Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Virpi Talman"'
Autor:
Mikael Jumppanen, Sini M. Kinnunen, Matej Zore, Mika J. Välimäki, Virpi Talman, Gustav Boije af Gennäs, Heikki J. Ruskoaho, Jari Yli-Kauhaluoma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently no cure to prevent and reverse cardiac remodeling
Externí odkaz:
https://doaj.org/article/2029b729860d4650ad7fb8a5f2680938
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAfter birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various ce
Externí odkaz:
https://doaj.org/article/520f1e19c9654d1d87cde56cc0f41872
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100020- (2022)
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs)
Externí odkaz:
https://doaj.org/article/fc2a6429601c4ef69f9f2a67e6504b33
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Externí odkaz:
https://doaj.org/article/3d32b0334d36473a86f18126267d3d4d
Autor:
Maria H. Jäntti, Virpi Talman, Kati Räsänen, Ilari Tarvainen, Hannu Koistinen, Raimo K. Tuominen
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 817-828 (2018)
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5‐year survival rate, development of resistance to standard androgen‐deprivation therapy is a significant clinical problem. Therefore, novel therapeutic s
Externí odkaz:
https://doaj.org/article/04c1350fde84491bb7286f40dc0a2c00
Autor:
Virpi Talman, Jaakko Teppo, Päivi Pöhö, Parisa Movahedi, Anu Vaikkinen, S. Tuuli Karhu, Kajetan Trošt, Tommi Suvitaival, Jukka Heikkonen, Tapio Pahikkala, Tapio Kotiaho, Risto Kostiainen, Markku Varjosalo, Heikki Ruskoaho
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background The molecular mechanisms mediating postnatal loss of cardiac regeneration in mammals are not fully understood. We aimed to provide an integrated resource of mRNA, protein, and metabolite changes in the neonatal heart for identification of
Externí odkaz:
https://doaj.org/article/9482c6aaa55e4ff6836035f853b4f626
Autor:
Virpi Talman, Riikka Kivelä
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
The heart is a complex organ consisting of various cell types, each of which plays an important role in both physiological and pathophysiological conditions. The cells communicate with each other through direct cell-cell interactions and paracrine si
Externí odkaz:
https://doaj.org/article/d75462e6ce9c4afbaa73df1f8aad90b0
Autor:
Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)
Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro
Externí odkaz:
https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1
Publikováno v:
PLoS ONE, Vol 6, Iss 6 (2011)
Externí odkaz:
https://doaj.org/article/e41a481fc557426d9181fc2460a2043a