Zobrazeno 1 - 10 of 98 pro vyhledávání: '"Virus Effects on Host Gene Expression"'
1
Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus
Autor: Boris Bogdanow, Markus Landthaler, Q.V. Phan, Lueder Wiebusch, Emanuel Wyler, Christian Hagemeier, F. Liu
Publikováno v: PLoS Pathogens, Vol 18, Iss 1, p e1010193 (2022)
PLoS Pathogens
The chimpanzee cytomegalovirus (CCMV) is the closest relative of human CMV (HCMV). Because of the high conservation between these two species and the ability of human cells to fully support CCMV replication, CCMV holds great potential as a model syst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef97cc76854250bbd7b6a69159f220a0
http://edoc.mdc-berlin.de/21236/1/21236oa.pdf
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2
The Mimivirus L375 Nudix enzyme hydrolyzes the 5’ mRNA cap
Autor: Grace Kago, Susan Parrish
Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0245820 (2021)
The giant Mimivirus is a member of the nucleocytoplasmic large DNA viruses (NCLDV), a group of diverse viruses that contain double-stranded DNA (dsDNA) genomes that replicate primarily in eukaryotic hosts. Two members of the NCLDV, Vaccinia Virus (VA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eeb1f0b212607fd5603d51af17d5618
http://europepmc.org/articles/PMC8478210
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3
Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity
Autor: Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v: PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469a676bb0e1666248dc84b8e1cb1c58
http://europepmc.org/articles/PMC8423302
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4
RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters
Autor: Britt A. Glaunsinger, Ileana M. Cristea, Ella Hartenian, Sarah Gilbertson, Joel D. Federspiel
Publikováno v: PLoS pathogens, vol 16, iss 2
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 2, p e1008269 (2020)
PLoS pathogens, 16(2):e1008269
PLOS Pathogens
PLoS Pathogens, vol 16, iss 2
In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including K
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5187a4d52f54ad85d60dcc46f334631e
https://escholarship.org/uc/item/234532tp
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5
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis
Autor: Stephen Smith, Giovanni Bussotti, Cinzia G. Scarpini, Nicholas Coleman, Peter Fraser, Stefan Schoenfelder, Jack M. Monahan, Anton J. Enright, Ian J. Groves, Csilla Várnai, Emma L. A. Drane, Marco Michalski
Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 8, p e1009875 (2021)
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered epigenetic changes at the int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54580ade474293234e2a2d3bbb1fa7ba
https://www.repository.cam.ac.uk/handle/1810/328538
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6
Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?
Autor: Sage Z. Davis, Todd Lenz, Karine G. Le Roch, Thomas Hollin
Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 2, p e1009207 (2021)
PLoS pathogens, vol 17, iss 2
The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrang
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef941bbb9971c04eb0b4ee01710551bd
http://europepmc.org/articles/PMC7861443
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7
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
Autor: Hui Feng, Daisuke Yamane, Stanley M. Lemon, Jian-Fang Gui, Yi-Bing Zhang
Publikováno v: PLoS Pathogens, Vol 17, Iss 1, p e1009220 (2021)
PLoS Pathogens
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897efe5c34c91355edbe7ee9b4a6d927
https://doaj.org/article/c99de97c15904b48a8e94d01b7b7f3b4
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8
Viral infection of human neurons triggers strain-specific differences in host neuronal and viral transcriptomes
Autor: Colleen A. Mangold, Daniel W. Renner, Molly M. Rathbun, Chad V. Kuny, Moriah L. Szpara
Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 3, p e1009441 (2021)
Infection with herpes simplex virus 1 (HSV-1) occurs in over half the global population, causing recurrent orofacial and/or genital lesions. Individual strains of HSV-1 demonstrate differences in neurovirulence in vivo, suggesting that viral genetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485674835792ca78b4aebf3f81107df2
https://pubmed.ncbi.nlm.nih.gov/33750985
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9
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1
Autor: Alsamman M. Alsamman, Hatem Zayed
Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243270 (2020)
The SARS-CoV-2 (COVID-19) pandemic is a global crisis that threatens our way of life. As of November 18, 2020, SARS-CoV-2 has claimed more than 1,342,709 lives, with a global mortality rate of ~2.4% and a recovery rate of ~69.6%. Understanding the in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8557264c55e2037495b5d5db42a6b48
http://europepmc.org/articles/PMC7728291
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10
The impact of genetic adaptation on chimpanzee subspecies differentiation
Autor: Sergi Castellano, Joshua M. Schmidt, Tomas Marques-Bonet, Marc de Manuel, Aida M. Andrés
Publikováno v: PLoS Genetics
Recercat. Dipósit de la Recerca de Catalunya
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PLOS Genetics
PLoS Genetics, Vol 15, Iss 11, p e1008485 (2019)
Chimpanzees, humans’ closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their habitats, which shrink in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89bb743756e97f8dfff441de3bd366bf
https://pubmed.ncbi.nlm.nih.gov/31765391
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