Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Vishakha Karnawat"'
Publikováno v:
Biochemistry. 55:2491-2499
In enzymes that conduct complex reactions involving several substrates and chemical transformations, the active site must reorganize at each step to complement the transition state of that chemical step. Adenylosuccinate synthetase (ADSS) utilizes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a94ca5005a6d67f05577f1ec1838e1
https://doi.org/10.1021/acs.biochem.5b01386
https://doi.org/10.1021/acs.biochem.5b01386
Autor:
Mrinalini Puranik, Vishakha Karnawat
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 151:679-686
Analogues of intermediates involved in the purine salvage pathway can be exploited as potential drug molecules against enzymes of protozoan parasites. To develop such analogues we need knowledge of the solution structures, predominant tautomer at phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a10145f5f58d333f390bd021e9e69
https://doi.org/10.1016/j.saa.2015.07.013
https://doi.org/10.1016/j.saa.2015.07.013
Publikováno v:
ChemPhysChem. 16:2172-2181
Plasmodium falciparum (Pf) hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a potential therapeutic target. Compared to structurally homologous human enzymes, it has expanded substrate specificity. In this study, 9-deazapurines are used as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1921da776fce918dbf0d8276ea070d
https://doi.org/10.1002/cphc.201500084
https://doi.org/10.1002/cphc.201500084
Publikováno v:
The FASEB Journal. 29
Enzymes of the salvage pathway are essential to understanding the biochemistry of parasitic protozoa. These parasites lack de novo pathway for nucleotide synthesis and depend solely on purines salv...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8595d201f7d5b3951242dd50e641720e
https://doi.org/10.1096/fasebj.29.1_supplement.721.19
https://doi.org/10.1096/fasebj.29.1_supplement.721.19