Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Vishwanath R. Lingappa"'
Autor:
Li Du, Fred Deiter, Mohamed S. Bouzidi, Jean-Noël Billaud, Graham Simmons, Prerna Dabral, Suganya Selvarajah, Anuradha F. Lingappa, Maya Michon, Shao Feng Yu, Kumar Paulvannan, Balaji Manicassamy, Vishwanath R. Lingappa, Homer Boushey, John R. Greenland, Satish K. Pillai
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for innovative therapies with high genetic barriers to resistance. Therefore, there is pronounced interest in identifying new pharmacological targets
Externí odkaz:
https://doaj.org/article/79ab0de07b364c94ac7a6dd37c12f9dd
Autor:
Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound fr
Externí odkaz:
https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea
Autor:
Lisa M. Galli, Marc O. Anderson, J. Gabriel Fraley, Luis Sanchez, Raymund Bueno, David N. Hernandez, Eva U. Maddox, Vishwanath R. Lingappa, Laura W. Burrus
Publikováno v:
Open Biology, Vol 11, Iss 6 (2021)
Wnt gradients elicit distinct cellular responses, such as proliferation, specification, differentiation and survival in a dose-dependent manner. Porcupine (PORCN), a membrane-bound O-acyl transferase (MBOAT) that resides in the endoplasmic reticulum,
Externí odkaz:
https://doaj.org/article/5dfa7dbe7b2a4b93821ea642f7bc0806
Publikováno v:
Viruses, Vol 13, Iss 3, p 451 (2021)
The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic barriers to the selection of drug-resistant viral variants. Targeting host proteins could
Externí odkaz:
https://doaj.org/article/f4c94f0e21e24b318946b9388d153204
Autor:
Robert Bowser, Jiyan An, Vishwanath R. Lingappa, Mengde Lu, Armin Akhavan, Jian Liu, Arie Gruzman
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 10, Pp 4051-4062 (2010)
We recently reported the presence of a novel 32 kDa protein immunoreactive to a copper, zinc superoxide dismutase (SOD1) antibody within the spinal cord of patients with amyotrophic lateral sclerosis (ALS). This unique protein species was generated b
Externí odkaz:
https://doaj.org/article/6bf963fa5a404ea98aca67d3c50af601
Autor:
Antonio E. Rusiñol, Ramanujan S. Hegde, Steven L. Chuck, Vishwanath R. Lingappa, Jean E. Vance
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 6, Pp 1287-1294 (1998)
One potential mechanism by which apolipoprotein (apo) B secretion is regulated is via transient pausing during translocation across the endoplasmic reticulum membrane. We have previously shown that translocation and secretion of full-length and trunc
Externí odkaz:
https://doaj.org/article/79aea77fb2e344e592506dc6eb9e3d39
Autor:
Anuradha F. Lingappa, Olayemi Akintunde, Connie Ewald, Markus Froehlich, Niloufar Ziari, Shao Feng Yu, Maya Michon, Suguna Mallesh, Jim Lin, Anatoliy Kitaygorodskyy, Dennis Solas, Jonathan C. Reed, Jaisri R. Lingappa, Andreas Mueller-Schiffmann, Carsten Korth, Dharma Prasad, Aysegul Nalca, Emily Ashton, Brad Fabbri, Emma Petrouski, Debendranath Dey, David Andrews, Vishwanath R. Lingappa
Two structurally-unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against monkeypox virus (MPXV) and human immunodeficiency virus (HIV) respectively, were studied for anti-canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b819f47aacf2e88dedce28b0b3a974
https://doi.org/10.1101/2022.09.28.509937
https://doi.org/10.1101/2022.09.28.509937
Publikováno v:
Trends in Neurosciences. 44:352-365
The ability of viruses to evolve several orders of magnitude faster than their host cells has enabled them to exploit host cellular machinery by selectively recruiting multiprotein complexes (MPCs) for their catalyzed assembly and replication. This h
Autor:
Svenja V. Trossbach, Shriya Sahu, Suganya Selvarajah, Andreas Müller-Schiffmann, Ana Raquel Moreira, Vishwanath R. Lingappa, Irina Soloviev, Ingrid Prikulis, Sebastian Hänsch, Carsten Korth, Rita Marreiros, Stefanie Weidtkamp-Peters
Publikováno v:
Proc Natl Acad Sci U S A
Neurodegenerative diseases feature specific misfolded or misassembled proteins associated with neurotoxicity. The precise mechanisms by which protein aggregates first arise in the majority of sporadic cases have remained unclear. Likely, a first crit
Autor:
Andreas Müller-Schiffmann, Felix Torres, Anatolly Kitaygorodskyy, Anand Ramani, Argyro Alatza, Sarah K. Tschirner, Ingrid Prikulis, Shaofeng Yu, Debendranath Dey, Suguna Mallesh, Dharma Prasad, Dennis Solas, Verian Bader, Annemieke Rozemuller, Selina Wray, Jay Gopalakrishnan, Roland Riek, Vishwanath R. Lingappa, Carsten Korth
Herpes virus infections are endemic and ubiquitous. While only rarely leading to overt encephalitis, subchronic or latent infections have been associated to a variety of conditions, including Alzheimers disease (AD). The cellular consequences of herp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68a74e74e31947d49a74e2310209962a
https://doi.org/10.1101/2021.09.11.459903
https://doi.org/10.1101/2021.09.11.459903