Screening of active constituents in traditional Chinese medicines as potential Salmonella Typhimurium virulence inhibitors targeting Salmonella pathogenicity island III

Autor: Mengdi Cui, Ou Tao, Yuanyuan Wang, Yulei Yang, Sufen Miao, Junling Hou, Xiaopeng Deng, Meng Shen, Shanshan Jia, Mei Zhang

Publikováno v: Journal of Traditional Chinese Medical Sciences, Vol 10, Iss 4, Pp 493-501 (2023)

Objective: To screen active constituents of traditional Chinese medicines (TCMs) as potential virulence inhibitors of Salmonella pathogenicity island III (SPI-3). Methods: The potential binding of TCM constituents to the MgtC protein of SPI-3 was cla

Externí odkaz: https://doaj.org/article/614cb52ee0a24be6a24b24e00f774e57

Naringenin Inhibition of the Pseudomonas aeruginosa Quorum Sensing Response Is Based on Its Time-Dependent Competition With N-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding

Autor: Sara Hernando-Amado, Manuel Alcalde-Rico, Teresa Gil-Gil, José R. Valverde, José L. Martínez

Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)

Bacterial quorum sensing (QS) is a cell-to-cell communication system that governs the expression of a large set of genes involved in bacterial–host interactions, including the production of virulence factors. Conversely, the hosts can produce anti-

Externí odkaz: https://doaj.org/article/1cfba791ead94908b08241962d37c730

Identification of Benzyloxy Carbonimidoyl Dicyanide Derivatives as Novel Type III Secretion System Inhibitors via High-Throughput Screening

Autor: Yi-Nan Ma, Liang Chen, Nai-Guo Si, Wen-Jun Jiang, Zhi-Gang Zhou, Jun-Li Liu, Li-Qun Zhang

Publikováno v: Frontiers in Plant Science, Vol 10 (2019)

The type III secretion system (T3SS) in many Gram-negative bacterial pathogens is regarded as the most critical virulence determinant and an attractive target for novel anti-virulence drugs. In this study, we constructed a T3SS secretion reporter con

Externí odkaz: https://doaj.org/article/1dc17ad7887241338cbfbb84ddc35d3b

Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex

Autor: Cherrak, Y., Filella-Merce, I., Schmidt, V., Byrne, D., Sgoluppi, V., Chaiaheloudjou, R., Betzi, S., Morelli, X., Nilges, M., Pellarin, R., Durand, E.

Publikováno v: mBio
mBio, 2021, 12 (4), ⟨10.1128/mBio.01348-21⟩
mBio, 2021, 12 (4), ⟨10.1128/mbio.01348-21⟩
mBio, 2021, 12 (4), pp.e0134821. ⟨10.1128/mBio.01348-21⟩
mBio, American Society for Microbiology, 2021, 12 (4), ⟨10.1128/mbio.01348-21⟩
mBio, Vol 12, Iss 4 (2021)

International audience; Human health is threatened by bacterial infections that are increasingly resistant to multiple drugs. A recently emerged strategy consists of disarming pathogenic bacteria by targeting and blocking their virulence factors. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::69e621a61ecafcc9623245b2e10e8518
https://hal-amu.archives-ouvertes.fr/hal-03366988

Naringenin Inhibition of the

Autor: Sara, Hernando-Amado, Manuel, Alcalde-Rico, Teresa, Gil-Gil, José R, Valverde, José L, Martínez

Publikováno v: Frontiers in Molecular Biosciences

Bacterial quorum sensing (QS) is a cell-to-cell communication system that governs the expression of a large set of genes involved in bacterial–host interactions, including the production of virulence factors. Conversely, the hosts can produce anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76609721a01b6f757feb7c437ffae3d6
https://pubmed.ncbi.nlm.nih.gov/32181260