Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin

Autor: Pratikhya Pratikhya, Chun-Ling Jung, Alan J. Waring, Hai Luong, Piotr Ruchala, Martin L. Phillips, Amy L. Cole, Shantanu Sharma, Ewa D. Micewicz, Alexander M. Cole

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 12, p e14360 (2010)

Background: Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1731c3b37448d883ebce544d88ed9672
https://resolver.caltech.edu/CaltechAUTHORS:20110125-105140147

Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds

Autor: Laura I. Levi, Malia J. McPherson, Jamie J. Arnold, Stéphanie Beaucourt, Bruno Baron, Marco Vignuzzi, Nina F. Gnädig

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2010, 6 (10), pp.e1001163. ⟨10.1371/journal.ppat.1001163⟩
PLoS Pathogens, Public Library of Science, 2010, 6 (10), pp.e1001163. ⟨10.1371/journal.ppat.1001163⟩
PLoS Pathogens, Vol 6, Iss 10, p e1001163 (2010)

In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize that amiloride has a previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c81d1d931e56d1bfdfa6f17a6484cf5

In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions

Autor: Aihua Zheng, Mahadevaiah Umashankar, Margaret Kielian

Publikováno v: PLoS Pathogens, Vol 6, Iss 10, p e1001157 (2010)
PLoS Pathogens

Flaviviruses bud into the endoplasmic reticulum and are transported through the secretory pathway, where the mildly acidic environment triggers particle rearrangement and allows furin processing of the prM protein to pr and M. The peripheral pr pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80407e3124697d2cf11b4ba8ff34f66e
http://europepmc.org/articles/PMC2958806?pdf=render

Quasispecies theory and the behavior of RNA viruses

Autor: Raul Andino, Adam S. Lauring

Publikováno v: PLoS Pathogens, Vol 6, Iss 7, p e1001005 (2010)
PLoS Pathogens

A large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity. This diversity allows a viral popu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f36705bef597937bd50f827471bb24
http://europepmc.org/articles/PMC2908548?pdf=render

Cell Cycle Progression or Translation Control Is Not Essential for Vesicular Stomatitis Virus Oncolysis of Hepatocellular Carcinoma

Autor: Wolfgang E. Thasler, Roland M. Schmid, Oliver Ebert, Sabrina Marozin, Alexandra Junger, Nobuyuki Kato, Günter Schneider, Enrico N. De Toni, Jennifer Altomonte, Antonia Rizzani

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e10988 (2010)

The intrinsic oncolytic specificity of vesicular stomatitis virus (VSV) is currently being exploited to develop alternative therapeutic strategies for hepatocellular carcinoma (HCC). Identifying key regulators in diverse transduction pathways that de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f2dfbdc4d4a8ee4d164c3c0aade99c
http://europepmc.org/articles/PMC2881869