Výsledky vyhledávání - "Viruses/immunology"

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

Publikováno v: Journal of immunology (Baltimore, Md., 204(5), 1119-1133. American Association of Immunologists
The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to undergo marked numerical changes with age in humans, our understanding of how MAIT cells are altered during different phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c89e19a9231fbf54a016acadd9d1b6
https://doi.org/10.4049/jimmunol.1900774

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Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany

Autor: Christian Posch, Veronica Aedo-Lopez, Julian Kofler, Julia Maria Ressler, Peter Koelblinger, Matthias Karasek, Christoph Hoeller, Christine Hafner, Helmut Kehrer, Olivier Michielin, Rita Silmbrod, Felix Weihsengruber, Erika Richtig, Lukas Koch, Sofiya Latifyan, Joanna Mangana

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for immunotherapy of cancer, vol. 9, no. 2, pp. e001701

BackgroundTalimogene laherparepvec (T-VEC) is a licensed therapy for use in melanoma patients of stage IIIB-IVM1a with injectable, unresectable metastatic lesions in Europe. Approval was based on the Oncovex Pivotal Trial in Melanoma study, which als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed27d867e0f6ae9e5fa254d7177dae2c
https://mediatum.ub.tum.de/1653382

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Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo

Autor: Daan Augustijn, Karli R. Reiding, C. Erik Hack, Louis J. Bont, Maaike Nederend, Jeanette H. W. Leusen, Manfred Wuhrer, Frank E. J. Coenjaerts, Shamir R. Jacobino, Jan Meeldijk, J. H. Marco Jansen, J. Frederiek Reijneveld

Publikováno v: mAbs, 10(3), 453. Landes Bioscience
mAbs
mAbs, 10(3), 453-462

Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization and mortality in young children. Protective therapy options are limited. Currently, palivizumab, a monoclonal IgG1 antibody, is the only licensed drug for RSV prophylax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3cd91f31232627ce6680f38ab00673
https://doi.org/10.1080/19420862.2018.1433974

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Zebrafish ISG15 Exerts a Strong Antiviral Activity against RNA and DNA Viruses and Regulates the Interferon Response

Autor: L.M. van der Aa, Armel Houel, Christelle Langevin, Aurélie Lunazzi, Abdallah Harmache, Michel Brémont, Valérie Briolat, Pierre Boudinot, Corinne Torhy, Jean-Pierre Levraud

Publikováno v: Journal of Virology 18 (87), 10025-10036. (2013)
Journal of Virology
Journal of Virology 87 (2013) 18
Journal of Virology, 87(18), 10025-10036
Journal of Virology, American Society for Microbiology, 2013, 87 (18), pp.10025-10036. ⟨10.1128/JVI.01294-12⟩
Journal of Virology, 2013, 87 (18), pp.10025-10036. ⟨10.1128/JVI.01294-12⟩

ISG15, a 15-kDa interferon-induced protein that participates in antiviral defenses of mammals, is highly conserved among vertebrates. In fish, as in mammals, viral infection and interferon treatment induce isg15 expression. The two ubiquitin-like dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8093d4ad8d5937c22d4188129df3268
https://doi.org/10.1128/jvi.01294-12

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Pathogen manipulation of B cells: the best defence is a good offence

Autor: Armelle Phalipon, Katharina Nothelfer, Philippe J. Sansonetti

Publikováno v: Nature Reviews Microbiology
Nature Reviews Microbiology, 2015, 13 (3), pp.173-184. ⟨10.1038/nrmicro3415⟩
Nature Reviews Microbiology, Nature Publishing Group, 2015, 13 (3), pp.173-184. ⟨10.1038/nrmicro3415⟩
Nature Reviews Microbiology, 13(3), 173-184. Nature Publishing Group

International audience; B cells have long been regarded as simple antibody production units, but are now becoming known as key players in both adaptive and innate immune responses. However, several bacteria, viruses and parasites have evolved the abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5568652c85a94f5593b9fdb18eca0f23
https://doi.org/10.1038/nrmicro3415

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Análise do processo diferenciado de aspiração do palivizumabe

Autor: Gisleine Aparecida de Castro Arone, Ana Aparecida Sanches Bersusa, Rosemeire Sartori de Albuquerque, Vanessa Peres Leandro, Corintio Mariani Neto

Publikováno v: Acta Paulista de Enfermagem, Vol 27, Iss 1, Pp 69-75 (2014)
Acta Paulista de Enfermagem, Volume: 27, Issue: 1, Pages: 69-75, Published: FEB 2014
Acta Paulista de Enfermagem v.27 n.1 2014
Acta Paulista de Enfermagem
Universidade Federal de São Paulo (UNIFESP)
instacron:USP

OBJECTIVE: Assess the differentiated aspiration process of palivizumab, from planning to administration, and from the patient's profile to obtained savings as a result of the optimization of doses.METHODS: Cross-sectional study carried out by means o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82ffad806bfcab6dceae830c04ff9b1
https://doi.org/10.1590/1982-0194201400014

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Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

Autor: Christelle Langevin, Valérie Briolat, Armel Houel, Elina Aleksejeva, Jean-Pierre Levraud, Pierre Boudinot

Publikováno v: Developmental and Comparative Immunology
Developmental and Comparative Immunology, Elsevier, 2016, 57, pp.48-56. ⟨10.1016/j.dci.2015.12.016⟩
Developmental and Comparative Immunology, 2016, 57, pp.48-56. ⟨10.1016/j.dci.2015.12.016⟩

International audience; The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb84df8a1cba345ba16f607072ea5a
https://hal-pasteur.archives-ouvertes.fr/pasteur-02558296

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Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses

Autor: Balimkiz Senman, E. Ashley Moseman, Michael P Flynn, Philip W. Askenase, Silke Paust, Marian Szczepanik, Bao-Zhong Wang, Amalio Telenti, Harvinder S. Gill, Ulrich H. von Andrian, Richard W. Compans

Publikováno v: Nature immunology
Nature immunology, vol. 11, no. 12, pp. 1127-1135

Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines co

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Advances in respiratory syncytial virus vaccine development

Publikováno v: Current Opinion in Investigational Drugs. 5(2):163-170

Respiratory syncytial virus (RSV) is the most important causative agent of respiratory tract infections. Young children with chronic lung or congenital heart disease are at increased risk for severe disease. Intensive research into a candidate vaccin

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https://research.rug.nl/en/publications/7a7b5100-e0ff-4ef6-b27c-8cf5b8932110

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White Spot Syndrome Virus Envelope Protein VP28 Is Involved in the Systemic Infection of Shrimp

Autor: M.C.W. van Hulten, Marjolein Snippe, Just M. Vlak, Jeroen Witteveldt

Publikováno v: van Hulten, M C W, Witteveldt, J, Snippe, M & Vlak, J M 2001, ' White spot syndrome virus envelope protein VP28 is involved in the systemic infection of shrimp ', Virology, vol. 285, no. 2, pp. 228-33 .
Virology 285 (2001)
Virology, 285, 228-233

White spot syndrome virus (WSSV) is a large DNA virus infecting shrimp and other crustaceans. The virus particles contain at least five major virion proteins, of which three (VP26, VP24, and VP15) are present in the rod-shaped nucleocapsid and two (V

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