Reverse phase, ion exchange, HILIC and mix-mode chromatography for the determination of metformin and evogliptin in human plasma and pharmaceutical formulations

Autor: Pankaj M. Kharabe, Prasad P. Jumade, Pravin N. Khatale, Parimal P. Katolkar, Santosh R. Butle, Mahendra D. Kshirsagar, Vishal V. Pendharkar, Amol V. Sawale, Kalyani S. Choudhari

Publikováno v: Talanta Open, Vol 9, Iss , Pp 100274- (2024)

Separation and quantification of highly polar metformin (MTF) alone or in combination with dipeptidyl peptidase-4 inhibitors, such as evogliptin (EVG), sitagliptin, saxagliptin, vildagliptin, linagliptin and teneligliptin, specifically from human pla

Externí odkaz: https://doaj.org/article/37982483b6aa462c90112bac3d492b6e

First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults.

Autor: Prativadibhayankaram VS; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Lee LS; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore., Lye D; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore.; Yong Loo Lin School of Medicine, Singapore, Singapore.; Lee Kong Chian School of Medicine, Singapore, Singapore., Xiaoying X; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore., Nellore R; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Pendharkar V; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Hentze H; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Guan S; Hummingbird Bioscience, Singapore, Singapore., Ayers BJ; Hummingbird Bioscience, Singapore, Singapore., Seah SGK; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore., Chye H; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore., Talib NSN; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Kaliaperumal N; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Ong WY; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Wong ZX; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Au VB; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Alok A; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore., Connolly JE; Institute of Molecular and Cell Biology (IMCB), A*STAR Research Entities (ARES), Singapore, Singapore.; Institute of Biomedical Studies, Baylor University, Waco, TX, USA., Boyd-Kirkup JD; Hummingbird Bioscience, Singapore, Singapore., Ingram PJ; Hummingbird Bioscience, Singapore, Singapore., Hanson BJ; Hummingbird Bioscience, Singapore, Singapore., Ethirajulu K; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., O'Connell D; Experimental Drug Development Centre, A*STAR Research Entities (ARES), Singapore, Singapore., Chan CEZ; National Centre for Infectious Diseases, Tan Tock Seng Hospital, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore. conrad_ez_chan@ncid.sg.; Biological Defence Programme, DSO National Laboratories, Singapore, Singapore. conrad_ez_chan@ncid.sg.

Publikováno v: Infectious diseases and therapy [Infect Dis Ther] 2022 Oct; Vol. 11 (5), pp. 1999-2015. Date of Electronic Publication: 2022 Sep 04.

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

Autor: Kwiatkowski J; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Liu B; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Pang S; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Ahmad NHB; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Wang G; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Poulsen A; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Yang H; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Poh YR; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Tee DHY; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Ong E; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Retna P; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Dinie N; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Kwek P; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Wee JLK; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Manoharan V; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Low CB; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Seah PG; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Pendharkar V; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Sangthongpitag K; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Joy J; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Baburajendran N; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Jansson AE; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Nacro K; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Hill J; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Keller TH; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore., Hung AW; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR) , 10 Biopolis Way, Chromos #05-01/06 , 138670 Singapore.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Jan 23; Vol. 63 (2), pp. 621-637. Date of Electronic Publication: 2020 Jan 07.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Autor: Huang C; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Liew SS; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Lin GR; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Poulsen A; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Ang MJY; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Chia BCS; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Chew SY; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Kwek ZP; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Wee JLK; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Ong EH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Retna P; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Baburajendran N; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Li R; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Yu W; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Koh-Stenta X; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Ngo A; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Manesh S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Fulwood J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Ke Z; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Chung HH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Sepramaniam S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Chew XH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Dinie N; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Lee MA; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Chew YS; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Low CB; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Pendharkar V; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Manoharan V; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Vuddagiri S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Sangthongpitag K; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Joy J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Matter A; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Hill J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Keller TH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670., Foo K; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, Singapore 138670.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 May 23; Vol. 10 (6), pp. 978-984. Date of Electronic Publication: 2019 May 23 (Print Publication: 2019).

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Autor: Yang H; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Chennamaneni LR; Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), A*STAR , 8 Biomedical Grove, Neuros, #07-01 , 138665 Singapore., Ho MWT; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Ang SH; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Tan ESW; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Jeyaraj DA; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Yeap YS; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Liu B; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Ong EH; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Joy JK; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Wee JLK; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Kwek P; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Retna P; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Dinie N; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Nguyen TTH; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Tai SJ; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Manoharan V; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Pendharkar V; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Low CB; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Chew YS; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Vuddagiri S; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Sangthongpitag K; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Choong ML; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Lee MA; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Kannan S; Bioinformatics Institute (BII) , A*STAR , 30 Biopolis Street, #07-01 Matrix , 138671 Singapore., Verma CS; Bioinformatics Institute (BII) , A*STAR , 30 Biopolis Street, #07-01 Matrix , 138671 Singapore.; School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , 637551 Singapore.; Department of Biological Sciences , National University of Singapore , 14 Science Drive 4 , 117543 Singapore., Poulsen A; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Lim S; Duke-NUS Medical School , 8 College Road , 169857 Singapore., Chuah C; Duke-NUS Medical School , 8 College Road , 169857 Singapore., Ong TS; Duke-NUS Medical School , 8 College Road , 169857 Singapore.; Department of Medicine , Duke University Medical Center , Durham , North Carolina 27710 , United States., Hill J; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Matter A; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore., Nacro K; Experimental Therapeutics Centre (ETC) , A*STAR , 31 Biopolis Way, Nanos #03-01 , 138669 Singapore.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 May 24; Vol. 61 (10), pp. 4348-4369. Date of Electronic Publication: 2018 May 07.