Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Virginija Jovaisaite"'
Autor:
Xusheng Wang, Ashutosh K. Pandey, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to
Externí odkaz:
https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b
Autor:
Norman Moullan, Laurent Mouchiroud, Xu Wang, Dongryeol Ryu, Evan G. Williams, Adrienne Mottis, Virginija Jovaisaite, Michael V. Frochaux, Pedro M. Quiros, Bart Deplancke, Riekelt H. Houtkooper, Johan Auwerx
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1681-1691 (2015)
In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show he
Externí odkaz:
https://doaj.org/article/0dcb4c23bfc94665a9e7844015682049
Autor:
Carsten Merkwirth, Jenni Durieux, Kristan K. Steffen, Sarah U. Tronnes, Johan Auwerx, Olli Matilainen, Evan G. Williams, Laurent Mouchiroud, Sabine D. Jordan, Suzanne Wolff, Virginia Murillo, Reuben J. Shaw, Andrew Dillin, Pedro M. Quirós, Virginija Jovaisaite
Publikováno v:
Cell, vol 165, iss 5
Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c26dd40985123aa7a24bf87ba43e34
https://doi.org/10.1016/j.cell.2016.04.012
https://doi.org/10.1016/j.cell.2016.04.012
Autor:
Jinsong Huang, Artem Tishkov, Virginija Jovaisaite, Katherine S. Pollard, Robert W. Williams, Ashutosh K. Pandey, John A. Capra, Lu Lu, Megan K. Mulligan, Johan Auwerx, Zugen Chen, William L. Taylor, Junmin Peng, Khyobeni Mozhui, Lisa Bastarache, L. Darryl Quarles, Daniel C. Ciobanu, Z. Li, Evan G. Williams, Alexander O. Reznik, Joshua C. Denny, Xinnan Niu, Zhousheng Xiao, Stanley F. Nelson, Xusheng Wang, Igor B. Zhulin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ∼5 million sequence variants, and we compare o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e441e39e3468521968728a2ee56848fe
https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b
https://doaj.org/article/cfc59303336541d2b8ee796f1a6ebb5b
Autor:
Johan Auwerx, Virginija Jovaisaite
Publikováno v:
Current Opinion in Cell Biology. 33:74-81
Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fee0bad613b71f76e00a5d4e95916ce
https://doi.org/10.1016/j.ceb.2014.12.003
https://doi.org/10.1016/j.ceb.2014.12.003
Publikováno v:
Journal of Experimental Biology
The ability to respond to various intracellular and/or extracellular stresses allows the organism to adapt to changing environmental conditions and drives evolution. It is now well accepted that a progressive decline of the efficiency of stress respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b284892b90b20968adac2ec3e2b4666
https://doi.org/10.1242/jeb.090738
https://doi.org/10.1242/jeb.090738
Autor:
Shreya Narasimhan, Johan Auwerx, Vincenzo Sorrentino, Gopalan Hariharan Krishnamani, Thomas Lehnert, Virginija Jovaisaite, Martin A. M. Gijs, Alexis Marette, Laurent Mouchiroud, Matteo Cornaglia
Publikováno v:
Biomedical Engineering / Biomedizinische Technik. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e46e6eea9948c3f4204dbf826b0c4c
https://doi.org/10.1515/bmt-2016-5002
https://doi.org/10.1515/bmt-2016-5002
Autor:
Johan Auwerx, Shreya Narasimhan, Matteo Cornaglia, Laurent Mouchiroud, Martin A. M. Gijs, Thomas Lehnert, Alexis Marette, Virginija Jovaisaite
Publikováno v:
Scientific Reports
Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population’s statistics, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0decbc4a36aa02ca42af4897ad0537
https://pubmed.ncbi.nlm.nih.gov/25950235
https://pubmed.ncbi.nlm.nih.gov/25950235
Autor:
Johan Auwerx, Pénélope Andreux, Virginija Jovaisaite, Laurent Mouchiroud, Xu Wang, Norman Moullan, Riekelt H. Houtkooper, Adrienne Mottis, Sabrina Bichet
Publikováno v:
Scientific reports, 4. Nature Publishing Group
Scientific Reports
Scientific Reports
Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576c5bee147cb35f1450095e1d7baca4
https://doi.org/10.1038/srep05285
https://doi.org/10.1038/srep05285
Autor:
Fahd Azzabi, Virginija Jovaisaite, Andreas Boss, Josiane Njiwa, Markus Rudin, Tullio Sulser, Daniel Eberli
Publikováno v:
Journal of Urology. 187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c99fcdcb009a1ed653a7712d52f7da95
https://doi.org/10.1016/j.juro.2012.02.257
https://doi.org/10.1016/j.juro.2012.02.257