Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Vishal H. Oza"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer’s disease, it is kn
Externí odkaz:
https://doaj.org/article/8bb2bd0ed74f487fb8fd59b64dc9c11c
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Sam E. Gary, Timothy C. Howton, Victoria L. Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
Publikováno v:
FEBS Open Bio, Vol 14, Iss 5, Pp 803-830 (2024)
Drug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease‐associated gene signature to identi
Externí odkaz:
https://doaj.org/article/f40949cccc344b50a5660d71408edfbd
Publikováno v:
Cancer Reports, Vol 6, Iss 12, Pp n/a-n/a (2023)
Abstract Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive. Chromoso
Externí odkaz:
https://doaj.org/article/fc55d8f10ddf4e04996a60fab76d1f83
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Publikováno v:
PeerJ, Vol 11, p e15244 (2023)
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological
Externí odkaz:
https://doaj.org/article/2b7bda82b19e4b839625dc19ae09106b
Autor:
Vishal H Oza, Jordan H Whitlock, Elizabeth J Wilk, Angelina Uno-Antonison, Brandon Wilk, Manavalan Gajapathy, Timothy C Howton, Austyn Trull, Lara Ianov, Elizabeth A Worthey, Brittany N Lasseigne
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010749 (2023)
With an increasing amount of biological data available publicly, there is a need for a guide on how to successfully download and use this data. The 10 simple rules for using public biological data are: (1) use public data purposefully in your researc
Externí odkaz:
https://doaj.org/article/e2f1a4d14283452ea313b1f657253d45
Publikováno v:
bioRxiv
BackgroundCancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive. Chromosomal instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccdf3b33e7821ec7e105d7d50b2fddf
https://europepmc.org/articles/PMC10245901/
https://europepmc.org/articles/PMC10245901/
Publikováno v:
Briefings in Functional Genomics.
Following the central dogma of molecular biology, gene expression heterogeneity can aid in predicting and explaining the wide variety of protein products, functions and, ultimately, heterogeneity in phenotypes. There is currently overlapping terminol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3055c33d6a65fb9e4afeba42a7822e7
https://doi.org/10.1093/bfgp/elad019
https://doi.org/10.1093/bfgp/elad019
SummaryHigh throughput sequencing technologies have enabled cross-species comparative transcriptomic studies; however, there are numerous challenges for these studies due to biological and technical factors. We developed CoSIA (Cross-Species Investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93411d3e4521553601b2bc5be2fbf2d
https://doi.org/10.1101/2023.04.21.537877
https://doi.org/10.1101/2023.04.21.537877
Autor:
Jennifer L. Fisher, Elizabeth J. Wilk, Vishal H. Oza, Timothy C. Howton, Victoria Flanary, Amanda D. Clark, Anita B. Hjelmeland, Brittany N. Lasseigne
SummaryDrug repurposing is promising because approving a drug for a new indication requires fewer resources than approving a new drug. Signature reversion detects drug perturbations most inversely related to the disease-associated gene signature to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78caf3d321d57b53aa5edd823145c1f8
https://doi.org/10.1101/2023.03.10.532074
https://doi.org/10.1101/2023.03.10.532074