Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Virion secretion"'
Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection
Autor:
Renyun Tian, Di Yang, Biaoming Xu, Rilin Deng, Binbin Xue, Luoling Wang, Huiyi Li, Qian Liu, Xiaohong Wang, Songqing Tang, Mengyu Wan, Hua Pei, Haizhen Zhu
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT The absence of a hepatitis B virus (HBV) infection system has constrained the study of the viral life cycle and the development of antiviral drugs. We previously established a hepatocellular carcinoma cell line, HLCZ01, that can support the
Externí odkaz:
https://doaj.org/article/a4f46cb1f9c74f99a063dbb8b71dd418
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-16 (2022)
Abstract Background Hepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism of virion secretion remains to be investigated. Previously, we found that nuclear export o
Externí odkaz:
https://doaj.org/article/2d36e4a7b21d4504afc6b382465902c8
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Abstract Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We noted that this mutan
Externí odkaz:
https://doaj.org/article/70350f114ccb4ddca3c6ea7e42a31ef1
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 672 (2023)
We investigate the role of Tachyplesin (Tpl), a marine antimicrobial cell-penetrating peptide, as an anti-HBV agent. Our findings, using confocal microscopy and flow cytometry, demonstrate the internalization of FITC-Tpl in both Huh7 and HepG2 cell l
Externí odkaz:
https://doaj.org/article/3664b3a03cf94556b562193ba1172bf7
Autor:
Jaewon Yang, Alexander König, Soonju Park, Eunji Jo, Pil Soo Sung, Seung Kew Yoon, Eva Zusinaite, Denis Kainov, David Shum, Marc Peter Windisch
Publikováno v:
JHEP Reports, Vol 3, Iss 4, Pp 100296- (2021)
Background & Aims: Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to
Externí odkaz:
https://doaj.org/article/1e0390c1447c43c2833a8a97f1de481f
Akademický článek
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Publikováno v:
Viruses, Vol 14, Iss 2, p 291 (2022)
The hepatitis C virus (HCV) co-opts numerous cellular elements, including proteins, lipids, and microRNAs, to complete its viral life cycle. The cellular RNA-binding protein, poly(rC)-binding protein 1 (PCBP1), was previously reported to bind to the
Externí odkaz:
https://doaj.org/article/0a4adc1e43b64119b90db68a82df2f89
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Cells, Vol 10, Iss 1, p 43 (2020)
In natural infection, hepatitis B virus (HBV) core protein (HBc) accumulates frequent mutations. The most frequent HBc variant in chronic hepatitis B patients is mutant 97L, changing from an isoleucine or phenylalanine to a leucine (L) at HBc amino a
Externí odkaz:
https://doaj.org/article/8f52cc5eed3844399fdcd86b945ca5f9
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Journal of Biomedical Science
Journal of Biomedical Science
Background The virion secretion mechanism of human hepatitis B virus (HBV) remains to be investigated. In our current study, we characterized a reverse transcriptase mutant, which changed from the YMDD motif to YMHA. We noted that this mutant YMHA se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1efd39c0ad582ca9fe1e06e7013542
https://doaj.org/article/70350f114ccb4ddca3c6ea7e42a31ef1
https://doaj.org/article/70350f114ccb4ddca3c6ea7e42a31ef1