Process design and optimization towards digital twins for HIV-gag VLP production in HEK293 cells, including purification

Autor: Heribert Helgers, Alina Hengelbrock, Axel Schmidt, Jamila Rosengarten, Jörn Stitz, Jochen Strube

Publikováno v: Processes; Volume 10; Issue 2; Pages: 419

Despite great efforts to develop a vaccine against human immunodeficiency virus (HIV), which causes AIDS if untreated, no approved HIV vaccine is available to date. A promising class of vaccines are virus-like particles (VLPs), which were shown to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb25adcac4a2680945db53f0e02b7259
https://dokumente.ub.tu-clausthal.de/servlets/MCRFileNodeServlet/clausthal_derivate_00001653/processes-10-00419.pdf

Digital Twin for HIV-Gag VLP Production in HEK293 Cells

Autor: Alina Hengelbrock, Heribert Helgers, Axel Schmidt, Florian Lukas Vetter, Alex Juckers, Jamila Franca Rosengarten, Jörn Stitz, Jochen Strube

Publikováno v: Processes; Volume 10; Issue 5; Pages: 866

The development and adoption of digital twins (DT) for Quality-by-Design (QbD)-based processes with flexible operating points within a proven acceptable range (PAR) and automation through Advanced Process Control (APC) with Process Analytical Technol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e687dc5c645564c6e02fc0b6492bc815
https://doi.org/10.3390/pr10050866

Beneficial effect of selective virus elimination on the performance of Vitis vinifera cv. Chardonnay

Autor: Komar, V., Emmanuelle VIGNE, Demangeat, G., Fuchs, M.

Publikováno v: American Journal of Enology and Viticulture
American Journal of Enology and Viticulture, American Society for Enology and Viticulture, 2007, 58 (2), pp.202-210
Scopus-Elsevier

International audience; The effect of selective virus elimination on vigor, yield, and fruit quality of Vitis vinifera cv. Chardonnay was evaluated over six years in a replicate field trial. Test material was propagated from three clones infected by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a50a1b4c696aa0b947453489773d4e49
https://hal.inrae.fr/hal-02656657

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