Zobrazeno 1 - 10
of 427
pro vyhledávání: '"Virus-like particle (VLP)"'
Autor:
Rong Tang, Ying Zeng, Yu Zhou, Qi Liang, Wei Kang, Zhonghua Yang, Xiaoxiang Zheng, Xia Zang, Hongxing Pan, Jing Jin, Fengcai Zhu
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 498-509 (2024)
ABSTRACTBackground Vaccination remains the cornerstone of defense against COVID-19 globally. This study aims to assess the safety and immunogenicity profile of innovative vaccines LYB001.Research design and methods This was a randomized, double-blind
Externí odkaz:
https://doaj.org/article/37e9274838794de8853f72ec7ac8733e
Autor:
Ian Helstrup Nielsen, Anne Bruun Rovsing, Jacob Hørlück Janns, Emil Aagaard Thomsen, Albert Ruzo, Andreas Bøggild, Frederikke Nedergaard, Charlotte Thornild Møller, Thomas Boesen, Søren Egedal Degn, Jagesh V. Shah, Jacob Giehm Mikkelsen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102318- (2024)
To fully utilize the potential of CRISPR-Cas9-mediated genome editing, time-restricted and targeted delivery is crucial. By modulating the pseudotype of engineered lentivirus-derived nanoparticles (LVNPs), we demonstrate efficient cell-targeted deliv
Externí odkaz:
https://doaj.org/article/5b0da4b8e2504d17b7dca8efcfd345d5
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Porcine circovirus type 4 (PCV4), a recently identified circovirus, is prevalent in numerous provinces in China, as well as in South Korea, Thailand, and Europe. PCV4 virus rescued from an infectious clone showed pathogenicity, suggesting th
Externí odkaz:
https://doaj.org/article/3147ac3b178f4eae80e88edd2fa3dee1
Autor:
Shuo Liu, Li Zhang, Wangjun Fu, Ziteng Liang, Yuanling Yu, Tao Li, Jincheng Tong, Fan Liu, Jianhui Nie, Qiong Lu, Shuaiyao Lu, Weijin Huang, Youchun Wang
Publikováno v:
MedComm, Vol 5, Iss 6, Pp n/a-n/a (2024)
Abstract Spike‐protein‐based pseudotyped viruses were used to evaluate vaccines during the COVID‐19 pandemic. However, they cannot be used to evaluate the envelope (E), membrane (M), and nucleocapsid (N) proteins. The first generation of virus
Externí odkaz:
https://doaj.org/article/c25f891a58b640f9883f7220fd6dd4f6
Publikováno v:
Vaccines, Vol 12, Iss 8, p 927 (2024)
Although many people have been vaccinated against COVID-19, infections with SARS-CoV-2 seem hard to avoid. There is a need to develop more effective vaccines and immunization strategies against emerging variants of infectious diseases. To understand
Externí odkaz:
https://doaj.org/article/4e4dfe0bb64244f3884d9c2f21bcb610
Publikováno v:
Vaccines, Vol 12, Iss 6, p 667 (2024)
Influenza viruses can cause highly infectious respiratory diseases, posing noteworthy epidemic and pandemic threats. Vaccination is the most cost-effective intervention to prevent influenza and its complications. However, reliance on embryonic chicke
Externí odkaz:
https://doaj.org/article/bac53bc2289646ac97e19fd63deca726
Autor:
Raquel Ortiz, Ana Barajas, Anna Pons-Grífols, Benjamin Trinité, Ferran Tarrés-Freixas, Carla Rovirosa, Víctor Urrea, Antonio Barreiro, Anna Gonzalez-Tendero, Maria Rovira-Rigau, Maria Cardona, Laura Ferrer, Bonaventura Clotet, Jorge Carrillo, Carmen Aguilar-Gurrieri, Julià Blanco
Publikováno v:
Viruses, Vol 16, Iss 6, p 987 (2024)
The envelope glycoprotein (Env) of retroviruses, such as the Feline leukemia virus (FeLV), is the main target of neutralizing humoral response, and therefore, a promising vaccine candidate, despite its reported poor immunogenicity. The incorporation
Externí odkaz:
https://doaj.org/article/28f6dcb59e8c49f0b75c64e52e01d415
Autor:
Muhammad Shuaib, Sabir Adroub, Tobias Mourier, Sara Mfarrej, Huoming Zhang, Luke Esau, Afrah Alsomali, Fadwa S Alofi, Adeel Nazir Ahmad, Abbas Shamsan, Asim Khogeer, Anwar M. Hashem, Naif A. M. Almontashiri, Sharif Hala, Arnab Pain
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background The excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of COVID-19. Previous work found that two adjacent co-occurring mutations R203K and G204R (KR) on the
Externí odkaz:
https://doaj.org/article/a4d0f2c9f1e8463a8e98ac60176315bd
Autor:
Xiaolan Yong, Jun Liu, Ying Zeng, Jing Nie, Xuelian Cui, Tao Wang, Yilin Wang, Yiyong Chen, Wei Kang, Zhonghua Yang, Yan Liu
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)
LYB001 is an innovative recombinant SARS-CoV-2 vaccine that displays a repetitive array of the spike glycoprotein’s receptor-binding domain (RBD) on a virus-like particle (VLP) vector to boost the immune system, produced using Covalink plug-and-dis
Externí odkaz:
https://doaj.org/article/84a2e0b5d3f744cc9946a4533fed70ed
Autor:
Megolhubino Terhüja, Manjunath Siddappa, Pramila Lamichhane, Chetan D. Meshram, Timothy A. Snider, Jerry W. Ritchey, Antonius G. P. Oomens
Publikováno v:
Viruses, Vol 16, Iss 6, p 843 (2024)
Respiratory syncytial virus (RSV) is a major cause of severe respiratory tract disease worldwide, and a pediatric vaccine is not available. We generated a filamentous RSV-based virus-like particle (VLP) that presents the central conserved region of t
Externí odkaz:
https://doaj.org/article/b43bad425d5e43d9a8b2df644af6ede3