Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Vishal R. Mali"'
Autor:
Vishal R Mali, Guodong Pan, Mandar Deshpande, Rajarajan A Thandavarayan, Jiang Xu, Xiao-Ping Yang, Suresh S Palaniyandi
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163158 (2016)
Aldehyde dehydrogenase (ALDH) 2 is a mitochondrial isozyme of the heart involved in the metabolism of toxic aldehydes produced from oxidative stress. We hypothesized that hyperglycemia-mediated decrease in ALDH2 activity may impair mitochondrial resp
Externí odkaz:
https://doaj.org/article/8a53ac263efb462da11bab8786db5064
Publikováno v:
Journal of Ayurveda and Integrative Medicine, Vol 3, Iss 2, Pp 75-79 (2012)
Background: In spite of advances in the present practice of medicine, the formation and growth of calculi continues to trouble mankind, as there is no satisfactory drug to treat kidney stones. In India, many indigenous drugs are in use for the treatm
Externí odkaz:
https://doaj.org/article/972a6007a1944658bf049dd807075b9c
Autor:
Souad Belmadani, Manal Mandour, Khalid Matrougui, Eman Radwan, Amira M. El-Noweihi, Jun Ren, Vishal R. Mali, Samuel Haddox
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:403-412
Background Microvascular dysfunction is a major complication in hypertensive patients. We previously reported that CD4+CD25+ T regulatory cells (Treg) play an important preventive role in hypertension-induced vascular dysfunction. However, whether Tr
Publikováno v:
Journal of Hypertension. 36:377-386
Objectives Stromal interacting molecule-1 (STIM1) plays a role in coordinating calcium signaling in different cell types. The increase or deletion of STIM1 expression in cardiomyocyte causes cardiac complication. Moreover, the deletion of STIM1 in en
Autor:
Suresh S. Palaniyandi, Xiao Ping Yang, Mandar Deshpande, Vishal R. Mali, Rajarajan Amirthalingam Thandavarayan, Jiang Xu, Guodong Pan
Publikováno v:
Cell Biochemistry and Function. 34:334-342
Increase in 4-hydroxy-2-nonenal (4HNE) due to oxidative stress has been observed in a variety of cardiac diseases such as diabetic cardiomyopathy. 4HNE exerts a damaging effect in the myocardium by interfering with subcellular organelles like mitocho
Publikováno v:
Pflugers Archiv : European journal of physiology. 470(3)
We previously reported that EGFR tyrosine kinase (EGFRtk) activity and endoplasmic reticulum (ER) stress are enhanced in type 2 diabetic (T2D) mice and cause vascular dysfunction. In the present study, we determined the in vivo contribution of EGFRtk
Publikováno v:
Experimental Biology and Medicine. 239:610-618
Reactive aldehydes such as 4-hydroxy-2-nonenal (4HNE) are generated in the myocardium in cardiac disease. 4HNE and other toxic aldehydes form adducts with proteins, leading to cell damage and organ dysfunction. Aldehyde dehydrogenases (ALDHs) metabol
Autor:
Suresh S. Palaniyandi, Vishal R. Mali
Publikováno v:
Free Radical Research. 48:251-263
4-Hydroxy-2-nonenal (4-HNE), a reactive aldehyde, is generated from polyunsaturated fatty acids (PUFAs) in biological membranes. Reactive oxygen species (ROS) generated during oxidative stress react with PUFAs to form aldehydes like 4-HNE, which inac
Autor:
Mohamed Trebak, Souad Belmadani, Mohanad Gabani, Karima Ait-Aissa, Modar Kassan, Khalid Matrougui, Kaikobad Irani, Wei Zhang, Samuel Haddox, Vishal R. Mali, Eman Radwan
Objectives— Chronic hypertension is the most critical risk factor for cardiovascular disease, heart failure, and stroke. Approach and Results— Here we show that wild-type mice infused with angiotensin II develop hypertension, cardiac hypertrophy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adbd42921ffec20de2afe1f48ffd231
https://europepmc.org/articles/PMC5061131/
https://europepmc.org/articles/PMC5061131/
Publikováno v:
Circulation Research. 119
Background: Stromal interacting molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum (ER). We previously reported that STIM1 plays opposing roles in vascular smooth muscle cells (SMC) vs. endothelial cell in the regulation of vascular