Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Vishal S. Vaidya"'
Autor:
Kodihalli C. Ravindra, Vishal S. Vaidya, Zhenyu Wang, Joel D. Federspiel, Richard Virgen-Slane, Robert A. Everley, Jane I. Grove, Camilla Stephens, Mireia F. Ocana, Mercedes Robles-Díaz, M. Isabel Lucena, Raul J. Andrade, Edmond Atallah, Alexander L. Gerbes, Sabine Weber, Helena Cortez-Pinto, Andrew J. Fowell, Hyder Hussaini, Einar S. Bjornsson, Janisha Patel, Guido Stirnimann, Sumita Verma, Ahmed M. Elsharkawy, William J. H. Griffiths, Craig Hyde, James W. Dear, Guruprasad P. Aithal, Shashi K. Ramaiah
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distingui
Externí odkaz:
https://doaj.org/article/ec3315a517864777bd5bdde19a8b8aa2
Autor:
Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 264-277 (2022)
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz:
https://doaj.org/article/86125310200649c0a9c68fcd0e3733f4
Autor:
Cuiyan Xin, Jiahui Lei, Qian Wang, Yixia Yin, Xiaoqian Yang, Jose Alberto Moran Guerrero, Venkata Sabbisetti, Xiaoming Sun, Vishal S. Vaidya, Joseph V. Bonventre
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103193- (2021)
Summary: Chronic kidney disease (CKD) is associated with substantial morbidity and mortality. We developed a mouse model that mimics human CKD with inflammation, extracellular matrix deposition, tubulointerstitial fibrosis, increased proteinuria, and
Externí odkaz:
https://doaj.org/article/0191900a45db43debe2d94491ac0a6ab
Autor:
Mark E. Williams, Katherine R. Tuttle, Jing Liu, Jinghui Luo, Yougqun He, Laura Pyle, Blue B. Lake, Brad H. Rovin, Lynda Hayashi, Yuguang Xiong, Dennis G. Moledina, Andreas Bueckle, Steven Menez, Glenda V. Roberts, Anand Srivastava, Paul Appelbaum, Heather Ascani, Catherine Campbell, Stephanie M. Grewenow, Mark Aulisio, Jennifer Sun, Christopher R. Anderton, Jamie L. Marshall, Sharon Bledso, John P. Shapiro, Theodore Alexandrov, Richard M. Caprioli, Michele Elder, Leslie Cooperman, Shweta Bansal, Lakeshia Bush, Krzysztof Kiryluk, Mitchell Tublin, Olga G. Troyanskaya, Emilio D. Poggio, Kristina N. Blank, Andrew Janowczyk, Paul Hoover, Sabine M. Diettman, R. Tyler Miller, Katy Borner, Leonidas G. Alexopoulos, James Winters, Anant Madabhushi, Haojia Wu, Chirag R. Parikh, Yumeng Wen, Avi Z. Rosenberg, Agustin Gonzalez-Vicente, Leal Herlitz, Keith Brown, Matthew Gilliam, Joseph P. Gaut, Vidya S. Viswanathan, Karla Mehl, Stewart H. Lecker, Pierre C. Dagher, Dana C. Crawford, Camille Johansen, Anna Greka, Tiffany Shi, Ari Pollack, Renee Frey, Kavya Sharman, Isaac E. Stillman, Stuart J. Shankland, Ricardo Melo Ferreira, Jack Bebiak, Jing Su, Matthias Kretzler, Ellen Palmer, Yury Goltsev, Aaron K. Wong, Matthew R. Rosengart, Taneisha Campbell, Tina Vita, Helmut G. Rennke, Nir Hacohen, Satoru Kudose, Christine Limonte, Kun Zhang, Robyn L. McClelland, Ulysses J. Balis, Katherine J. Kelly, Simon Lee, Ninive C. Conser, Adele Rike, Frederick Dowd, Timothy A. Sutton, Steve Bogen, Petter M. Bjornstad, Zoltan Laszik, Dianbo Zhang, Benjamin D. Humphreys, Pinaki Sarder, Jeffrey M. Spraggins, Ravi Iyengar, Marcelino Rivera, Roy Pinkeney, James C. Williams, Tarek M. El-Achkar, Laura H. Mariani, Richard J. Knight, Manjeri A. Venkatachalam, Pietro A. Canetta, Lloyd G. Cantley, Kayleen Williams, Catherine P. Jayapandian, Edgar A. Otto, Jessica Lukowski, Kassandra Spates-Harden, Ashish Verma, John Saul, Tariq Mukatash, Mia R. Colona, Shana Maikhor, Laurence H. Beck, Titlayo Ilori, Charles E. Alpers, Ellen M. Quardokus, Mujeeb Basit, Dušan Veličković, Raf Van de Plas, Jonathan Himmelfarb, Michael T. Eadon, Chrysta Lienczewski, Christopher Y. Lu, Yijiang M. Chen, Kasra Rezaei, Richard Montellano, Pottumarthi V. Prasad, Francis P. Wilson, Christy Stutzke, Jane Nguyen, Kamalanathan K. Sambandam, Miguel A. Vazquez, Vishal S. Vaidya, Vivette D. D'Agati, Patrick Boada, Adam Wilcox, Astrid Weins, Jennifer A. Schaub, Harold Park, Kumar Sharma, M. Todd Valerius, Stephen Daniel, Sean Eddy, Bruce W. Herr, Kenneth W. Dunn, Jamie Snyder, E. Steve Woodle, Dianna Sendrey, Ljiljana Paša-Tolić, Raghavan Murugan, Brandon Ginley, Bryan Kestenbaum, Celia P. Corona-Villalobos, Olivia Balderes, Sushrut Waikar, Carissa Vinovskis, Brooke Berry, Parmjeet Randhawa, Seth Winfree, Jose R. Torrealba, Ning Shang, Rachel Sealfon, Michael J. Ferkowicz, William S. Bush, Jonas Carson, Robert Koewler, Guanshi Zhang, Robert D. Toto, Ian H. de Boer, Gearoid M. McMahon, Andrew N. Hoofnagle, Vijaykumar R. Kakade, Brendon Lutnick, Melissa M. Shaw, Rita R. Alloway, Rajasree Menon, Afolarin Amodu, Jeanine Basta, Paul J. Lee, Ingrid Onul, Sylvia E. Rosas, Cijang (John) He, Andrew S. Bomback, Yinghua Cheng, Jeffrey B. Hodgin, Samir M. Parikh, Garry Nolan, John A. Kellum, Anil Pillai, Annapurna Pamreddy, Orson W. Moe, Jiten Patel, Jonathan J. Taliercio, S. Susan Hedayati, Anitha Vijayan, Tanima Arora, Evren U. Azeloglu, Paul M. Palevsky, Nathan Heath Patterson, Asra Kermani, Becky Steck, Kavya Anjani, Ashley Berglund, Yashvardhan Jain, Stacey E. Jolly, John R. Sedor, George (Holt) Oliver, Natasha Wen, Nancy Wang, Ruikang Wang, Joseph Ardayfio, Michael Rauchman, Ashley R. Burg, Victoria Blanc, Minnie M. Sarwal, Daniel Hall, Sethu M. Madhavan, Sean D. Mooney, Sushrut S. Waikar, Daria Barwinska, Christopher Y. Park, Tara K. Sigdel, Ugochukwu Ugwuowo, John F. O'Toole, Ragnar Palsson, Insa M. Schmidt, Joel M. Henderson, Hongping Ye, Jens Hansen, Jonathan Barasch, Neil Roy, Nicholas Lucarelli, Anna Shpigel, Ashveena Dighe, Elizabeth Record, Sanjay Jain, Nichole Jefferson
Publikováno v:
Kidney Int
Kidney fibrosis constitutes the shared final pathway of nearly all chronic nephropathies, but biomarkers for the non-invasive assessment of kidney fibrosis are currently not available. To address this, we characterize five candidate biomarkers of kid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ae38ce2b077fd606d35920c4f3e3ec
https://doi.org/10.1016/j.kint.2021.04.037
https://doi.org/10.1016/j.kint.2021.04.037
Autor:
Craig L. Hyde, Gerd A. Kullak-Ublick, James W. Dear, Seda Arat, Vishal S. Vaidya, Jianying Wang, Guruprasad P. Aithal, Roscoe L. Warner, Heather P. Llewellyn, Shashi K. Ramaiah, Kent J. Johnson, David Potter, Katherine Masek-Hammerman, Zhenyu Wang, Matthew Martin, Qing Zong, Qinghai Peng
Publikováno v:
Toxicological Sciences
Early diagnosis of drug-induced liver injury (DILI) continues to be a major hurdle during drug development and postmarketing. The objective of this study was to evaluate the diagnostic performance of promising biomarkers of liver injury—glutamate d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2897aff8e080001361598cd0a9d4b5c
https://doi.org/10.1093/toxsci/kfab003
https://doi.org/10.1093/toxsci/kfab003
Autor:
Jiangwei Zhang, Kelly A. Fader, Shashi K. Ramaiah, Gary S. Friedman, Ravi Thadhani, Elliott M. Antman, Joseph P. Menetski, Vishal S. Vaidya
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Faced with the health and economic consequences of the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the biomedical community came together to identify, diagnose, prevent, and treat the novel disease at breathtaking s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478ff5ea5a12c86fe82000f20ca853b8
https://doi.org/10.1124/jpet.120.000204
https://doi.org/10.1124/jpet.120.000204
Autor:
Richard Goldstein, Jason Wang, Amulya Kaza, Neel K. Prabhu, Alastair Khodabukus, Nenad Bursac, Vishal S. Vaidya
Publikováno v:
Toxicol Sci
Traditional serum biomarkers used to assess skeletal muscle damage, such as activity of creatine kinase (CK), lack tissue specificity and sensitivity, hindering early detection of drug-induced myopathies. Recently, a novel four-factor skeletal muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73d4d5bc8b4d4fa3f8405ce90afdabd
https://doi.org/10.1093/toxsci/kfaa049
https://doi.org/10.1093/toxsci/kfaa049
Autor:
Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3887d189c54e6f093f86109ff2fb660f
https://doi.org/10.1101/2021.12.23.473896
https://doi.org/10.1101/2021.12.23.473896
Autor:
Hyun Jung Chung, Kathryn L Pellegrini, Jaehoon Chung, Kamani Wanigasuriya, Innocent Jayawardene, Kyungheon Lee, Hakho Lee, Vishal S Vaidya, Ralph Weissleder
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133417 (2015)
The high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these areas can be more challeng
Externí odkaz:
https://doaj.org/article/18b5907694d34a7caa3e1327b37d7cfe
Autor:
Shashi K. Ramaiah, Kathryn R. Wagner, Francesco Muntoni, M. Guglieri, Lawrence Charnas, Vishal S. Vaidya, Richard Goldstein, Shannon Marraffino, Michael Binks, Jeffrey P. Palmer
Publikováno v:
Biomarkers in medicine. 15(15)
Aim: Evaluate the utility of glutamate dehydrogenase (GLDH) and cardiac troponin I as safety biomarkers, and creatine kinase and muscle injury panel as muscle health biomarkers in Duchenne muscular dystrophy. Patients & methods: Data were collected d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b17f777a9027f18a7a0ba21665a41d5
https://pubmed.ncbi.nlm.nih.gov/34533053
https://pubmed.ncbi.nlm.nih.gov/34533053