Correlative imaging using super‐resolution fluorescence microscopy and soft X‐ray tomography at cryogenic temperatures provides a new way to assess virosome solutions for vaccine development

Autor: Claire Pizzey, Archana Jadhav, Maud Dumoux, Maria Harkiolaki, Chidinma A. Okolo, Vishwas D. Joshi, Patrick Phillips, Amanda A. McMurray

Publikováno v: Journal of Microscopy. 284:214-232

Active virosomes (AVs) are derivatives of viruses, broadly similar to 'parent' pathogens, with an outer envelope that contains a bespoke genome coding for four to five viral proteins capable of eliciting an antigenic response. AVs are essentially nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53f14c301b0129db1440649a10bd17b
https://doi.org/10.1111/jmi.13054

Ferrocenyl helquats: unusual chiral organometallic nonlinear optical chromophores

Autor: Bruce S. Brunschwig, Vishwas D. Joshi, Michael Jirásek, Sergio Sánchez, Radek Pohl, Benjamin J. Coe, Šárka Ramešová, Jan Vávra, Laura E. R. Buckley, Nick Van Steerteghem, Ivana Císařová, Daniela Rusanova, David Šaman, Lubomír Pospíšil, Dushant Khobragade, Filip Teplý, Koen Clays

Publikováno v: Buckley, L E R, Coe, B J, Rusanova-Naydenova, D, Sánchez, S, Jirásek, M, Joshi, V D, Vávra, J, Khobragade, D, Pospíšil, L, Ramešová, Š, Císařová, I, Šaman, D, Pohl, R, Clays, K, Van Steerteghem, N, Brunschwig, B S & Teplý, F 2017, ' Ferrocenyl helquats : Unusual chiral organometallic nonlinear optical chromophores ', Dalton Transactions, vol. 46, no. 4, pp. 1052-1064 . https://doi.org/10.1039/c6dt04347j

Three new dipolar cations have been synthesised, containing ferrocenyl (Fc) electron donor groups attached to helquat (Hq) acceptors. These organometallic Hq derivatives have been characterised as their TfO- salts by using various techniques includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43ff867345cdc60472548e1aec5690
https://pubmed.ncbi.nlm.nih.gov/28050611

Synthesis and antimicrobial evaluation of 2-(2-butyl- 4-chloro-1H-imidazol-5-yl-methylene)-substituted-benzofuran-3-ones

Autor: Bhaskar S. Dawane, Shankaraiah G. Konda, Namdev T. Khandare, Santosh S. Chobe, Baseer M. Shaikh, Ragini G. Bodade, Vishwas D. Joshi

Publikováno v: Organic Communications, Vol 3, Iss 2, Pp 22-29 (2010)

In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1-ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1H-imidazol-5-yl)methylene)benzofuran-3(2H)-one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::aa2719f4cbb4b26c0f6cab1585bc1b3d

Lipopolysaccharide-induced paw edema model for detection of cytokine modulating anti-inflammatory agents

Autor: Manju Kumari, Labonyamoy Kole, Vishwas D Joshi, Bhargavi N.L Vajja, Suresh Juluri, Ranjan Chakrabarti

Publikováno v: International Immunopharmacology. 4:901-909

Cytokines are critical to pathogenesis of inflammatory disorders. So inhibition of their action provides therapeutic benefits in various diseases. Although inhibition of inflammation caused by intraperitoneally administered LPS can identify cytokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ece0aeb9b460abf896366e4b94f36c
https://doi.org/10.1016/j.intimp.2004.04.007

Role of Caspase 1 in Murine Antibacterial Host Defenses and Lethal Endotoxemia

Autor: John R. Hebel, Vishwas D. Joshi, Dhananjaya V. Kalvakolanu, Jeffrey D. Hasday, Alan S. Cross

Publikováno v: Infection and Immunity. 70:6896-6903

Sepsis is thought to result from an exaggerated innate immune response to microbial components such as lipopolysaccharide (LPS), but the involvement of a specific mechanism(s) has not been identified. We studied the role of caspase 1 (Cas-1) in the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97ec2c789750fa29cf512a4b098814c
https://doi.org/10.1128/iai.70.12.6896-6903.2002