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Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 983.36 of the human histamine H4 receptor

Autor: Nijmeijer, S, Engelhardt, H, Schultes, S, van de Stolpe, A C, Lusink, V, de Graaf, C, Wijtmans, M, Haaksma, E E J, de Esch, I J P, Stachurski, K, Vischer, H F, Leurs, R

The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H₄ receptor suggests that the 2-amino group of these ligands interacts with glutamic acid residue E182(5.46) in the transmembrane (TM) helix 5 of this receptor. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d40cdd36135c8e24f803a44bc632a80f
https://europepmc.org/articles/PMC3764852/

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A

Autor: Verheij, M. H. P., Chris de Graaf, Kloe, G. E., Saskia Nijmeijer, Vischer, H. F., Smits, R. A., Zuiderveld, O. P., Hulscher, T. M., Silvestri, A., Thompson, A. J., Jacqueline van Muijlwijk-Koezen, Lumnis, S. C. R., Rob Leurs, I.J.P. de Esch

Publikováno v: Verheij, M H P, de Graaf, C, de Kloe, G E, Nijmeijer, S, Vischer, H F, Smits, R A, Zuiderveld, O P, Hulscher, T M, Silvestri, A, Thompson, A J, van Muijlwijk-Koezen, J E, Lumnis, S C R, Leurs, R & de Esch, I J P 2011, ' Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A ', Bioorganic and Medicinal Chemistry Letters, vol. 21, pp. 5460-5464 .
Vrije Universiteit Amsterdam
Bioorganic and Medicinal Chemistry Letters, 21, 5460-5464. Elsevier Limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1084465f473465c1e1f27bae95180b0c
https://research.vu.nl/en/publications/28080edc-56e4-4393-b373-2ea739b5af6a

Virus-encoded G-protein-coupled receptors:constitutively active (dys)regulators of cell function and their potential as drug target

Autor: Vischer, H F, Hulshof, J W, de Esch, I J P, Smit, M J, Leurs, R

Publikováno v: Vischer, H F, Hulshof, J W, de Esch, I J P, Smit, M J & Leurs, R 2006, ' Virus-encoded G-protein-coupled receptors : constitutively active (dys)regulators of cell function and their potential as drug target ', Ernst Schering Foundation Symposium Proceedings, no. 2, pp. 187-209 .

G-protein-coupled receptors encoded by herpesviruses such as EBV, HCMV and KSHV are very interesting illustrations of the (patho)physiological importance of constitutive GPCR activity. These viral proteins are expressed on the cell surface of infecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4612::9a6dd05e80ffc92887dba599ad921eb2
https://hdl.handle.net/1871.1/095289e9-a4fa-467f-8578-19dc2259b175

Discrepancy between molecular structure and ligand selectivity of a testicular follicle-stimulating hormone receptor of the African catfish (Clarias gariepinus)

Autor: Bogerd, J., Blomenröhr, M., Andersson, E., van der Putten, H., Tensen, C.P., Vischer, H F, Granneman, Joke C M, Janssen-Dommerholt, C, Goos, H.J., Schulz, Rüdiger W

Publikováno v: Bogerd, J, Blomenröhr, M, Andersson, E, van der Putten, H, Tensen, C P, Vischer, H F, Granneman, J C M, Janssen-Dommerholt, C, Goos, H J & Schulz, R W 2001, ' Discrepancy between molecular structure and ligand selectivity of a testicular follicle-stimulating hormone receptor of the African catfish (Clarias gariepinus) ', Biology of Reproduction, vol. 64, no. 6, pp. 1633-43 . https://doi.org/10.1095/biolreprod64.6.1633
Biology of Reproduction, 64(6), 1633-43. Society for the Study of Reproduction

A putative FSH receptor (FSH-R) cDNA was cloned from African catfish testis. Alignment of the deduced amino acid sequence with other (putative) glycoprotein hormone receptors and analysis of the African catfish gene indicated that the cloned receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0ffefe410aad7e1a5ecd56951b84716e
https://research.vu.nl/en/publications/253883fd-80d9-4eae-8f34-32d21da626ad