Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Virginijus, Siksnys"'
Autor:
Pierre Aldag, Marius Rutkauskas, Julene Madariaga-Marcos, Inga Songailiene, Tomas Sinkunas, Felix Kemmerich, Dominik Kauert, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract CRISPR-Cas effector complexes enable the defense against foreign nucleic acids and have recently been exploited as molecular tools for precise genome editing at a target locus. To bind and cleave their target, the CRISPR-Cas effectors have t
Externí odkaz:
https://doaj.org/article/e871251abb314dc899785b43baed2dc2
Autor:
Marius Rutkauskas, Inga Songailiene, Patrick Irmisch, Felix E. Kemmerich, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Based on thorough single-molecule analysis of off-target binding by the CRISPR-Cas surveillance complex Cascade, a mechanism-based model is presented that quantitatively describes the recognition dynamics of mutated targets by this protein.
Externí odkaz:
https://doaj.org/article/c899fa03b0a74176bb9813625f974959
Autor:
Greta Bigelyte, Joshua K. Young, Tautvydas Karvelis, Karolina Budre, Rimante Zedaveinyte, Vesna Djukanovic, Elizabeth Van Ginkel, Sushmitha Paulraj, Stephen Gasior, Spencer Jones, Lanie Feigenbutz, Grace St. Clair, Pierluigi Barone, Jennifer Bohn, Ananta Acharya, Gina Zastrow-Hayes, Selgar Henkel-Heinecke, Arunas Silanskas, Ralf Seidel, Virginijus Siksnys
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Miniature Cas12f editing systems are well suited for in vivo editing applications. Here the authors characterize the intrinsic activity of SpCas12f1 in plant and animal cells.
Externí odkaz:
https://doaj.org/article/688a63ea2c9f45e084a40d762048f444
Autor:
Giedrius Gasiunas, Joshua K. Young, Tautvydas Karvelis, Darius Kazlauskas, Tomas Urbaitis, Monika Jasnauskaite, Mantvyda M. Grusyte, Sushmitha Paulraj, Po-Hao Wang, Zhenglin Hou, Shane K. Dooley, Mark Cigan, Clara Alarcon, N. Doane Chilcoat, Greta Bigelyte, Jennifer L. Curcuru, Megumu Mabuchi, Zhiyi Sun, Ryan T. Fuchs, Ezra Schildkraut, Peter R. Weigele, William E. Jack, G. Brett Robb, Česlovas Venclovas, Virginijus Siksnys
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
A few bacterial Cas9 nucleases have been repurposed as genome editing tools. Here, the authors use bioinformatic and biochemical analyses to characterize 79 Cas9 proteins, revealing substantial functional diversity and thus expanding the available to
Externí odkaz:
https://doaj.org/article/eff8b92a7b8248269794dd870fd5600c
Autor:
Giedrius Sasnauskas, Giedre Tamulaitiene, Gytis Druteika, Arturo Carabias, Arunas Silanskas, Darius Kazlauskas, Česlovas Venclovas, Guillermo Montoya, Tautvydas Karvelis, Virginijus Siksnys
Publikováno v:
Nature. 616:384-389
Autor:
Jeremy Garb, Anna Lopatina, Aude Bernheim, Mindaugas Zaremba, Virginijus Siksnys, Sarah Melamed, Azita Leavitt, Adi Millman, Gil Amitai, Rotem Sorek
Publikováno v:
Nature Microbiology. 7:1849-1856
Autor:
Tautvydas Karvelis, Virginijus Siksnys
Publikováno v:
Crispr. :53-69
Autor:
Inga Songailiene, Marius Rutkauskas, Tomas Sinkunas, Elena Manakova, Sabine Wittig, Carla Schmidt, Virginijus Siksnys, Ralf Seidel
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3157-3166.e4 (2019)
Summary: The multi-subunit type I CRISPR-Cas surveillance complex Cascade uses its crRNA to recognize dsDNA targets. Recognition involves DNA unwinding and base-pairing between the crRNA spacer region and a complementary DNA strand, resulting in form
Externí odkaz:
https://doaj.org/article/a545ce10365146db92a8077000d6b635
Autor:
Irmantas Mogila, Migle Kazlauskiene, Skaiste Valinskyte, Giedre Tamulaitiene, Gintautas Tamulaitis, Virginijus Siksnys
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2753-2765.e4 (2019)
Summary: The type III-A Csm complex of Streptococcus thermophilus (StCsm) provides immunity against invading nucleic acids through the coordinated action of three catalytic domains: RNase (Csm3), ssDNase (Cas10-HD), and cyclic oligoadenylates synthas
Externí odkaz:
https://doaj.org/article/47afc86efc0440f09d5bd90817981f46
Autor:
Dominik J. Kauert, Julene Madariaga-Marcos, Marius Rutkauskas, Alexander Wulfken, Inga Songailiene, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel
The discovery1,2and the pioneering applications3of CRISPR-Cas effector complexes have provided powerful gene-editing tools. The effector complexes are guided to the targeted genomic locus by the complementarity of their CRISPR RNA (crRNA)4,5. Recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4268094fd7bb461ed9a926cdc5c570ba
https://doi.org/10.1101/2023.03.17.533087
https://doi.org/10.1101/2023.03.17.533087