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Centre, Amsterdam, the Netherlands., Morris AD; Data Science, University of Edinburgh, Edinburgh, UK.; Health Data Research UK, London, UK., Palmer CNA; Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Milaneschi Y; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Marten J; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Wright A; Centre for Genomic and Experimental Medicine, IGC, University of Edinburgh, Edinburgh, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Howson JMM; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., O'Donnell CJ; VA Boston Healthcare System, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Spector T; Department of Twin Research, King's College London, London, UK., Nalls MA; Center for Alzheimer's and Related Dementias, NIA/NINDS, NIH, Bethesda, MD, USA.; Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA.; DataTecnica LLC, Washington, DC, USA., Simonsick EM; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Liu Y; Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., van Duijn CM; Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK., Danesh JN; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Human Genetics, The Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Menni C; Department of Twin Research and Genetic Epidemiology, London, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge, UK., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.; VA Atlanta Healthcare System, Decatur, GA, USA., Wilson PWF; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Cho K; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Denny JC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Levy D; Population Sciences Branch, NHLBI Framingham Heart Study, Framingham, MA, USA.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Edwards TL; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. todd.l.edwards@vumc.org., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. h.r.warren@qmul.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2024 May; Vol. 56 (5), pp. 778-791. Date of Electronic Publication: 2024 Apr 30.

Unravelling the complex causal effects of substance use behaviours on common diseases.

Autor: Xue A; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, NSW, 2010, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia., Zhu Z; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.; National Centre for Register-Based Research, Aarhus University, Aarhus V, 8210, Denmark., Wang H; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Zeng J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. jian.yang@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, 310024, China. jian.yang@westlake.edu.cn.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310024, China. jian.yang@westlake.edu.cn.

Publikováno v: Communications medicine [Commun Med (Lond)] 2024 Mar 12; Vol. 4 (1), pp. 43. Date of Electronic Publication: 2024 Mar 12.