Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation

Autor: Shufen Guo, Yu Wang, Qingling Duan, Wei Gu, Qun Fu, Zhengliang Ma, Jiaping Ruan

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

BackgroundSress early in life has been linked to visceral hyperalgesia and associated functional gastrointestinal disorders. In a mouse model of visceral hyperalgesia, we investigated whether the EphB2 receptor and its EphrinB2 ligand in spinal cord

Externí odkaz: https://doaj.org/article/09f75efdc45044fdbcf11bb0b35f113f

Corrigendum: Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation

Autor: Shufen Guo, Yu Wang, Qingling Duan, Wei Gu, Qun Fu, Zhengliang Ma, Jiaping Ruan

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Externí odkaz: https://doaj.org/article/8adaec361305401bb3e92135a39ba21b

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Corrigendum: Activation of EphrinB2/EphB2 signaling in the spine cord alters glia-neuron interactions in mice with visceral hyperalgesia following maternal separation.

Autor: Guo S; Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Wang Y; Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Duan Q; Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China., Gu W; Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Fu Q; Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Ma Z; Department of Anesthesiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China., Ruan J; Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Sep 27; Vol. 15, pp. 1491784. Date of Electronic Publication: 2024 Sep 27 (Print Publication: 2024).

The Gain-of-Function R222S Variant in Scn11a Contributes to Visceral Hyperalgesia and Intestinal Dysmotility in Scn11aR222S/R222S Mice

Autor: Chenyu Zhao, Jishuo Jin, Haoye Hu, Xi Zhou, Xiaoliu Shi

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundThe SCN11A gene encodes the α-subunit of the Nav1. 9 channel, which is a regulator of primary sensory neuron excitability. Nav1.9 channels play a key role in somatalgia. Humans with the gain-of-function mutation R222S in SCN11A exhibit fam

Externí odkaz: https://doaj.org/article/ad115e12091849c19304d8d8974f8722